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Biomedical subjects

M Semonský

Publications and source records attributed to M Semonský.

At least 37 records · Page 2Linked to original sources
PubMed1976

Changes in the concentration of adenohypophyseal prolactin and morphological manifestations in the adenohypophysis of lactating rats after administration of D-6-methyl-8-[beta-isopropylaminoethyl] ergoline-I.

The four days administration of D-6-methyl-8-[beta-isopropylaminoethyl]ergoline-I (VUFB-10726) to nursing rats decreases adenohypophyseal prolactin as determined with disc electrophoresis, and produces changes in the histological appearance of adenohypophyses, which indicate the inhibition of prolaction production and secretion.

Animals↗
PubMed1975

Effect of ergoline derivative VUFB-6638 on the adenohypophysial prolactin concentration in rats.

The compound VUFB-6638 (N-/D-6-methyl-8-isoergolin-I-yl/N'-N'-diethylurea hydrogen maleinate) was administered for four consecutive days to lactating rats in daily oral doses of 0.1, 1.0 and 2.0 mg/kg. The adenohypophysial prolactin concentration decreased by 34% to 68%, respectively. Moreover, this compound reduced or even completely suppressed the lactation. In view of the assumed relations between prolactin and breast carcinoma, a potential use of the drug is noted.

Animals↗