The diagnosis and treatment of severe masked depression in schizophrenia is discussed, and the difficulties in management are stressed, with particular reference to drug therapy, E.C.T., and psychotherapy.

Acute Disease↗

PubMed1978

Oxypertine in combination with imipramine: a controlled trial.

A method for the controlled assessment of two agents for possible interaction in the treatment of endogenous depression is described. This consisted of dose-ranging the supplementary agent (oxypertine 30 mg and 60 mg daily or matching placebo) during Week 2 to Week 6 having established all patients on a therapeutic dose of imipramine during Week 1. The reported enhancement of imipramine by oxypertine was not confirmed.

Adult↗

PubMed1975

The Hamilton rating scale. An assessment bases on a dothiepin ("prothiaden") versus imipramine ("Tofranil") clinical trial.

The Hamilton Rating Scale for Depression is in common use, particularly in durg trials. The authors compared this scale with a system of psychiatric assessment and recording designed by M. Sim. They found that there was closer agreement with the full assessment of the Sim method than with the single diagnostic area for depression. This suggests that the Hamilton Scale for depression is more general than specific in its application.

Clinical Trials as Topic↗

PubMed1975

A double-blind controlled therapeutic trial of lorazepam vs medazepam in psychosomatic conditions in general practice.

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Adolescent↗