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Biomedical subjects

M Schrey

Publications and source records attributed to M Schrey.

6 recordsLinked to original sources
PubMed2001

Underediting of glutamate receptor GluR-B mRNA in malignant gliomas.

In mammals, RNA editing by site-selective adenosine deamination regulates key functional properties of neurotransmitter receptors in the central nervous system. Glutamate receptor subunit B is nearly 100% edited at one position (the Q/R-site), which is essential for normal receptor function. Its significance is apparent from mouse models in which a slightly reduced rate of Q/R-site editing is associated with early onset epilepsy and premature death. Here we report that in tissues from malignant human brain tumors, this editing position of glutamate receptor subunit B is substantially underedited compared with control tissues. We also observe alterations in editing and alternative splicing of serotonin receptor 5-HT(2C) transcripts. These changes correlate with a decrease in enzymatic activity of the editing enzyme adenosine deaminase acting on RNA (ADAR) 2, as deduced from analysis of ADAR2 self-editing. Our results suggest a role for RNA editing in tumor progression and may provide a molecular model explaining the occurrence of epileptic seizures in association with malignant gliomas.

Adenosine Deaminase↗
PubMed1994

A parents' perspective: our needs and our message.

This article, written by parents, describes their fears and frustrations as the child they love is taken from the joyful family life that had been expected, to the terror of facing the possibility of death in a critical care situation. The parents want to help the medical team in healing their child, yet find themselves in a totally foreign environment in which they are often ineffective. By sharing the feelings experienced during their child's initial diagnosis and treatment, the authors hope that health care professionals will understand better the emotions parents are feeling and that parents can be helped to overcome their fears in order to better assume their role as part of the critical care treatment process.

Adaptation, Psychological↗
PubMed1978

[Exfoliative cytology during topical treatment of oral leukoplakia with vitamin A acid].

Vitamin A acid (VAS) has proved itself an effective local therapeutic agent for intra-oral leucoplakia. Clinical remission characterized by a decrease in horny lumps and the eosinophilic index and an increase in intermediary cells was achieved in 32 out of 50 cases. In the course of maintenance therapy development towards an exfoliocytologically healthy mucosa proceeds via increasing parakeratosis. VAS therapy is essentially thought of as symptomatic therapy.

Administration, Topical↗