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Biomedical subjects

M Shimura

Publications and source records attributed to M Shimura.

At least 109 records · Page 6Linked to original sources
PubMed1980

Season of birth in mental disorders in Tokyo, Japan, by year of birth, year of admission and age at admission.

Seasonal distribution of births of schizophrenics and manic-depressives born in Tokyo between the years of 1841 and 1940 and first admitted between 1879 and 1973 was examined by year of birth, year of first admission and age at first admission. In both mental disorders, a fall-excess of births could be seen among those born up to the latter part of the 19th century, after which the distribution changed to show a spring-excess. The distributional pattern seemed to depend upon both year of birth and year of admission, rather than on age at first admission.

Adult↗
PubMed1980

[Secular change in the seasonal distribution of menarche in Tokyo].

Secular change in the seasonal distribution of menarche was studied in Tokyo on 17545 females born during 1881 - 1963. The distribution in those born before 1890 showed peak (March-May) and a wide trough during July-October. Occurrences of menarche came to concentrate in April and August after 1890, and also in January after 1950. The distributional pattern has much changed by the period of birth year.

Female↗
PubMed1979

[Seasonal variation of menarche and month of birth (author's transl)].

Seasonal variations in the occurrence of menarche in 1226 Japanese girls are not uniform, when they were divided into two groups by their season of births. Summer trough (May-July) was inapparent in girls born in summer (May-October), and winter trough (February-March) was less deep in girls born in winter (November-April). No differences were found in fall trough (September-November) between both groups. Girls born in summer (or winter) seem to be resistant to some summer (or winter) factors, which inhibit the occurence of menarche.

Adolescent↗
PubMed1977

Season of birth of schizophrenics in Tokyo, Japan.

The monthly distribution of births of 7,960 schizophrenic patients in Tokyo born during the period of 1841-1950 was studied in comparison with that of a control population in Tokyo. A spring excess of schizophrenic births were found after 1901 as in previous studies in Western countries. Before 1900, however, there was no significant spring excess. The maximum excess of schizophrenic births occurred in May before 1900 and in April after 1901. The possibility of a shift in the seasonality of schizophrenic births was discussed.

Birth Rate↗
PubMedDate not supplied

Molecular genetic analysis of ABCR gene in Japanese dry form age-related macular degeneration.

PURPOSE: To explore whether the mutation in the retina-specific ATP-binding cassette transporter (ABCR) gene, the Stargardt's disease gene, contributes to the prevalence of the dry form of age-related macular degeneration (dry AMD) in Japanese unrelated patients. METHODS: Twenty-five Japanese unrelated patients with dry AMD who were diagnosed by fluorescein angiography and indocyanine green angiography were chosen as the dry AMD group. None of these cases had apparent choroidal neovascularization. To detect the mutations in the ABCR gene, genomic DNA was extracted from leukocytes of peripheral blood, and 26 exons of the ABCR gene were amplified by polymerase chain reaction (PCR). All the PCR products were then directly sequenced. When a mutation was detected, the occurrence of a mutation was compared between these AMD patients and the control group. RESULTS: After direct sequencing, a point mutation in exon 29 was found in one of the 25 dry AMD patients. In addition, a polymorphism in exon 45 was found in two other patients, and three sequence variations in exon 23 were detected in all patients. The incidence in AMD patients in whom a mutation in exon 29 (4%) was detected was less than that in controls (5%). Screening of the intron-exon boundaries also led to the identification of intronic mutation in intron 33. CONCLUSION: In this study we found no relationship between allelic variation in the ABCR gene and the prevalence of dry AMD in Japanese unrelated patients.

ATP-Binding Cassette Transporters↗
PubMedDate not supplied

Changes of recollected menarcheal age and month among women in Tokyo over a period of 90 years.

Data on the recollected age at menarche of 47,881 women born between 1881 and 1970 were examined. The mean menarcheal age had changed from 15.1 years in those born up to 1900 to 12.5 years in those born during the 1960s. The age at menarche differed according to the month of birth, and the pattern of average age distribution by month of birth was not the same when the year of birth was different. Among women born before 1955 the menarcheal age was earlier in those born in the summer. However, among women born after 1955, menarche occurred later when they were born in the summer. The monthly distribution of menarche had also changed during this 90-year period. Two peaks in April and August were prominent among those born up to 1960. A third peak in January became also apparent in those born after 1960.

Adolescent↗
PubMedDate not supplied

Intraocular hemangiopericytoma. A case report.

A 55-year-old man presented with a smoothly elevated solid choroidal mass with choroidal detachment in the temporal region of the left eye. Both fluorescein and indocyanine green angiography suggested a vascularized lesion such as an angioma. However, radiographic examination revealed a solid, circumscribed, dome-shaped mass. During a 3-month observation, the mass gradually enlarged and invaded the iris. The possibility of malignant melanoma could not be ruled out. Due to rapid and continued growth of the tumor, the eye was enucleated. Histopathologic examination revealed proliferation of spindle-shaped cells surrounding reticulin-positive vessels, which is characteristic of hemangiopericytoma. To our knowledge, this is only the fourth reported case of intraocular hemangiopericytoma and the first diagnosed in a male patient.

Choroid Neoplasms↗
PubMedDate not supplied

Accumulation of mutant p53 and hsp72 by heat treatment, and their association in a human glioblastoma cell line.

The cellular content of mutant p53 and hsp72 proteins following gamma-ray irradiation, UV irradiation, and heat treatment was studied in A-7 cells, a human glioblastoma cell line. A-7 was found to contain a mutant p53 gene in which the arginine codon at position 175 was substituted by a histidine codon. Although the p53 gene was mutant, the phenotype of the p53 protein appeared wild-type since the cellular content of the p53 protein was limited under normal culturing conditions. The quantity of mutant p53 and hsp72 proteins in A-7 was increased by heat treatment as well as gamma-ray and UV irradiation. Furthermore, the mutant p53 protein was coimmunoprecipitated with anti-hsp72/hsc73 antibody. Additionally, hsp72 and hsc73 were coimmunoprecipitated with anti-p53 antibody. These results suggest that in A-7, p53 protein accumulation may be caused as a result of response to stressors, such as gamma-ray, UV and heat and that mutant p53 protein and hsp72/hsc73 may manage biological functions cooperatively after gamma-ray, UV and also heat treatments.

Gamma Rays↗
PubMedDate not supplied

Treatment of disseminated intravascular coagulation with gabexate mesilate.

Gabexate mesilate (FOY) was used to treat 215 patients with disseminated intravascular coagulation (DIC) and 146 patients with a predisposition to DIC (pre-DIC). Sixty percent of DIC patients and 48% of pre-DIC patients exhibited pretreatment organ failure, which resolved after FOY treatment in 16% of DIC patients and 17% of pre-DIC patients. Seventy percent of DIC patients and 49% of pre-DIC patients had a pretreatment bleeding tendency that was ameliorated by FOY treatment in 32% of DIC patients and 30% of pre-DIC patients. Comparison of pretreatment and posttreatment hemostatic studies of the DIC patients revealed that platelet count and levels of fibrinogen degradation products (FDP), thrombin-antithrombin-III complex, and FDP-D-dimer decreased significantly; fibrinogen level increased markedly; and prothrombin time was prolonged. DIC scores were significantly lowered in both leukemic and nonleukemic patients from the third day of treatment with FOY. Among leukemic DIC patients, 59% showed complete remission (CR), 21% partial remission (PR), and 7% exacerbation of their condition; 46% of the nonleukemic DIC patients demonstrated CR, 17% PR, and 17% exacerbation. Of the leukemic pre-DIC patients, 59% showed improvement and 7% exacerbation, whereas 55% of the nonleukemic pre-DIC patients showed improvement and 27% exacerbation.

Disseminated Intravascular Coagulation↗