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Biomedical subjects

M Shea

Publications and source records attributed to M Shea.

At least 55 records · Page 3Linked to original sources
PubMed1983

Early vitrectomy in proliferative diabetic retinopathy.

Pars plana vitrectomy was carried out in 140 patients with useful to excellent visual acuity associated with elevated proliferative diabetic retinopathy. A substantial reduction in the incidence of traction retinal detachment occurred and a significant improvement in visual prognosis was achieved.

Diabetic Retinopathy↗
PubMed1982

"Early" vitrectomy for vasoproliferative retinopathy in patients with insulin-dependent diabetes mellitus.

Early vitrectomy was carried out in 22 eyes with proliferative diabetic retinopathy and evidence of partial vitreous detachment in 17 patients with insulin-dependent diabetes. All the eyes had undergone panretinal laser photocoagulation, and all had a visual acuity of 6/12 or better, but 13 had had a vitreous hemorrhage. After a mean follow-up period of 29 months 19 of the eyes had retained the same visual acuity, 18 had been free of renewed vitreous hemorrhage for 6 months, there had been no macular retinal detachments and all the anterior segments were normal. The three instances of persistent visual loss were due to recurrent vitreous hemorrhage.

Adult↗
PubMed1982

Management of posterior-segment foreign bodies.

Of 28 patients with a foreign body in the posterior segment, 24 were managed primarily and 4 had been referred for treatment of associated injuries or complications after extraction. There were 19 magnetic and 9 nonmagnetic (including 6 copper-containing) foreign bodies. Preoperative localization was achieved mainly by visual and radiologic (Sweet's) methods, supplemented by computer-assisted tomography and ultrasonography. The magnetic foreign bodies were extracted through the pars plana or sclera. The nonmagnetic foreign bodies were extracted mainly by a two-instrument vitrectomy technique through the pars plana. Secondary procedures included vitrectomy, lentectomy, scleral buckling and dissection of preretinal membranes. In a follow-up period ranging from 1 to 53 (average 14) months the overall salvage rate (final visual acuity 6/60 [20/200] or better) was 46%. Four eyes were enucleated.

Eye Foreign Bodies↗
PubMed1981

Ciliary body reattachment in ocular hypotony.

Ocular hypotony associated with detachment of the ciliary body without evident cyclodialysis has been corrected by reattachment of the ciliary body to the sclera. This was achieved by suturing the ciliary body to sclera under microscopic control. It would seem that prolonged hypotony of this type can be cured by this method.

Adult↗
PubMed1980

The surgical management of macular pucker in rhegmatogenous retinal detachment.

Fourteen patients underwent surgery for macular pucker. The maximal follow-up is 26 months, the minimum is 3 months, and the average is 10 months. The essential feature of the operation is mechanical separation of the posterior cortical vitreous from the retinal surface. A fine wrinkling retinopathy usually remains. Visual recovery, although usually incomplete, is significant and has been maintained throughout the entire period of observation.

Fundus Oculi↗
PubMed1980

Phasic changes in bone CO2 fractions, calcium, and phosphorus during chronic hypercapnia.

The bone CO2 buffering system and bone calcium and phosphorus were studied in guinea pigs exposed to 1% CO2 for periods up to 8 wk and killed at weekly intervals together with control animals of the same age. Measurements were made of arterial CO2 tension, pH, standard bicarbonate, and bone Ca and P. Heat-stabile bone CO2 (carbonate) was determined as dry bone CO2 and heat-labile bone CO2 (bicarbonate) as delta wet-dry bone CO2. During the first 3-4 wk of exposure to 1% CO2, a systemic acidosis was found as indicated in a lowered pH, increased arterial CO2 tension, and decreased standard bicarbonate. The acidosis subsided during the last 4 wk of exposure. Phasic changes in bone bicarbonate were observed as shown in immediate rise lasting for 2 wk followed by a 2-wk decline and second rise after 6 and 8 wk. Bone carbonate exhibited the opposite change during the first 4 wk and thereafter remained stable at an elevated level. Bone Ca and P fell in association with increasing bone bicarbonate and rose with increasing bone carbonate.

Acid-Base Imbalance↗
PubMed1980

Pars plasma vitrectomy in the management of the Irvine-Gass syndrome.

Twelve eyes of 10 patients with type I Irvine-Gass syndrome underwent pars plana vitrectomy after cystoid macular edema had been present a mean of 13 months and showed no evidence of resolving spontaneously or, in some cases, of responding to laser photocoagulation or steroid therapy. The disorder appears to resolve spontaneously in an average of 16 months. Following vitrectomy the edema resolved clinically in 10 of the 12 eyes, in an average of 3.7 months, and the visual acuity improved significantly in 8 of the 12 eyes--in five instances from legal blindness to 20/50 or better. The results suggest that pars plana vitrectomy is of value in the treatment of this disorder.

Adult↗
PubMed1979

The surgical management of macular pucker.

Contractions of collagenous membranes in the posterior cortical vitreous may produce macular pucker and loss of central vision. It is possible to separate these membranes from the retina, and if one succeeds in doing so there is reasonable improvement in central visison. Between December 1976 and September 1978, six patients with macular pucker were operated upon. The clinical details and results are described. The technique used was that of Machemer with the modifications demanded by use of the Klöti vitreous stipper. Several different instruments were used for dissection, the most useful being the joint knife used in stapedectomy.

Cataract↗
PubMed1977

Pars plana vitrectomy.

We describe our first 127 vitrectomies through the pars plana performed on 120 eyes for a variety of indications. The success rate in anterior segment disorders was 45% and in those of the posterior segment 34%. While in some cases the results were encouraging, in others they were disastrous. Some 12 eyes (10%) went on to lose perception of light.

Adolescent↗
PubMed1977

Vitrectomy in retinal detachment surgery.

Pars plana vitrectomy has provided an approach to those situations in which treatment of a retinal detachment becomes impossible due to vitreous pathology. The records of the first 207 pars plana vitrectomies performed by one of us (M.S.) were reviewed and attention was focused on the combined vitrectomy-scleral buckle procedures, particularly with regard to anatomical reattachment and visual improvement. This group was then divided into those in which a one-handed technique was used (29 procedures on twenty-eight eyes, involving 27 patients) and those in which a two-handed technique was used (22 procedures on twenty-two eyes of twenty-two patients). A combined vitrectomy scleral buckle approach has succeeded in reattaching the retina in a number of cases and provided a number of patients with worthwhile visual improvement.

Aphakia, Postcataract↗
PubMed1976

Fetal antigens on the surface of human lymphoid cells.

Human B-lymphoblastoid cells established in long-term culture from healthy adults carry surface components that are normally found in human fetal tissues at about 10 wk of age. These antigens are strongly expressed on neoplastic B lymphocytes but not on thymocytes or a cultured T-cell line. They are carried by a small subpopulation of normal adult peripheral blood lymphocytes as well.

Antigens↗
PubMed1976

Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis.

Cerebrospinal fluid T and B lymphocyte populations were identified in 21 patients with relapsing and 10 patients with stable multiple sclerosis. The results indicate that the percentage of T cell is largest in the acute stage of a relapse (65 percent) and diminishes by the second week (41 percent). Conversely, the stable patients had a lower percentage of T cells (30 percent) and a relatively high percentage of nonreacting cells (66 percent). The proportion of T cells in the cerebrospinal fluid varies directly with the clinical activity of the disorder, further implicating cellular immune mechanisms in the pathogenesis of multiple sclerosis.

Adult↗
PubMed1975

Penetration and survival of mesocercariae (Alaria spp.) in the mammalian eye.

A Canadian woman presented with a motile, intra-retinal worm, which by appearance and movement was strikingly similar to the mesocercaria of Alaria sp., a trematode from frogs. Using these mesocercariae and rabbits this study set out to establish 1) whether these mesocercariae can penetrate the cornea, 2) how long they might survive within the eye, and 3) what reaction is produced. It was found that some penetrated the cornea readily and, after injection, were capable of prolonged survival within the eye. Little overt reaction was produced though histologically the expected chronic inflammatory reaction with eosinophils occurred.

Animals↗