Biomedical subjects

M Selinger

Publications and source records attributed to M Selinger.

29 records · Page 2Linked to original sources

PubMed1989

Production of additional atypical alloantibodies in Rh(D)-sensitized pregnancies managed by intrauterine investigation methods.

The production of additional atypical alloantibodies by previously Rh(D)-alloimmunized antenatal patients can complicate the clinical management of both mother and fetus. The relative risks of stimulating additional antibodies following the use of intrauterine investigation methods currently used for the management of haemolytic disease of the newborn have been assessed. A significantly (P less than 0.05, X2) greater number of additional antibodies were detected during pregnancy in the group of pregnancies managed by intrauterine transfusion (IUT) (3/29) than in those managed without recourse to intrauterine investigation (0/50), although one of the patients in the IUT group produced a further antibody following a fetal blood sample but before an IUT had been carried out. The number of additional antibodies detected post-delivery was significantly greater (P less than 0.02) in pregnancies managed by intrauterine transfusion (2/10) than in those managed by fetal haematocrit determination alone (0/28).

Blood Specimen Collection↗

PubMed1988

Serial fetal blood sampling for the management of pregnancies complicated by severe rhesus (D) isoimmunization.

Fifty-one pregnancies complicated by rhesus (D) isoimmunization have been managed by serial fetal blood sampling between 17 and 36 weeks gestation as an alternative to amniocentesis for delta OD453 measurements. In 36 pregnancies where the fetus was shown to be rhesus (D) positive and both measurements were made before any intrauterine fetal transfusions, the delta OD453 value gave misleading predictions on 13 of 63 occasions (21%). Fetal haematocrit estimations provided a direct assessment of the haemopoietic compensation occurring, but fetal bilirubin and albumin concentrations did not correlate directly with disease severity. It is proposed that pregnancies complicated by severe isoimmunization can be more precisely managed by serial fetal blood sampling for haematocrit estimation than amniocentesis for delta OD453 measurement thus avoiding unnecessary intervention or delayed treatment.

Female↗

PubMed1988

Antenatal fetal blood sampling for the management of alloimmunized pregnancies: effect upon maternal anti-D potency levels.

Increase in maternal anti-D concentrations after intrauterine investigation has been studied retrospectively in 95 rhesus (D) alloimmunized pregnancies; 48 were managed by fetal blood sampling (FBS) procedures (using fetoscopy or ultrasound-guided needle sampling) and 47 using amniocentesis. In those pregnancies where the fetus was rhesus (D) positive, the frequency of procedure-related increases (greater than 50%) in maternal anti-D potency was estimated following single procedures and found to be similar for the two methods of FBS employed (28%) and for amniocentesis (31%). The proportion of pregnancies showing an increase in anti-D potency was higher after ultrasound-guided needle sampling (75%) than after fetoscopic FBS (40%) and after amniocentesis (44%).

Amniocentesis↗

PubMed1988

The effect of epostane, a 3-beta hydroxy steroid dehydrogenase inhibitor, on maternal and fetal steroid levels during mid-gestation.

A double-blind, placebo-controlled trial was conducted to assess the maternal and fetal endocrine effects of epostane, an inhibitor of progesterone synthesis, in mid-pregnancy. Although present in the maternal circulation, epostane was not detected in cord blood or amniotic fluid. Maternal and fetal progesterone levels fell by 80% and 95% respectively with maintenance of the fetal arterio-venous difference while oestradiol and aldosterone levels were affected to a lesser extent. The mechanism of 3-beta hydroxy steroid dehydrogenase suppression and the relation between fetal and maternal progesterone levels are discussed.

3-Hydroxysteroid Dehydrogenases↗

PubMed1988

Cueing verbs: a treatment strategy for aphasic adults (CVT).

This investigation demonstrated that the treatment protocol, "Cueing Verbs: A Treatment Strategy for Aphasic Adults" (hereafter referred to as CVT), was an effective rehabilitation technique. Specifically, this CVT was shown to be beneficial with marked/moderate to mild fluent aphasic adults. Additionally, the study addressed such issues as optimal treatment frequencies, treatment initiation and termination points, and criteria for success and failure. Finally, the six-tier hierarchy of treatment levels are presented with all variables operationally defined.

Aged↗

PubMed1987

Progesterone inhibition in mid-trimester termination of pregnancy: physiological and clinical effects.

A double-blind, placebo controlled clinical trial was conducted to assess the clinical and physiological effects of 'epostane', a progesterone synthesis inhibitor, in mid-trimester prostaglandin termination of pregnancy. Mean peripheral progesterone levels had fallen by 74% after 72 h in the patients treated wtih epostane. The mean induction-abortion interval in the treatment group was 490 (SD 271) min, compared with 1432 (SD 640) min in the control group. Intrauterine pressure recording demonstrated increased sensitivity to prostaglandin E2 after epostane treatment but no change in oxytocin sensitivity. The clinical implications of facilitated induction of abortion are discussed.

Abortifacient Agents↗

PubMed1979

Quality control of the latex-fixation test.

Standardization of the latex-fixation test for the detection of rheumatoid factor may be achieved by the preparation of a standard reference serum. A number of guidelines for the quality control of precision and sensitivity of the test are suggested. In the use of dilution procedures, a 0.1 log10 or a 0.05 log10 difference between tubes is employed. The end point is defined and titer expressed in terms of a final dilution represented by the amount of antigen-antibody added. For statistical purposes all serologic data are geometrically expressed. Commercial kits may be standardized in terms of minimum detectable units and normalized for titer and unit values to enable laboratories to compare results.

Humans↗

PubMed1975