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Biomedical subjects

M Scaramelli

Publications and source records attributed to M Scaramelli.

14 recordsLinked to original sources
PubMed1990

[Topical therapy of acute skeletal muscle diseases. Results of a comparative study on piroxicam cream 1% versus diclofenac emulgel 1%].

An open comparative study on 75 patients with the aim to compare efficacy and safety of two non steroidal antiinflammatory drugs for topic use, piroxicam 1% cream (38 patients) and diclofenac 1% emulgel (37 patients) in the acute musculoskeletal disorders (tendinitis, distortion, muscular disorders etc.) has been carried out. Piroxicam has been administered at the dose of 0.5-1 g cream and diclofenac at the dose of 4 g emulgel, both 4 times a day for a period of 14 days. At baseline, 3rd, 7th and 14th days were evaluated: pain on movement, on pressure, function restriction, and the global evolution of symptomatology; at the end of the treatment the patient gave an evaluation on the physical characteristics of the two drugs, and the physician and the patients gave also global evaluation of efficacy and safety. The statistical analysis of the quantitative data (ANOVA and Student's t-tests) and qualitative data (Wilcoxon's test, chi 2 - and Fisher-tests) showed a significative reduction of pain on movement and of function's capacity at 3rd day, of pain on pressure and of function restriction on 7th day with both drugs with a superiority of piroxicam for some of the above mentioned parameters (7th and 14th days). Also the evaluation of the physical characteristics and the global evaluation of efficacy were more favourable for piroxicam. No adverse systemic or local reactions are reported for both drugs.

Administration, Topical↗
PubMed1984

Thiopronine-induced pemphigus vulgaris in rheumatoid arthritis.

Thiopronine, a D-penicillamine-like agent, is being prescribed increasingly for RA. Among side effects, only benign skin reactions have been mentioned to date. A single case of pemphigus erythematosus induced by this drug was recently reported. We describe here 3 other patients who developed pemphigus vulgaris during long-term thiopronine therapy and who improved after the drug was stopped.

Aged↗
PubMed1975

[Pyrasanone in the treatment of rheumatism].

The results of a set of experiments conducted on a new non-steroid antirheumatic preparation--pyrasanone (Carudol)--are presented and its indications in the general management of the disease are noted. The pharmacokinetics and therapeutic efficacy of the new drug are described. Statistical analysis showed it to be more effective than hexahydropyrazine, diphenylbutazone, indomethacin and oxyphenbutazone. A basic therapeutic approach is suggested in accordance with the pharmacodynamic aspects of the drug and the results observed in a clinical trial on 719 subjects. Pyrasanone has low toxicity and is well tolerated. Due caution in the administration of antirheumatic drugs should nevertheless be maintained during its use.

Adult↗
PubMed1975

[Osteopecilia].

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Adult↗