Biomedical subjects
M Shamma
Publications and source records attributed to M Shamma.
Chemistry of 8-chloroberberine.
8-Chloroberberine (V), obtained by treatment of oxyberberine (I) with phosphorus oxychloride, is a reactive intermediate. Treatment with ammonia, methylamine, n-propylamine, aniline, and p-toluidine furnished the 8-berberinylidene derivatives IV and VII-X. Reaction of V with malononitrile, ethyl acetoacetate, and ethyl malonate anions yielded the 8-berberinylidene derivatives XII-XIV. Acid hydrolysis of XIV gave 8-berberinylacetic acid (XV) whose reduction provided 8-canadinylacetic acid (XVI). Grignard reagents react readily with V. Methylmagnesium iodide, ethylmagnesium iodide, and benzylmagnesium iodide led to 8,8-dimethyldihydroberberine (XVII), 8,8-diethyldihydroberberine (XIX), and the benzyl derivative XX, respectively. Sodium borohydride reduction of XX gave rise to 8-benzylcanadine (XXI).
The conversion of berberine into (+/-)-alpha- and (+/-)-beta-hydrastine.
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Pakistanine and pakistanamine, two new dimeric isoquinoline alkaloids.
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Pakistanine and pakistanamine, two novel dimeric isoquinoline alkaloids.
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A new benzylisoquinoline alkaloid: N-methylpalaudinium chloride.
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Cardiovascular effects of veronamine.
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The ultraviolet spectra of phenolic aporphines in basic solution.
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The relationship between the ring D-substituents and the absolute configuration for the aporphine alkaloids.
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(+)-Homoberbines, a new class of heterocyclic compounds.
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A numbering system for camptothecin based on its biogenesis.
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Thalictrum alkaloids. V. Isolation.
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The synthesis of (+)-mesembrine.
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Alkaloids from Vinca herbacea W.K. X. The structures and stereochemistry of majdine and isomajdine.
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Greenheart alkaloids. 3. Sepeerine (ocoteamine) and demerarine.
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The structures and stereochemistry of majdine and isomaydine.
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