Biomedical subjects

M Sheikh

Publications and source records attributed to M Sheikh.

4 recordsLinked to original sources

PubMed1987

Hybrid molecules containing the A-domain of insulin-like growth factor-I and the B-chain of insulin have increased mitogenic activity relative to insulin.

Two synthetic insulin-like compounds consisting of the B-chain of insulin linked via disulfide bonds to A chains corresponding to the A-domain or the A- and D-domains of insulin-like growth factor I (IGF-I) have been evaluated for mitogenic activity and for binding to IGF receptors and IGF carrier proteins. Both compounds are 3- to 5-fold more potent mitogens than insulin, and have a comparably increased affinity for the type I IGF receptor that mediates these mitogenic effects in chick embryo fibroblasts. Neither compound interacts with IGF carrier proteins. These results indicate that the A-domain of IGF-I is importantly involved in its growth-promoting properties.

Animals↗

PubMed1977

Echocardiographic diagnosis of supravalvular aortic stenosis.

The echocardiographic features of supravalvular aortic stenosis seen in a patient with valvular aortic and multiple pulmonary branch stenosis are described. Since patterns of valvular, discrete subvalvular, and supravalvular aortic stenosis can be recognized by echocardiography, it is now possible to screen close relatives of patients having supravalvular aortic stenosis and pulmonary branch stenosis by this non-invasive technic.

Adolescent↗

PubMed1976

Long-stay patients with long-stay drugs. A case review; a cause for concern.

The psychotropic medication of 200 long-stay psychiatric patients was reviewed by the consutant in charge of the ward, the ward doctor, and the ward sister. Those patients in whom medication was altered or stopped were reassessed by the same team after 6 months. About half the patients on medication had been receiving unnecessary or excessive medication.

Evaluation Studies as Topic↗

PubMed1976

[Herpes gestationis. Immunopathologic studies in mother and child].

Herpes gestationis is a nosologically undefined uncommon bullous disease in pregnancy. In a patient with herpes gestationis C3, C5 und C9 deposits could be demonstrated by immunohistological methods at the epidermal basement membrane (BM). Deposits of immunoglobulins, properdin and C3PA were absent. Autoantibodies against BM were found in the serum of the mother by using rabbit oesophagus but not with normal human skin as antigen. In the sera of mother and child a factor could be demonstrated which in vitro leads to complement fixation in human epidermal BM. Immunopathological findings may speak in favor of a nosological entity of herpes gestationis with respect to dermatitis herpetiformis and bullous pemphigoid.

Adult↗