Biomedical subjects

M Schwarz-Eywill

Publications and source records attributed to M Schwarz-Eywill.

21 records · Page 2Linked to original sources

PubMed1992

Evaluation of serum ferritin as a marker for adult Still's disease activity.

Extremely high serum ferritin values (greater than 10,000 micrograms/l) were detected in two patients with adult Still's disease. The ferritin concentrations decreased to normal after adequate treatment. During a one year follow up ferritin concentration was helpful in monitoring disease activity and guiding decisions about treatment. Raised concentrations of soluble interleukin 2 receptors (sCD25) were also found. Detection of ferritin values above 3000 micrograms/l should lead to the consideration of Still's disease when there is an acute febrile illness without evidence for bacterial or viral infections, serum ferritin being suitable for monitoring treatment.

Adult↗

PubMed1992

Low-dose methotrexate treatment in noninfectious uveitis resistant to corticosteroids.

A total of 14 patients (10 women and 4 men) ranging in age from 18 to 56 years who presented with active chronic noninfectious uveitis were treated with low-dose methotrexate (MTX). All patients had failed to respond to previous systemic corticosteroid therapy. MTX therapy was initiated in 8 patients at a dose of 40 mg given intravenously once weekly for 4 weeks followed by 15 mg/week given orally; 6 subjects were started on the oral regimen of 15 mg/week. During a follow-up period of 3-24 months, intraocular inflammation improved in all subjects under immunosuppressive therapy with MTX. A concomitant improvement in visual acuity was observed in 11 patients. Side effects included slight elevations in transaminases in 4 patients, transient mucositis in 1 case, partial alopecia in 2 subjects, and nausea in 3 patients. Our initial results suggest that low-dose MTX therapy may be considered as a therapeutic modality in noninfectious, steroid-refractory uveitis.

Administration, Oral↗

PubMed1991

[Uveitis: occurrence in rheumatic diseases and immunosuppressive therapy].

In 13/53 patients with uveitis an associated rheumatic condition was found. An infectious etiology could be assumed in 3/53 cases. Methotrexate was used in noninfectious uveitis in 11/53 cases, who were refractory to high doses of systemic steroids: all improved, 5 patients achieved complete remission.

Adult↗