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Biomedical subjects

M Semczuk

Publications and source records attributed to M Semczuk.

At least 19 recordsLinked to original sources
PubMed2004

A rare case of pregnancy and delivery of a healthy neonate by a woman with microprolactinoma and review of the literature.

A rare case of a term-pregnancy and delivery in a patient with microprolactinoma is presented. The patient had been treated with bromocriptine since she was 17 due to primary amenorrhea for 60 months with short intervals. Pharmacological tests with dopamine antagonists and X-ray diagnostics revealed the presence of microprolactinoma. The patient was constantly under specialist endocrinological care and the level of prolactin in her blood serum was continuously being monitored. After getting pregnant she was placed under strict gynecological scrutiny with special attention devoted to the developing fetus and possible congenital defects. The patient continued receiving bromocriptine therapy up to the 16th week of pregnancy. In the course of pregnancy in the 26th week, a circular suture was placed on the uterine cervix due to symptoms of isthmus-cervical insufficiency. In the 38th week of pregnancy a cesarean (C) section was performed and a healthy child in good general condition (Apgar score 10) was born. The child weighed 2,900 grams.

Adult↗
PubMed2001

Influence of magnesium sulphate and isradipine on human placental cotyledon fetal vessels in vitro.

Increased systemic vascular resistance and blood pressure during pregnancy may be due to impaired prostacycline PGI(2)-thromboxan (TX) A(2) balance. The aim of the study was to compare the influence of magnesium sulphate and isradipine on the placental vascular resistance induced by stable thromboxan A(2) analogue U 46619 in experimental bilateral perfusion of the human placental cotyledon. The research used the experimental model described by Schneider et al. [Am. J. Obstet. Gynecol. 114 (1972) 822]. The control group consisted of six placental lobule perfusions lasting 120 min each. Constant increase in perfusion pressure of mean value 185% of the initial pressure was obtained from about the 60th min of the experiment and maintained till the end. Having obtained constant increase in perfusion pressure from the 60th min of the experiment, magnesium sulphate and isradipine were administered along with thromboxan A(2) analogue U 46619 into the fetal circulation. Both drugs lowered perfusion pressure, experimentally increased by thromboxan A(2) analogue U 46619. The onset of magnesium sulphate activity was quicker than isradipine. According to the results of our in vitro study, magnesium sulphate and isradipine may have a beneficial effect on vascular resistance of cotyledon vessels in PIH in vivo, too.

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5↗
PubMed2001

[Management in premature rupture of the membranes (PROM) at term--own experiences].

UNLABELLED: In our study the management and outcomes in 211 women with premature rupture of the membranes at term was analyzed. According to the time elapsed since PROM to delivery the study group was divided into four groups: within 6 h, within 6-12 h, within 12-24 h and over 24 h after PROM. The analysis was focused on the maternal age, obstetric history, induction of labor, mode of delivery, duration of interval between PROM and active labor, use of maternal antibiotics, newborns evaluation in Apgar score and the neonatal infections. CONCLUSIONS: 1. In our study PROM at term occurred more frequently in primigravidae than in multigravidae. 2. The relationship between duration of time from the membranes rupture to delivery and frequency of labor induction, use of maternal antibiotics and neonatal infections was observed. 3. The higher percentage of cesarean sections in patients with interval from PROM to delivery less than 6 and over 24 hours was found.

Adult↗
PubMed2001

[Use of amnion in the treatment of anterior segment diseases of the eye].

PURPOSE: The aim of this study is to present the results of treating the anterior segment of the eye with amnion membrane transplantation (AMT). MATERIALS AND METHODS: 16 patients were treated with amnion membrane transplantation because of: pemphigoid ocularis, combustio chaemica, ulcus corneae, keratopathia bullosa, descemetocele, symblepharon, graft disease. Histopathological investigations were performed by the use of impression cytology. RESULTS: In 4 patients we obtained only temporary improvement. In 12 patients the treatment was successful with complete reepithelialization of the cornea and the conjunctiva. The impression cytology study showed an intensive regeneration of the corneal and conjunctival epithelium.

Adult↗
PubMed2001

[Management and outcome of preterm labor in department of obstetrics and pathology of pregnancy school of medicine in Lublin].

OBJECTIVES: We present data of three years experience of management and outcome of preterm labour. MATERIALS AND METHODS: The study comprised 335 pregnant women with preterm labour. We analyzed the pharmacological therapy and way of labour. There were two groups of patients: I group--180 patients who had cesarean delivery, II group--155 patients who had vaginal delivery. RESULTS: It has been found 7.54% more cesarean delivery than vaginal delivery of preterm labour.

Adolescent↗
PubMed2001

Influence of antisperm antibodies on T cell adhesion to extracellular matrix proteins in women with a history of unexplained infertility.

beta 1 integrins, receptors responsible for the binding of extracellular matrix proteins, mediate activation, adhesion, migration and differentiation in different tissue compartments. It has been recently demonstrated that integrins are distributed on sperm surface and on T cells, as well. The aim of this study was to establish influence of antisperm antibodies on T cell adhesion to extracellular matrix proteins in women with a history of unexplained infertility.

Adult↗
PubMed2000

[Urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in women with preeclampsia].

OBJECTIVES: Preeclampsia is the pregnancy specific disorder in which reduced organ perfusion and ischemia of the kidney, liver and brain can be detected. In the kidney, the most typical anatomopathological lesion is glomerular endotheliosis but renal tubular damage was also demonstrated. The NAG is an enzyme which is released into urine from the lysosomes of the proximal renal tubules epithelium and therefore increased urinary NAG activity is a marker of tubular damage or dysfunction. DESIGN: The aim of the study was to assess the renal tubular damage in women with preeclampsia by measuring of urinary NAG activity. MATERIALS AND METHODS: The study group consisted of 46 pregnant women in third trimester with preeclampsia. 36 normal pregnant women in third trimester and 26 healthy nonpregnant women served as two control groups. Urinary activity of NAG was measured in the second morning urine sample by colorimetric method and the results were expressed as NAG/creatinine ratio (U/mmol). RESULTS: Urinary NAG/creatinine ratio was increased in normal pregnant women in third trimester (0.77 +/- 0.44 U/mmol) exceeding that of nonpregnant women (0.23 +/- 0.16). In women with preeclampsia, the urinary NAG/creatinine ratio was significantly higher when compared to the normal pregnant women in third trimester (1.46 +/- 1.63 U/mmol). There were no correlation between urinary NAG excretion and blood pressure results in women with preeclampsia. CONCLUSIONS: The increased urinary NAG activity in women with preeclampsia seems to be a sign of proximal tubular damage. The renal function follow up study in such women is indicated.

Acetylglucosaminidase↗
PubMed2000

[Influence of captopril on hemodynamics of human placenta in vitro].

OBJECTIVES: Captopril, an agiotensin converting enzyme inhibitor (ACEI) is widely used drug in antihypertensive treatment. After maternal therapy with ACEI several adverse effects on fetus and neonate have been described but the patomechanism is not well known. DESIGN: The purpose of the study was to determine the effects of varying Captopril concentrations on the perfusion pressure in fetal vessels in the in vitro placental double-sided perfusion model. MATERIALS AND METHODS: Human placental cotyledons from term normal pregnancies were perfused with 100 ng/ml and 1000 ng/ml of Captopril. The perfusion pressure in fetal circuit in every 30 minutes of 3-hours experiment was measured. RESULTS: The highest mean perfusion pressure in fetal circuit was observed in placentas perfused with Captopril in the dose of 100 ng/ml, whereas Captopril in the dose of 1000 ng/ml significantly decreased perfusion pressure after 180 minutes of the experiment. CONCLUSION: The decrease in perfusion pressure in fetal vessels after relative high dose of Captopril may indicate its direct or indirect influence on capillaries.

Adult↗
PubMed2000

[Sex and changes in mu-opioid receptor density under hypoxia].

The opioid system modulates the growth and development of CNS. Hypoxia increases endogenous opioids significantly. The density and distribution of mu-opioid receptors in MPOA is cyclical and sexually dimorphic. To test the hypothesis that perinatal hypoxia affects the development of the opioid receptor system in fetus brain in both sexes differentially, we performed the following study. We divided 24 pregnant Sprague-Dawley rats to two treatment groups and control group. We exposed one group (CH) to chronic prenatal hypoxia (10.5% O2) continuously 24 h/day and second group (AH) to acute, intermittent hypoxia (9.0% O2) 6 h/day from day E15 to E20. We analyzed the brain regions: CPu, ZG, NA, OT, MMPoA, LMPoA by quantitative autoradiography following incubation with (3H) DAMGO. We didn't notice any significant changes in mu-opioid receptor density between sexes in selected brain regions. We found mu-opioid receptor a significant changes in mu-opioid receptor of all brain regions in female group.

Acute Disease↗
PubMed2000

[Analysis of twin pregnancies in material from the Department of Obstetrics and Pathology of Pregnancy in Lublin from 1991-1998].

The course of multiple pregnancies and multiple fetus labor were analyzed in 111 women delivered in the Department of Obstetrics, School of Medicine in Lublin in the years 1991-1998. It has been found that the most frequent patients were those aged 25-29 coming from the cities and after the infertility treatment. The aim of this research was to characterize twin pregnant patients, and present the outcome of multiple pregnancy. The studies were performed on 67 women from the cities and 44 women from the villages. It is significant that almost 55% pregnant women underwent the cesarean section and their average birth weight was 2490 g. These results indicate that multiple pregnancy is in high risk pregnancy.

Adult↗
PubMed1998

Dietary factors in women with dysplasia colli uteri associated with human papillomavirus infection.

The studies were carried out in a group of 228 female patients with normal cytological smear and 324 patients with cervical intraepithelial neoplasia (CIN). The applied method of human papillomavirus (HPV) identification, i.e., the HPV digene hybrid capture system, made it possible to select a control group consisting of 168 HPV-negative patients with normal Papanicolaou smears, as well as a group of 228 HPV-positive female patients with CIN. By examining the diet of the patients, it was shown that women with cervical dysplasia associated with high oncogenic risk of HPV infections consumed a smaller quantity of foods containing vitamin C, beta-carotene, and folacin. Our studies indicate a relationship between nutritional habits and the development of CIN associated with HPV infection.

Animals↗
PubMed1998

[Comparison of changes in optical density of mu-opioid receptors in the brain of adult rats after prenatal and postnatal hypoxia].

UNLABELLED: The opioid system modulates the growth and development of CNS. Hypoxia increases endogenous opioids significantly. The early development of the opioid receptor system has been reported to be susceptible to perinatal opioid exposure so the developing brain may be influenced by circulating opioids. To test the hypothesis that perinatal hypoxia affects the development of the opioid receptor system in developing brain, we performed the following study. We divided 36 pregnant Sprague-Dawley rats to three treatment groups and control group. We exposed one group (C) to chronic prenatal hypoxia (10.5% O2) continuously 24 h/day and second group (AH) to acute, intermittent hypoxia (9.0% O2) 6 h/day from day E15 to E20. Group of newborns (PH) we exposed to postnatal hypoxia (10.5% O2) from day P2-10. We analyzed the several brain regions: CPu, NA, MMPoA, LMPoA, CA3, VM, AH, Habenula by quantitative autoradiography following incubation with (3H) DAMGO. RESULTS: 1) Chronic prenatal hypoxia decreased mu-receptor binding in all brain regions examined. 2) In contrast, mu-receptor binding following acute, intermittent hypoxia tended to be increased in the several brain regions. 3) Postnatal hypoxia did not change mu-receptor binding in characteristic way. 4) Such receptor changes may be associated with endocrinologic or behavioral abnormalities.

Acute Disease↗
PubMed1998

[Amniotic band syndrome: a case study].

This study present a case of a female newborn, gestational age (GA)--27 weeks, birth weight--1020 g (50 percentile), body length--38 cm, head circumference--26 cm, chest circumference--24 cm. The newborn came from the first pregnancy, the amniotic fluid leak was observed for 7 days before delivery resolved by cesarean section. The following consequences of the amniotic band syndrome were observed in the newborn: congenital amputation of lower left limb, congenital amputation of 2nd, 3rd, 4th, 5th fingers in the upper right limb, congenital constricting ring of 1 finger in the upper right limb, congenital amputation of 1st toe in the lower right limb, syndactylism of fingers of upper and lower limbs. The above malformations will be presented and supported by photographic, ultrasound and radiographic documentation.

Abnormalities, Multiple↗
PubMed1998

[Selected endocrinological problems in mature and elderly men].

Aging of human organism is usually related with a decline of gonadal activity. Age associated reproductive and hormonal changes in men are not as dramatic and clear as in women. During the process of physiological aging three hormonal systems show the decrease in circulating hormone concentrations: estrogen (menopause), testosterone (andropause) dehydroepiandrosterone sulfate (adrenopause) growth hormone and it's tissue mediator IGH-I (somatopause). Emphasizing the probable causes of hypoandrogenism consequences of the above hormonal shortage have been presented. Additionally some factors participating in the process of human organism aging have been discussed.

Adult↗
PubMed1998

[Frequency of human papillomavirus-herpes simplex-cytomegalovirus and Chlamydia trachomatis infection in genital tracts of sexual partners].

OBJECTIVES: Much attention is given nowadays to the role of Human Papillomavirus, Herpes simplex virus, Cytomegalovirus, and Chlamydia trachomatis--infections in cervical carcinogenesis. Cytomegalovirus, Herpes simplex and Chlamydia trachomatis are now thought to be teratogenic to humans. DESIGN: We investigated the prevalence of HPV, HSV, CMV and Chlamydia trachomatis in genital tracts of sexual partners. MATERIALS AND METHODS: 90 sexual partners were qualified for the research. Examination smears were taken with the dacron swab from the vaginal part of the uterine cervix, cervical canal, the lower vagina from women and from fossa navicularis penis in men. In the group of 67 men we have investigated semen as well. HPV, HSV, CMV and Chlamydia trachomatis were identified using PCR (Polymerse Chain Reaction)--method. RESULTS AND CONCLUSIONS: In 48% of investigated sexual partners we proved the presence of Human Papillomavirus, in 2.2% of women and 2.9% of men--Cytomegalovirus and in 11.1% of women and 14.9% of men--Chlamydia trachomatis. In the investigated biological material we did not find any HSV infection.

Chlamydia Infections↗
PubMed1998

[The detection of CFTR gene mutation in patients with azoospermia].

Cystic fibrosis (CF) is the most common autosomal recessive disorder in Caucasian population that involves the lungs, pancreas, sweat glands, intestine, liver and reproductive tract. The majority of men with CF are infertile due to a bilateral congenital absence of the vas deferens (CBAVD). The purpose of the research was to evaluate the occurrence frequency of alleles of CFTR gene in patients with azoospermia. Twenty four men from sterile marriages were examined in whom spermatozoa were not found in 2-3 successive examinations of their semen. In every patient the basic concentration in blood of FSH, LH, PRL and testosterone was determined and ultrasonography of gonads, vas deferens, prostate and spermatic vesicles was performed. The INNO-LIPA CF2 test was used to the screening for the eight most frequently identified mutations in Caucasian population: DF508, G542X, N1303K, 1717-1(G- > A), W1282X, G551D, R553X i DI507. The test is based on the reverse-hybridization method. Carrier-state of one mutated allele was detected in 3 men (12.5% examined causes). In two men DF508 mutation and in one W1282X mutation were detected. The data suggest that the CFTR protein may be involved in the process of spermatogenesis apart from playing a critical role in the development of the vas deferens.

Adult↗
PubMed1997

Content of alpha-tocopherol in blood serum of human Papillomavirus-infected women with cervical dysplasias.

The studies were carried out in a group of 228 female patients with normal cytological smear and 324 patients with cervical intraepithelial neoplasia. The applied method of identification, i.e., the human Papillomavirus (HPV) digene hybrid capture system, made it possible to select a control group consisting of 168 HPV-negative patients with normal Pap smear, as well as a group of 228 HPV-positive patients with cervical intraepithelial neoplasia. The high-performance liquid chromatography method was employed to evaluate the level of alpha-tocopherol in the blood serum of the patients who were examined. A statistically significantly lower level of alpha-tocopherol was observed in the blood serum of HPV-positive patients with cervical intraepithelial neoplasia. The risk of dysplasia was four times higher for an alpha-tocopherol level < 7.95 mumol/l.

Chromatography, High Pressure Liquid↗