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Biomedical subjects

M Sigmund

Publications and source records attributed to M Sigmund.

44 records · Page 3Linked to original sources
PubMed1991

[Myocarditis caused by Toxoplasma gondii and Aspergillus fumigatus after orthotopic heart transplantation].

This report describes the case of a 56-year-old patient, who died 53 days after orthotopic heart transplantation due to myocarditis caused by infection with Aspergillus fumigatus and Toxoplasma gondii. Aspergillosis was diagnosed by transthoracic needle aspiration of a pulmonary infiltration. Endomyocardial biopsy showed toxoplasma pseudocysts. Autopsy revealed myocardial infection with both infectious agents. Despite specific therapy, myocarditis determined the fatal outcome in this case. The value of invasive techniques for specific diagnosis of infectious diseases in immunocompromised patients is discussed.

Aspergillosis↗
PubMed1991

[Incidence of pathologic ECG findings in survivors of electric accidents].

ECGs of 320 male survivors of electrical accidents were examined. The results were compared with findings in normal populations reported in previous epidemiological studies. 243/320 electrocardiograms (75.9%) were considered to be normal. In 42/320 (13.2%) unspecific electrocardiographic changes were seen, and in 35/320 (10.9%) abnormal ECGs were found. No significant accumulation of ECG changes was observed in comparison to the control groups. Results confirm abnormal ECG-findings to be rare in humans who sustain non-fatal electrical injury. If an ECG is considered to be abnormal, a causal relationship is only probable if findings are documented immediately after injury, and if serial ECT controls demonstrate significant changes in comparison to the initial abnormality.

Adult↗
PubMed1991

["QT" pacemaker in aggregate exchange. Do old electrodes impair functional ability?].

A "QT"-interval driven rate responsive pacemaker can also be implanted on the occasion of pacemaker replacement. To evaluate the electrophysiological properties and limitations of chronic leads, in 30 patients the evoked intracardiac electrogram was recorded via the chronic lead during pacemaker replacement (14 different types, mean interval after implantation 111 (25-171 months). T-wave detectability was evaluated with different pulse amplitudes (2.5 and 5.0 V) and two pacemaker systems (TX 915, Rhythmyx) with different "fast recharge" mechanisms. In particular, the T-wave signal was influenced by capacitor discharge effects. At 2.5 V output T-wave amplitude was greater than or equal to 1.5 mV in all (19) patients, who could be paced at this voltage. However, at 5 V in 9/30 patients T-wave was less than 1 mV and detection was not possible in 6/30 cases. During pacing with the newly developed "QT"-interval driven, rate-responsive pacemaker (Rhythmyx) with two fast recharge pulses, in nine investigated patients the T-wave was markedly better discriminable compared to the TX 915 pacemaker. Accordingly, in 37 patients with implanted "QT"-controlled pacemakers (TX 911): n = 13; TX 915: n = 21; Rhythmyx: n = 3. Indication for pacemaker therapy: high degree AV block: n = 24, sick-sinus syndrome: n = 13) reliable T-wave sensing was possible at 2.5 V/0.2 ms output, whereas at 5 V/2 ms no T-wave sensing could be achieved in 8/37 cases. On the occasion of pacemaker replacement the "QT"-controlled pacemaker can be implanted without intraoperative measurements, whenever a pulse amplitude less than 2.5 V is sufficient for stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)

Electrocardiography↗
PubMed1989

[A heart rate adaptable "physiologic" pacemaker. Is the effort worthwhile?].

The dual-chamber pacemaker provides an approximately physiologic cardiac action in patient with 3rd degree AV-block and preserved sinoatrial function. Newly developed so-called rate-responsive systems are now available. Initial clinical experience has been reported with pacemakers controlled via respiration rate, activity, central venous blood temperature, or intracardially measured QT-interval. The sensitivity and specificity of rate regulation like the effort of implantation and setting is not completely satisfactory and adequate until now. At the present time, such systems are being implanted mainly according to individual indications. Before a general use can be recommended, several problems still remain to be solved, in particular the question as to what therapeutic advantage is to be expected with respect to the underlying disease, arrhythmia and patient group.

Bradycardia↗
PubMed1988

Simple method for rapid and highly sensitive detection of antiviral-antibodies in serum and cerebrospinal fluid of small laboratory animals.

A technique is described for the small-scale determination of antibodies in blood and liquor. Small sample volumes of about 3 microliter blood and 15 microliter liquor are sufficient to detect even low antibody titers against different proteins. Thus, for studying the timecourse of antibody titers, repeated examinations of small laboratory animals are possible. The method includes the highly reproducible separation of the antigens in a 45 X 35 X 0.5 mm polyacrylamide gel (6.5%) using the Phast-system (Pharmacia), followed by electrotransfer and immunostaining. The whole procedure takes less than five hours.

Animals↗
PubMed1983

PEDPLO: a pedigree plot program.

The program PEDPLO supports the graphical presentation of inheritance. The plot produced is a tree ramifying towards the younger generation. There is only little dependence on the special software and hardware of the plot.

Computers↗