Biomedical subjects
Publications and source records attributed to M Seremet.
The activity of zinc-oxide paste on histologic changes of the pulp was examined while the indirect capping of the exposed dog tooth pulp was performed. The results showed that the histologic changes observed in dog tooth pulp were accompanied with hyperaemia and blood vessel dilatation then with the pulp oedema, slight disorder of odontoblast palisade and the presence of the traces of occurrence of tertiary dentin.
In 45 histologically verified breast cancer patients the cell-mediated immune responses were tested prior to surgical therapy. The cell immunity was assessed by the percentage of T and active T-lymphocytes and by measuring the lymphocyte reactivity to phytohemagglutin (PHA) and concanavalin A (Con A). Disease-free interval was longer and the mortality after 3, 5 and 8-year follow-up significantly lower in the group of patients with the normal number of T and active T-lymphocytes than in the group of patients with the lower number of those cells. The proliferative response of lymphocytes to Con A and PHA assessed in allogeneic and autologous serum also seemed to be a useful prognostic parameter. The survival was significantly longer in the group of patients with a normal lymphocyte reactivity to those mitogens than in the non-reactive group.
A rotavirus epidemic took place at the above mentioned department (8. V 1987 until 19. VI 1987). During that period, 36 newborn infants were treated for rotaviral symptoms and they all had their stools checked for rotaviruses or their antigen. Rotaviruses were found by 17 patients (47.2%). As a lab method we used immunoelectrophoresis. 20 patient of the overall number of 36 were boys and 16 were girls. Stool samples showed rotaviruses in 9 boys (45%) and 8 girls (50%). The age of patients was 3 to 34 days. After 1-14 days all children were well.
IgM rheumatoid factor was detected, beside ELISA test, by Waaler-Rose, Latex agglutination and indirect immunofluorescent test. 107 patients hospitalized in the Clinic for heart diseases and rheumatism, as well as 50 healthy subjects were examined. In the first group were 50 patients with RA, 30 patients with other rheumatic diseases and 27 with nonrheumatic diseases. According to our results there was no significant difference between sensitivity of ELISA test and other laboratory tests used. ELISA test was positive in 94% of cases of RA, 20% in other rheumatic diseases and only in one case (3,7%) of a nonrheumatic disease. Compared with the control group in which there was no specific reaction, Waaler-Rose and immunofluorescent testing showed a nonspecific reaction in 2% and Latex test in 4% of all cases. Although ELISA test was not significantly sensitive as compared with other laboratory methods, according to our results, it has high reproducibility, specificity and precision (it is measured in international units/mL serum), and it allows following of the concentration of rheumatoid factor. Besides, ELISA test can be done on 100 specimen of blood within 6 hours and the results are known the same day.
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