PubMed Health⌕ Search

Biomedical subjects

M Sher

Publications and source records attributed to M Sher.

43 records · Page 3Linked to original sources
PubMed1981

Antibody-induced degradation of acetylcholine receptor in myasthenia gravis: clinical correlates and pathogenetic significance.

Sera of myasthenic patients containing anti-AChR antibodies increase the rate of degradation of mammalian AChR. This phenomenon, antigenic modulation (AMd), was tested on AChR of rat myotubes in serum from 48 myasthenic patients. Sixty-six percent of the sera increased AChR degradation. AMd activity was higher in more severely affected patients, paralleled clinical evolution in individual patients, and was related to AChR-antibody titer. Steroid treatment and thymectomy did not affect AMd activity. Patients who had a thymoma always had greater AMd activity.

Adolescent↗
PubMed1981

Acute lymphoblastic leukemia in an adult patient.

A case of acute lymphoblastic leukemia in an adult patient has been presented. Acute lymphoblastic leukemia is a neoplastic process in which the leukocyte precursors have been transformed and no longer respond to the forces that normally regulate their proliferation and maturation. The symptomatology, diagnostic procedures, and treatment modality have been discussed. Unfortunately, although complete remission was obtained for two years, the patient developed recurrent acute lymphoblastic leukemia and subsequently died from a massive, uncontrollable infection.

Adult↗
PubMed1977

Pulmonary vascular disease in complete atrioventricular canal defect.

The incidence and time of occurrence of pulmonary vascular disease were studied in 67 children with the complete form of atrioventricular (A-V) canal defect. Advanced pulmonary vascular disease begins to develop during the first year of life, with intimal fibrosis (grade 3 cahnges) noted between age 6 months to 1 year. Vascular dilatation with plexiform lesions (grade 4 changes) can be found by age 1 year. These changes can be found in some patients in spite of hemodynamic findings usually considered to indicate lesser degrees of vascular disease. After age 2 years advanced pulmonary vascular disease is commonly found and may persist after surgical correction of the defects. A similar rapid progression of pulmonary vascular disease was noted in 40 children who had a large ventricular septal defect without A-V canal in whom systemic pressure was transmitted directly to the pulmonary vascular bed. Thirty-six of the 67 children had trisomy-21. No difference was noted in the speed of progression of pulmonary vascular disease between these children and those without trisomy 21. Palliative or corrective surgery should be performed in these patients by age 1 year to prevent development of advanced pulmonary vascular disease.

Age Factors↗
PubMed1976

Social work and general practice. A report of a three-year attachment.

Much has been written about social worker/general-practitioner collaboration, particularly about conflict of roles, differing functions, avenues of accountability, and problems of distributing scarce resources.We suggest that if the two professions are to work more comfortably together, then it is imperative that both also share the despair, hopelessness, anxiety, and anger that are the occupational hazards of each. We suggest ways in which doctors and social workers can look at the pain their patients are suffering to the benefit of the patient and their own working relationship.

Family Practice↗