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Biomedical subjects

M Shifman

Publications and source records attributed to M Shifman.

3 recordsLinked to original sources
PubMed1991

The effect of gangliosides upon recovery of aspartate/glutamatergic synapses in striatum after lesions of the rat sensorimotor cortex.

Changes in neuronal uptake of glutamate/aspartate were studied in the striatum after unilateral destruction of the sensorimotor cortex and injection of GM1 ganglioside. A 75% decrease of uptake of [3H]D-aspartate in the striatum ipsilateral to the cortical lesion was detected at 10 days postlesion compared to the contralateral striatum. We have demonstrated that injection of gangliosides during 10 days returned the uptake of [3H]D-aspartate to control level and compensated loss of the synapses in the striatum after the cortical lesion and thereby can prevent aberrant axonal overgrowth in the contralateral striatum.

Animals↗
PubMed1980

Progressive hepatic injury in prolonged parenteral alimentation.

A morphologic sequence of progressive hepatic injury is demonstrated in an immature infant who received TPN for 148 days. Because immature infants are susceptible to multiple pathophysiologic insults, it is presently impossible to isolate a single etiologic agent responsible for hepatic dysfunction. It is important for physicians caring for immature infants to establish through biochemical and morphologic monitoring that appropriate duration for TPN which is not likely to lead to irreversible hepatic injury.

Humans↗