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Biomedical subjects

M Silva-Hutner

Publications and source records attributed to M Silva-Hutner.

15 recordsLinked to original sources

Disseminated cryptococcosis in an asymptomatic alcoholic man.

Widely disseminated cryptococcosis was found on autopsy in a 50-year-old alcoholic man. The spleen, lungs, CNS, liver, kidney, and lymph nodes were all involved. In his clinical course, the patient showed no signs of immunologic anergy. His terminal hospital course resulted directly from end-stage liver disease and renal failure. The cryptococcal infection was of the nongranulomatous, diffuse type with little or no inflammatory response, which probably explains the lack of symptoms.

Antigens, Fungal↗

Fungal peritonitis and malignancy: report of two patients and review of the literature.

Two patients developed isolated Candida albicans peritonitis in association with intraabdominal malignancy. Although additional factors predisposing to the development of fungal peritonitis were present, we postulate that tumor-related local factors permitted fungi to cross the gut wall and to enter the peritoneum, where the host immune status determined whether the infection spread. These two cases are the sixth and seventh reported cancer patients who developed fungal peritonitis, but the first two who had the fungal infection localized to the peritoneum; and this is the first report known to us specifically associating intraabdominal malignancy and fungal peritonitis. Patients who develop fungal peritonitis may have a primary or metastatic intraabdominal malignancy, and fungi should be considered as a cause of peritonitis in cancer patients.

Abdominal Neoplasms↗

Differences in the growth of Aspergillus fumigatus on cycloheximide media at three temperatures.

Cycloheximide (up to 0.4 g/liter) was significantly more inhibitory to the growth of three isolates of Aspergillus fumigatus at 23 C than at 37 or 45 C. Preincubation of the media for 7 days at 45 C did not alter the inhibitory effect of the cycloheximide at 23 C. Neither mutation nor adaptation in the fungus seems to be the reason for its growth on the antibiotic at the higher temperature. The mechanism for the differences in sensitivity as related to temperature of incubation cannot be explained at this time.

Aspergillus fumigatus↗