Biomedical subjects
Publications and source records attributed to M Sindjić.
A boy who developed haemolytic-uraemic syndrome (HUS) at 8 years 6 months of age had four further episodes of the disease during the next 3 years. No renal abnormalities were detected between the attacks nor in the 2.5 years after the last recurrence. Reduced levels of serum complement were found during four of the episodes and in two intervening periods.
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Explore the source record for details and available documents.
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Clinical and hystological features of IgA nephropathy were evaluated in 17 children (age range 6 to 14 years). Hematuria was present in all patients (macroscopic hematuria in 10 patients, microscopic hematuria in 7). Mild to moderate proteinuria was present in 10, nephrotic syndrome in two cases. The majority of renal biopsy showed normal picture of mild mesangial proliferation, with crescents in only one patient. Transient impairment of renal function developed in two patients. One of patients progressed to chronic renal failure. Four patients were treated (two with persistent proteinuria, one with nephrotic syndrome, one with nephritic syndrome). Corticosteroid treatment resulted in aggravation of proteinuria in two patients with persistent proteinuria. Patient with nephrotic syndrome demonstrated only diminution of proteinuria during different treatments: corticosteroids, ciclophosphamid and Ciclosporin A. Ciclophosphamid was beneficial in patient with nephritic syndrome.
The acute intoxication (by intraperitoneal way) and chronic intoxication (by inhalation, during one year) were carried out with pure copper. On the basis of experimental studies, it was established that the kidney was a critical organ in copper intoxication. On all rats acutely intoxicated damages of the function (similar to Fanconi's syndrome in Wilson's disease), diffuse pathologic lesions and presence of fine copper particles in protoplasm of proximal tubule epithelial cells, were found. By chronic intoxication it was proved that the organism could be loaded with copper through inhalation of copper particles. In chronic intoxication damages of renal functions were insignificant, but very heavy pathohistologic lesions were only focal and they influenced glomerules, proximal tubules, initial parts of Henle's loop and interstice. Copper was found in the form of strip-like deposits in glomerules and proximal tubule basal membrane, then in the form of fine and coarse granules in protoplasm of proximal tubule epithelial cells.