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M Shalaby

Publications and source records attributed to M Shalaby.

7 recordsLinked to original sources
PubMed2006

Mainz II and double folded rectosigmoid pouches. Experience with 95 patients.

OBJECTIVES: We report a clinical case series for construction of Mainz II or double folded rectosigmoid pouch with suitable antireflux uretero-intestinal anastomosis. MATERIALS AND METHODS: Ninety-five patients with invasive bladder carcinoma were treated by radical cystectomy and supravesical urinary shunt in form of either Mainz II {56 (58.9%)} or double folded {39 (41.1%)} rectosigmoid pouch. Antireflux techniques for uretero-intestinal anastomosis were subserosal extramural and submucosal tunnels for 122/190 (64.2%) dilated and 68/190 (45.8%) normal caliber ureters. All patients were kept on prophylactic alkalization. Evaluation included clinical, radiological, laboratory, and urodynamic evaluations. Mean follow-up was 40 months. RESULTS: Early postoperative complications were reported in seven (7.4%) cases that were treated conservatively. All patients were continent day and night. Reflux was reported in 2/122 (1.6%) renal units (RU) with dilated ureters and in 1/68 (1.5%) RU with normal caliber ureter, that was managed conservatively. Stenosis at uretero-intestinal anastomosis was reported in 10 (5.3%) RU. Laboratory investigations were within normal. Pouchometry results were comparable in both Mainz II and double folded rectosigmoid pouches. Both were low-pressure good capacity reservoirs. CONCLUSIONS: Mainz II pouch is indicated in cases of normal caliber, unilateral dilated, and some cases of bilateral dilated ureters, while double folded rectosigmoid pouch is optional in case of bilateral dilated ureters. Both have comparable low-pressure urodynamic features.

Adult↗
PubMed1998

Simple assay for detection of circulating antigens in children infected with schistosomiasis.

The ability of monoclonal based dot-ELISA and a previously described solid-phase ELISA were directly compared to detect circulating schistosomal antigens in sera from 50 Egyptian individuals with parasitologically proven schistosomiasis. The mAb employed, 128C3/3/21, recognized a repeating carbohydrate epitope expressed at all stages of the parasite development. The same mAb and patient serum samples were used i both tests, 17 samples from age-matched individuals infected with other parasites but not with Schistosoma were also tested. In the dot-ELISA, 44 serum samples (88%) were found to contain parasite antigens when screen at a dilution of 1;24, 43 serum samples (86%) were positive in the solid-phase ELISA at 1:8 dilution and only 37 (74%) samples were positive at 1:24 dilution. The specificity of the dot-ELISA was 93% as compared to > 99% for the solid-phase ELISA. The detection limit of dot-ELISA was 0.01 ng/ml, whereas only > 1 ng/ml could be detected by the solid-phase ELISA. As dot-ELISA does not require radioactivity or sophisticated equipment, so it is practically well suited for use in endemic areas in developing countries.

Animals↗
PubMed1996

Topical treatment of erectile dysfunction: randomised double blind placebo controlled trial of cream containing aminophylline, isosorbide dinitrate, and co-dergocrine mesylate.

OBJECTIVE: To examine the effectiveness in treating impotence to topically applied cream containing three vasodilators--aminophylline, isosorbide dinitrate, and co-dergocrine mesylate--which act by different mechanisms. DESIGN: Randomised double blinded placebo controlled crossover trial over two weeks. SUBJECTS: 36 men with erectile dysfunction randomly allocated to two equal groups. INTERVENTIONS: Active cream containing aminophylline 3%, isosorbide dinitrate 0.25%, and co-dergocrine mesylate 0.05% for one week and placebo for another. MAIN OUTCOME MEASURES: Patients' reported experience of penile responses and side effects of treatment in questionnaires. Penile tumescence and arterial flow in the laboratory. RESULTS: 21 patients reported full erection and satisfactory intercourse with the active cream. Three men reported full erection and satisfactory intercourse with either cream. The active cream was more effective in psychogenic than organic impotence (eight out of nine men with psychogenic impotence achieved a full erection upsilon four out of eight with neurogenic impotence and two out of seven with arterial insufficiency). No major side effects were reported. In the laboratory the active cream increased penile arterial flow (0.19 (SD 0.08) m/s upsilon 0.02 (0.15) m/s with placebo) and induced tumescence in 24 patients. CONCLUSIONS: Topical treatment with a cream containing three different vasodilators might be considered before intracavernous injection of vasoactive agents, particularly in psychogenic impotence.

Administration, Topical↗
PubMed1996

Comparison of polymerase chain reaction and monoclonal antibodies for G-typing of group A bovine rotavirus directly from fecal material.

A reverse transcriptase and polymerase chain reaction (RT-PCR)-based assay for G-typing of bovine rotaviruses (BRV) was compared with a monoclonal antibody-based immunoassay (MAbs-ELISA) in the characterization of BRV field strains obtained from calves in different regions of Quebec between 1992 and 1994. The strains were analysed for two G types (G6 and G10) which are the most predominate BRV field strains. Fecal samples positive for BRV by polyacrylamide gel electrophoresis (n = 74) were typed by both methods revealing 77% correlation. RT-PCR detected 10 more G6 and 2 more G10 serotypes than MAbs-ELISA. Nine of the 12 discrepant samples could be cultivated and were confirmed as G6 (8) or G10 (1) by both methods. RT-PCR was able to efficiently detect artificial mixes of G6 and G10 and detected two mixed field infections. Four additional infections considered as mixed by MAbs-ELISA and as only G6 by RT-PCR were possibly MAbs-ELISA cross-reactions. RT-PCR provided a very sensitive method for typing BRV field isolates.

Animals↗
PubMed1991

Techniques in endoscopic lithotripsy using pulsed dye laser.

The pulsed dye laser represents a new tool in the treatment of ureteral calculi. Laser energy channeled through a delicate optical fiber is used to disimpact and fragment calculi. Standard ureteroscopic instruments including graspers, baskets and dilatation balloons can be used with the laser system. Interchangeable optical fibers ranging from 200 to 400 micrometers deliver up to 120 mJ of energy to the stone's surface. For two weeks in 1989 an endourology clinic was held in upper Egypt. Eighty patients ranging in age from nine years to sixty-seven years old were evaluated and treated endoscopically. Endoscopes ranging from 6.9F to 12.5F were used to deliver the optical fiber. All stones visualized endoscopically were fragmented. Greater than 60 percent of the stones fragmented were composed of pure calcium oxalate monohydrate. Schistosoma hematobium was endemic among our study group. Bilharzial strictures of the distal ureter were noted in 30 percent of these patients. Treatment of these strictures using both balloon dilatation and graduated Teflon dilators is reviewed. Techniques in treating different types of ureteral calculi were explored. Large calcium oxalate dihydrate stones were treated most efficiently with the 3-point fragmentation technique. The shear off-center technique was used for the calcium oxalate monohydrate calculi. Variations in total energy delivered and frequency of pulsation allowed for prompt stone disimpaction as well as prevention of retrograde fragment migration. Concurrent use of stone baskets and graspers with the pulsed dye laser was explored.

Adolescent↗
PubMedDate not supplied

Patellar tendinitis: the significance of magnetic resonance imaging findings.

We evaluated the significance of magnetic resonance imaging findings in patients with patellar tendinitis. Midline sagittal magnetic resonance images were taken of 12 knees from 10 patients and of 17 knees from 15 age- and activity-matched subjects who underwent imaging for reasons other than patellar tendinitis. Of the 12 magnetic resonance imaging scans of knees with clinical patellar tendinitis, 3 (25%) exhibited no defect and only 7 (58%) had unequivocal intratendinous lesions. Among the 17 scans of subjects without clinical patellar tendinitis, 5 (34%) showed no defect and 4 (24%) had unequivocal intratendinous lesions. Proximal tendon width was significantly larger for the tendinitis patient group (5.0 +/- 1.7 mm versus 3.9 +/- 1.0 mm), although considerable overlap was present. All subjects with unequivocal intratendinous signal changes had a significantly longer nonarticular inferior patellar pole and were significantly older (38.1 years versus 26.8 years). Only Blazina stage III lesions were associated with abnormal findings on magnetic resonance imaging. As a whole, the sensitivity and specificity of magnetic resonance imaging was 75% and 29%, respectively. In younger patients with relatively mild symptoms, magnetic resonance imaging did not show significant changes; in older, active patients changes may be present in asymptomatic knees.

Adult↗