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Biomedical subjects

M Simo

Publications and source records attributed to M Simo.

At least 19 recordsLinked to original sources
PubMed1993

[Protective effect of Neoton during cardiovascular surgery. Hemodynamic and biochemical aspects].

The authors present the preliminary results of an experimental study where to a group of patients (n = 10) subjected to cardiosurgery, using extracorporeal circulation, to the cardioplegic solution creatine phosphate was added (Neoton of Alfa Schiaparelli Wasserman Co.)--2 g.l-1. The authors investigated haemodynamic and biochemical parameters and compared them on the day of operation with the same parameters assessed in a group of controls operated in the same way but without addition of creatine phosphate to the cardioplegic solution. Apart from insignificant differences in haemodynamic parameters the group of patients given Neoton had a lower malondialdehyde level during the early stage after termination of extracorporeal circulation, spontaneous defibrillation, a lower incidence of dysrhythmias and disorders of the conduction system. It can be assumed that creatine phosphate (Neoton) may be effective in the protection of the myocardium from ischaemia reperfusion damage.

Adult↗
PubMed1989

[Anomalies of venous drainage of the left lung].

The authors present their experiences with diagnosis and surgical treatment of anomalous venous drainage of the left lung into the left innominate vein. The anomaly was found only in four out of 704 patients operated on for atrial septal defect. In three patients in whom leftsided anomalous pulmonary venous drainage was associated with atrial septal defect, the derangement was corrected by using extracorporeal circulation. The patient who had no atrial defect was operated on without extracorporeal circulation on applying leftsided thoracotomy. The mean age of the patients was 26.25 years. After correcting the defect, drainage of the left lung into the left atrium was found satisfactory in all operated patients. Exact assessment of the possibility of an associated intracardiac defect is being emphasized, as it is crucial for selecting the appropriate surgical approach.

Adolescent↗
PubMed1988

New nonsurgical technique for multiple pericardial biopsies.

We report a new, nonsurgical technique for obtaining multiple pericardial biopsies in patients with pericardial effusion. A short catheter is introduced by the Seldinger technique under fluoroscopy through the subxiphoid approach. The pericardial fluid is aspirated and the catheter replaced by an 8F teflon sheath with a curved tip. A bioptome is inserted through the sheath, and air is allowed to enter the pericardium. This method outlines the parietal percardium. The curved sheath directs the bioptome to the left or right wall. Eighteen consecutive patients had an average of eight pieces of pericardium removed. On histological examination, three patients had malignancy. Six had tuberculous granuloma, and mycobacterium tuberculosis was cultured from all six tissue specimens but only once from the fluid. Tissue smears showed acid fast bacilli in four out of six, whereas the fluid was negative in all. The biopsy yielded diagnostic information in nine out of ten patients with a thickened pericardium. There were no complications.

Biopsy↗
PubMed1987

"Pulmonary tongue" a right ventricle phase abnormality in muga studies in patients with pulmonary hypertension.

Pulmonary hypertension (PH) produces strain followed by hypertrophy and later dilatation of the right ventricle (RV) and pulmonary artery. The signs and symptoms are nonspecific. There is a need for a noninvasive sensitive way to diagnose PH. The purpose of this study is to evaluate phase abnormalities in radionuclide MUGA studies of patients with referred diagnosis of PH. In a retrospective analysis of 44 patients who had a radionuclide multigated study (MUGA) and contrast ventriculography (CV), 19 had high mean pulmonary pressure (over 20 mmHg) and a high pulmonary vascular resistance index (over 2.0). In 15 patients, a delayed phase segment in the RV corresponding to the pulmonary infundibulum and pulmonary conus was noted "The Pulmonary Tongue" sign (PT), 12 had PH (True positive) and 3 did not (false positive) on CV. No PT was seen in the remaining 29 patients, only 7 of them had PH (False negative). The sensitivity, specificity and accuracy of the PT sign in detecting PH was 80%, 72% and 77% respectively. The number of patients was too small to calculate the correlation of the grade of PT with the severity of PH. We conclude that "The Pulmonary Tongue" sign on a MUGA study is clinically useful in detecting PH.

Adult↗
PubMed1986

A comparison of two radionuclide ejection-fraction techniques with contrast angiography in ischemic heart disease and valvular heart disease.

First-pass radionuclide angiography (FPRA) in the 30 degree right anterior oblique and equilibrium gated radionuclide angiography (EGNA) in the 45 degree left anterior oblique were used for quantitative measurements of left ventricular ejection fraction (LVEF). Equipment used was a 400T gamma-camera interfaced with a Simis III Informatek computer. The results were compared with contrast angiography (CA). The aim of this study was to determine the sensitivity of both radionuclide techniques. The present data are based on 65 patients in whom CA and EGNA were performed. In 47 patients both FPRA and EGNA were performed. Results suggested that in ischemic heart disease (IHD) and valvular heart disease (VHD) the EGNA technique is well correlated with CA (r = 0.9 and 0.73, respectively). FPRA correlated well only with CA in IHD (r = 0.86), but not in VHD (r = 0.18). This study indicates that both FPRA and EGNA are sensitive, noninvasive techniques for measuring ejection fraction in IHD, while in VHD, EGNA is more sensitive technique than FPRA.

Adolescent↗
PubMed1986

Asymptomatic severe aortic regurgitation in the young. Hemodynamic and angiographic data in 37 patients with echocardiographic correlation.

The aim of this study was to evaluate from hemodynamic and angiocardiographic (ACG) data the extent of left ventricular (LV) systolic dysfunction in a group of predominantly young (mean age 29 years) asymptomatic patients with severe aortic regurgitation (AR). In addition, echocardiography was performed and these data were correlated with ACG data and the value of these parameters in predicting LV dysfunction was tested. Thirty-seven patients were catheterized and 18 demonstrated LV dysfunction with an ejection fraction (EF) of less than 50%. These patients were classified as group A and the remaining 19 patients with EF greater or equal to 50% formed group B. While there was no difference between the 2 groups with regard to age or regurgitant fraction, the end-diastolic pressure was raised (p less than 0.01) and cardiac index depressed (p less than 0.05) significantly in group A. Of the echocardiographic parameters, the end-systolic diameter (ESD) correlated best with the EF (coefficient of correlation = -0.7 and p less than 0.001). In addition, the ESD was significantly higher in group A (p less than 0.001). When an ESD greater than or equal to 48 mm was used as a predictor of an EF less than 50% (group A) the sensitivity was 89% and the specificity 79%. In conclusion, many young asymptomatic patients with severe AR may have severe LV systolic dysfunction and an ESD greater than or equal to 48 mm is a good predictor of such a subgroup.

Adolescent↗
PubMed1986

Coronary artery disease in patients aged 30 and younger.

Twenty-four male patients aged 18-30 (mean = 27.4) years were catheterized either after myocardial infarction (22 patients) or because of angina pectoris (2 patients). In this highly-selected group, 18 of 24 smoked but only 5 had elevated cholesterol levels. Of 14 patients with anterior myocardial infarction (AMI), 7 had a significant left anterior descending obstruction while the other 7 had nonsignificant or no coronary stenosis. In 8 patients with inferior MI (IMI), 4 had significant multivessel disease. Five of 6 patients with multivessel disease smoked while 4 had hypercholesterolemia. Risk factors were absent in 3 of 16 patients with single or no coronary lesions. We conclude that angina pectoris and inferior MI carry high risk of multivessel coronary disease; there is often one or more risk factor in this subgroup. Finally, routine catheterization in young patients with AMI is not warranted.

Adolescent↗
PubMed1985

Tricuspid stenosis and regurgitation in rheumatic heart disease: a prospective cardiac catheterization study in 525 patients.

Cardiac catheterization (CC) was done in 525 symptomatic patients. Tricuspid regurgitation (TR) was graded from right ventricular (RV) angiography (RVA) and compared with RV indicator curves (IC). Tricuspid stenosis (TS) was diagnosed from the mean diastolic gradient (MDG). Organic (O) disease was diagnosed from TS or from thickening of the tricuspid valve (TV) on angiography. TR was found in 137 patients (26%), of whom 46 (33.5%) had additional TS. All of the patients with TS had significant TR. OTR was more frequent (70.4%) and more severe (p less than 0.0001) than functional TR (FTR). There was no difference in pulmonary artery pressure between FTR and OTR except when associated with TS. The TV was explored in 56 patients. A MDG greater than or equal to 2 mm Hg correctly predicted TS in 91% of the patients and right atrial angiography in 100% of the patients. Organic thickening of the TV was predicted in 84%.

Adult↗
PubMed1985

Clinical experience with stress and delayed thallium-201 quantitative segmental washout curves (QSWC).

Stress thallium-201 myocardial studies in 29 patients with chest pain were performed. The findings of digital display (DD) and quantitative segmental washout curves (QSWC) were compared independently and jointly with coronary angiography. It was found that QSWC is more sensitive (71%) than DD (55%) but is less specific (58%) than DD (98%). Taking both approaches together the sensitivity rises to 94% and the specificity falls to to 61%. Using both DD and QSWC for interpretation of thallium studies improves the agreement ratio with coronary angiography by 25% more than when using DD only.

Adult↗