[A case of solitary tuberculoma of the liver and a review of the Japanese literature on the morphological characteristics in the images].
Explore the source record for details and available documents.
Female↗
Biomedical subjects
M Seki
Publications and source records attributed to M Seki.
An actin-interacting heptapeptide in the cofilin sequence.
Cofilin, a 21-kDa actin-binding protein, has a hexapeptide sequence DAIKKK which is identical to the N-terminal portion (residues 2-7) of tropomyosin. The synthetic heptapeptide, DAIKKKL, corresponding to residues 122-128 of cofilin, inhibited the binding of cofilin to F-actin in a dose-dependent manner. The heptapeptide cosedimented with F-actin, decreased the fluorescence intensity of pyrene-labeled F-actin, and increased the rate of polymerization of G-actin. The hexapeptides, DIKKKL and DAIKKL, also inhibited the binding of cofilin to F-actin and affected the fluorescence intensity of pyrene-labeled F-actin and the rate of actin polymerization, like the heptapeptide. However, their effects were weaker than those of the heptapeptide. Moreover, the pentapeptide, DIKKL, had little or no effect. These results suggest that the heptapeptide sequence is specific for the interaction with actin and, therefore, may constitute part of the actin-binding domain of cofilin.
Acrylic Resins↗
Observation of ion-cyclotron-wave instability caused by perpendicular neutral beam injection in the JT-60 tokamak.
Explore the source record for details and available documents.
Journal Article↗
An ultrasonographic method for detection of Achilles tendon xanthomas in familial hypercholesterolemia.
The diagnosis of familial hypercholesterolemia (FH) is frequently made on clinical grounds and detection of tendon xanthomas is crucial for that. In order to clarify whether ultrasonography (US) can be used as a reliable and practical method for detection of Achilles tendon xanthomas in FH, the Achilles tendon thickness in the sagittal section was examined by US in 15 patients with heterozygous FH and 34 normocholesterolemic subjects. US visualized clearly the anterior and posterior borders of the Achilles tendon. The Achilles tendon thickness determined by US correlated with that measured by conventional radiography (r = 0.99). The mean values +/- SD of the Achilles tendon thickness determined by US were 4.5 +/- 0.5 mm in the normal controls and 11.9 +/- 5.1 mm in the patients and the difference was significant (P less than 0.001). In 13 of 15 patients, US visualized thickened Achilles tendons with convex shape in the sagittal section. All the thickened Achilles tendons revealed by US were confirmed by radiography. The data indicate that US can detect Achilles tendons thickened by xanthomas. We conclude that US is a useful aid in the clinical diagnosis of FH.
Achilles Tendon↗
Correlation of serum inhibin concentrations with results in an ovarian hyperstimulation program.
In order to appraise follicular development, human serum inhibin was measured daily by radioimmunoassay in 18 women undergoing ovarian hyperstimulation. Serum inhibin in the early follicular phase correlated with the number of follicles greater than or equal to 17 mm in diameter (r = 0.57, n = 18, P less than 0.05), follicles greater than or equal to 14 mm in diameter (r = 0.67, n = 18, P less than 0.01) on the day of human chorionic gonadotropin (hCG) administration and the number of oocytes retrieved (r = 0.67, n = 15, P less than 0.01). The number of oocytes retrieved showed a significant correlation with serum inhibin level on the day of hCG administration (r = 0.84, n = 15, P less than 0.001). These data suggest that: (1) In the early follicular phase, serum inhibin may be a valid index to predict ensuing follicular growth; (2) In the preovulatory phase, serum inhibin may be one of applicable indexes of follicular development during the hyperstimulation cycle.
Adult↗
Membranoproliferative glomerulonephritis in Japan.
Explore the source record for details and available documents.
Glomerulonephritis, Membranoproliferative↗
[The effect of hypotensive anesthesia with nitroglycerin and verapamil on platelets].
Recently, there have been many cases in which nitroglycerin (TNG) is used for anesthesia for patients with low blood pressure. Since, it has been reported that TNG suppresses the platelet aggregation function in vitro. Verapamil (Vp), known as another platelet aggregation suppressant, and nicardipine (Nc) were used together with TNG and the platelet aggregation function was studied in vitro and in vivo. The results of the in vitro experiment showed that TNG 250 ng.ml-1 + Vp 250 ng.ml-1 suppressed the platelet aggregation function, and when TNG + Vp (was used for low hypotensive anesthesia, a large amount of Vp i.e. over 15 mg of Vp is injected as a bolus into the artery, there is a possibility the platelet aggregation function will be suppressed. No platelet aggregation function suppression was found when TNG+Nc was used in hypotensive anesthesia.
Drug Combinations↗
[A case of hepatocellular carcinoma with a duodenal invasion from metastatic lymph node].
A 64-year-old male, who had been diagnosed as having hepatocellular carcinoma, was admitted to hospital and underwent transcatheter arterial infusion therapy. CT and US examinations revealed a large tumor with air in its center. Barium meal examination of the duodenum showed a large filling defect with a central excavation. At endoscopic examination, a dark reddish tumor was seen protruding into the duodenal lumen. A biopsy specimen from this tumor revealed a hepatocellular carcinoma. The patient subsequently died of hepatic coma following gastrointestinal bleeding. An autopsy revealed that metastatic lymph nodes had infiltrated into the adjacent duodenum. Nine previous cases of duodenal metastasis from a hepatocellular carcinoma have been reported in the Japanese literature.
Biopsy↗
[A case of hepatocellular carcinoma (HCC) with a huge tumor thrombus in the right atrium].
A case of HCC with a huge tumor thrombus in the right atrium is reported. CT and celiac angiography revealed HCC in the liver. Inferior vena cavography and cardiac blood pool scintigraphy demonstrated a large defect in the right atrium, and 67Ga-citrate scintigraphy showed a lesion of abnormal accumulation in the right atrium. With these findings, diagnosis of HCC with a tumor thrombus in the right atrium was made, and the clinical diagnosis was confirmed by autopsy.
Carcinoma, Hepatocellular↗
[Changes in complement breakdown products and terminal complement complex in patients with acute glomerulonephritis].
In this study we examined the role of the complement system in acute glomerulonephritis (AGN). Breakdown products of complements (iC3b, C4d and Bb) and Terminal complement complex (TCC, SC5b-9 complex) in plasma samples were measured by ELISA. The microassay plates were coated with monoclonal antibodies which bind specifically to human iC3b, C4d, Bb and SC5b-9 complex. This assay accurately quantitates small amounts of in vivo complement activation. The plasma samples were drawn from patients with AGN and other glomerulonephritis. There were some patients with various glomerulonephritis whose plasma iC3b, C4d and Bb concentrations were higher than those in normal human. However specificity was not found. The ratios iC3b/C3 and C4d/C4 were increased in the early stages of AGN, but plasma Bb concentrations revealed no significant changes. Plasma SC5b-9 complex concentrations were increased in the early stages of AGN. C3c, C3d, C4d and SC5b-9 were found to be localised in the glomeruli of those AGN patients. It is suggestive that in these cases of AGN (especially case 2) complement activation is predominantly mediated through the classical pathway and TCC is formed by this activation. This complement activation in the blood and the renal tissue is presumed to be involved in the initiation and progression of AGN.
Acute Disease↗
[Spontaneous spinal epidural hematoma diagnosed by MRI: a case report].
Appropriate diagnostic procedure for spinal epidural hematomas has not been established yet. The authors reported a case of spontaneous epidural hematomas at the thoracic level, in which correct diagnosis was made with MRI and good results were obtained by surgery. A 63-year-old female experienced a severe back pain which appeared suddenly during a walk and was followed by motor weakness in both legs deteriorating quickly to paraplegia. The patient had no history of hypertension, trauma or bleeding tendency. The laboratory data were normal. On admission, neurological examination revealed flaccid paraplegia, total sensory loss below the level of Th 6 and urinary and fecal incontinence. Myelograms showed incomplete block at the Th 6 level and postmyelographic CT scan showed an isodense mass, which was suspected to be an epidural tumor located behind the spinal cord. Emergent MRI confirmed an epidural hematoma as a high intensity area extending from Th 3 through Th 11. Sixty-five hours after onset, laminectomy of Th 4 through Th 11 and the evacuation of epidural hematoma were performed without identification of the origin of the bleeding. Neither vascular malformation nor tumor was recognized during operation. Neither was it noticed on histological examination. The patient made favorable progress after the surgery. During the first two weeks in the postoperative period, she regained muscle strength enough to do standing exercise, and satisfactory improvement was made in sensory function including urination and defecation. We emphasize that MRI is indispensable to make a differential diagnosis of thoracic lesions. In the reported case, a correct diagnosis was made with MRI, and an extremely good result was obtained by an emergency operation.
Female↗
Radiation-induced neoplastic transformation of C3H10T1/2 cells is suppressed by ascorbic acid.
X-ray induced transformation of C3H10T1/2 cells was suppressed in a concentration-dependent manner by administration of ascorbic acid after irradiation (0.1-20 micrograms/ml for the first week) in the culture medium. The dose-response curve was shifted about 60% downward and was slightly steeper in the presence of ascorbic acid (5 micrograms/ml for the first week) than in its absence. The 1-week treatment procedure revealed that cells initiated by radiation remained susceptible to ascorbic acid until the time of morphological phenotype expression. The neoplastically transformed phenotype expressed after incubation for 8 weeks could no longer be suppressed by ascorbic acid even after culture transfer. Similarly, the neoplastically transformed phenotype suppressed for 8 weeks by ascorbic acid treatment was not subsequently expressed in the absence of ascorbic acid. On the basis of the oxygen-detoxifying nature of ascorbic acid, we postulated that expression of the neoplastically transformed phenotype is promoted by reactive oxygen species and peroxy radicals generated in cells during the whole assay period. The data may be useful as a guide for chemopreventive efforts against radiation carcinogenesis.
Animals↗
[A case of Ehlers-Danlos syndrome].
Ehlers-Danlos syndrome, an inherited connective tissue disorder, is characterized by skin hyperextensibility, joint hypermobility and skin fragility. The disease is at least classified into 10 types, I to X, based on clinical features, biochemical abnormalities of the connective tissue and the mode of inheritance. A case is reported of a 6-year, 8-month-old girl who showed the features of the Ehlers-Danlos syndrome type VII. The findings were as follows: 1) Soft and velvety touch skin, characteristic joint hypermobility, talipes varus, and ventricular septal defects were present. 2) Widely set eyes, slight stabismus, epicanthal folds of the eyes, antimonogoloid slanted eyes, a broad bridge to the nose and low set ears were observed. 3) Gingival bleeding following toothbrushing, Enamel hypoplasia, high arched palate and laxity of the temporomandibular joint were present. 4) In the findings of the maxillary and mandibular dental arches, there was no tendency towards conical teeth in the deciduous dentition, and the width and length of the dental arches were remarkably narrow and short. 5) The roentogenographic findings revealed that there were no minor root deformities, pulpstones and calcification of the pulp. 6) The measurement of the width, length, and depth of the palate through moiré topography revealed that the palate was narrow and deep compared with the control. 7) As a result of cephalometric diagnosis, the nasion appeared to be protruded, therefore maxillary and mandibular seemed to be relatively retracted, and the gonial angle was obtuse. The dental management of patients with Ehlers-Danlos syndrome was discussed and reviewed.
Child↗
[A case of right aortic arch with the stenotic left subclavian artery at its origin complaining of left nuchal pain].
A 25 year-old male was transfered to our department with a complaint of left nuchal pain. Angiography revealed a right aortic arch with the stenotic left subclavian artery at its origin and poor left vertebral artery. The anomaly was classified an intermediate type of Stewart type (2) and (3). It was very rare and we have found only 3 same cases in literature. The complaint disappeared after the ascending aorto-left subclavian artery bypass.
Adult↗
C3 nephritic factor and C4 nephritic factor in the serum of two patients with hypocomplementaemic membranoproliferative glomerulonephritis.
Both C3 nephritic factor (C3NeF) and C4 nephritic factor (C4NeF) were found in the serum of two patients with hypocomplementaemic membranoproliferative glomerulonephritis type 1 (H-MPGN type 1). Both stabilizing activities were associated with the IgG fraction. The serum levels of C3 and C5 were quite low, whereas the levels of early components and control proteins were in the normal range.
Adolescent↗
[A case of sarcoidosis associated with membranous nephropathy].
A 59-year-old woman was admitted to the hospital with a complaint of right visual disturbance. At admission, she had proteinuria and microscopic hematuria. The pulmonary X-ray showed bilateral hilar lymphadenopathy (BHL) but tuberculin test were negative. Also, bronchoalveolar lavage (BAL) and renal biopsy were performed. Bronchoalveolar lavage fluid (BALF) contained a high percentage of OKT 4 positive cells. In renal biopsy, light microscopic study showed thickening glomerular basement membrane (GBM) with tubulo-interstitial legion. Immuno-fluorescent study revealed granular deposits of IgG along glomerular capillary wall. Electron microscopic study showed subepithelial electron dense deposits of GBM, which are characteristic for membranous nephropathy (MN). It is well known that both sarcoidosis and MN are associated with immunological abnormality. This case might be significant for the study of pathogenesis of sarcoidosis.
Female↗
[Activation of complement by hemodialysis membrane].
Incubation of normal human serum with hemodialysis membranes in vitro resulted in conversion of C3 which was detected by crossed immunoelectrophoresis. In addition, formation of C3d was also observed, as was detected by double-decker rocket immunoelectrophoresis. Furthermore, breakdown products of complement (iC3b, C4d & Bb) in plasma samples were measured by ELISA. The microassay plates were coated with monoclonal antibodies which bind specifically to human iC3b, C4d and Bb, respectively, while the plasma samples were drawn from five polycystic kidney patients during initial hemodialysis. As a result, the iC3b and Bb levels in plasma were seen to increase during hemodialysis but the C4d levels revealed no significant changes. It was also observed that the Bb levels in patients undergoing hemodialysis were significantly higher than those in various renal and collagen diseases. Terminal complement complex (TCC) was not present in detectable amounts in normal human serum when measured by ELISA. However, incubation of normal human serum with hemodialysis membranes in vitro resulted in detection of TCC. TCC was present in the same plasma samples drawned from the five polycystic kidney patients during initial hemodialysis. It is suggestive that activation of complement by hemodialysis membrane is predominantly mediated through the alternative pathway and products such as TCC and anaphylatoxin are formed by this activation.
Complement Activation↗
[Intra-arterial chemotherapy with angiotensin II in metastatic carcinoma of the liver using implantable pump].
Nine patients with metastatic carcinoma involving the liver were treated by hepatic arterial chemotherapy with Angiotensin II (AGT II) using a subcutaneous implanted pump. There were two primary lesions in the breast, one in the stomach, three in the colon and three in the rectum. Every patient received intra-arterial bolus injection of 5-FU and Adriamycin with 3 mcg of AGT II weekly at our outclinic. Of 7 evaluable patients, 6 responded clinically with PR (response rate, 85.7%). No adverse effects were noted in relation to AGT II. AGT II combined with chemotherapy is therefore a safe and effective method for even outpatients with liver metastases.
Adult↗