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Biomedical subjects

M Silie

Publications and source records attributed to M Silie.

At least 19 recordsLinked to original sources
PubMed1987

Uncorrected pre-ejection period: a simple non-invasive measurement for pharmacodynamic screening of inotropic activity.

Since heart rate (HR) is an important determinant of the duration of systole, systolic time intervals (STI) from 8 healthy subjects were examined after infusion of atropine. As no overall correlation was found between HR and pre-ejection period (PEP), the results confirm the need for individual estimates of the correction of the left ventricular ejection time (LVET) and the total electromechanical systole (OS2). In the same subjects the sensitivity of PEP to minor negative inotropic effects of mexiletine and disopyramide measured at Cmax was confirmed. Thus, in addition to its simplicity and reliability, the sensitivity of the uncorrected PEP should encourage use of this technique as part of any screening system for the early detection of an inotropic effect of new chemical entities.

Adult↗
PubMed1985

[Neurinoma of the posterior cerebral fossa and mitral valve prolapse. Possible association and study of possible peri-operative consequences on rhythm].

27 patients with an acoustic neurinoma were submitted to a complete cardiological survey oriented towards the detection of mitral valve prolapse (2D echo) and ECG signs of a particular risk of arrhythmia (standard ECG and continuous Holter monitoring). 9 of these 27 patients presented MVP, but none of them presented any serious ventricular arrhythmias. The corrected QT interval was significantly longer in patients without MVP. The frequency of the association of MVP and acoustic neurinoma can not be explained simply by the female predominance of the series and its should be interpreted with reservation in the absence of a control series. The absence of pre-operative arrhythmia does not exclude the potentiating role of MVP in the development of certain cases of unexplained post-operative death.

Adult↗
PubMed1981

[Tricuspid valve replacement with aortic valve allograft. Clinical and haemodynamic results more than five years after (author's transl)].

Between 1970 and 1974, twenty-three patients with advanced multivalve lesions underwent tricuspid valve replacement with a human aortic valve allograft (26-28 mm in diameter) mounted on a Shumway ring. The mean follow-up was 76.7 months. Early post-operative mortality was 4.4% and late mortality 17.4%. The actuarial survival rate was 86.6% at 5 years and 74.2% at 8 years. In 1979, 17 out of 18 survivors (one was lost sight of) were reinvestigated by cardiologists. Late functional improvement z found in 82.2% of the cases; two patients failed to improve owing to recurrent mitral stenosis. On clinical examination 12 out of 15 subjects showed no sign of right ventricular failure. In 54% the cases phonocardiography revealed abnormal tricuspid sounds indicating variable and moderate deterioration of the allograft. Haemodynamic studies showed a significant decrease in mean right atrial pressure (p less than 0.001) and mean pulmonary artery pressure (p less than 0.001), and an increase in cardiac index (p less than 0.01). The diastolic gradient through the graft was always inferior to 3 mmHg (mean 1.2 mmHg), with little change on exercise. This was significantly less than the 3.9 mmHg gradient observed with tricuspid valve replacement using Hancok valve. These were the only tricuspid valve replacements performed in our unit in 1970-74. The satisfactory long-term results obtained contrast with the frequent deterioration observed in aortic valve replacements carried out during the same period by the same team, using the same technique

Aortic Valve↗