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Biomedical subjects

M Sherry

Publications and source records attributed to M Sherry.

7 recordsLinked to original sources
PubMed1992

Treatment of Paget's disease by weekly infusions of 3-aminohydroxypropylidene-1,1-bisphosphonate (APD).

Thirty patients with symptomatic Paget's disease of bone were treated with weekly infusions of 30 mg APD for 6 weeks and followed for up to 3 years (mean 2 years). Bone pain diminished or disappeared in 83%. Six months following treatment the serum alkaline phosphatase (sAP) had normalized in 53% and had fallen by an average of 68% in the remainder. The average fall in sAP was 65% at 6 months, 59% at 1 year and 51% at 2 years. Urine hydroxyproline/creatinine ratios (OHp/Cr) fell by an average of 72% over the 6 weeks of treatment whilst serum bone gla protein (BGP) showed no significant change. However, there was a significant fall in the mean BGP of 25% by 6 months following treatment. Radionuclide bone scan abnormalities improved in all patients and showed complete resolution in two. The same regimen was used to retreat eight patients with a persistence or recurrence of symptoms after 1 year. At 6 months following retreatment the sAP had fallen to normal in four and in the remainder by an average of 39%. Two patients had a third course after a further year and by 6 months the sAP had fallen by an average of 50%. Normalization of sAP occurred in 86% of patients with a pretreatment sAP less than 900 iu/l (normal less than 300) and 89% of patients with a sAP less than 600 iu/l immediately following the course of treatment. Therefore, knowledge of the pretreatment and post-treatment sAP should enable prediction of the need for further therapy in most cases. We confirm that APD is an effective and well tolerated treatment for the management of Paget's disease, giving long-term suppression.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1991

Identity processes and perceptions of the life span in chronic mental patients.

This study was an exploratory investigation of identity and life-span perceptions in a sample of thirty-seven chronic mental patients, ranging from twenty-three to sixty-four years of age, using the "life drawing," a projective technique. Age differences were found in the adaptation of identity to the life experiences associated with mental illness. Individuals less than thirty years old were more likely to adopt a "patient identity"; in contrast, the over-forty years-old adapted to their illness through denial. These differences held regardless of psychiatric diagnosis, suggesting a process of identity adaptation more general than is implied in mental disorder diagnostic systems.

Adaptation, Psychological↗
PubMed1985

The reliability of patients in delivering their letter from the hospital accident and emergency department to their general practitioner.

A study over a 2-week period was undertaken to determine what the delivery success rate was for letters given to a patient in the accident and emergency department for delivery to that patient's general practitioner. This was found to be 60% at 2 weeks, rising to 71% at 4 weeks. The only statistically significant factor affecting this success rate was the age of the patient. The importance of the delivery of these letters is emphasized.

Adolescent↗