Biomedical subjects

M Skoczeń

Publications and source records attributed to M Skoczeń.

11 recordsLinked to original sources

PubMed1990

Ventricular arrhythmias and echocardiographic parameters of the left ventricular morphology in elderly patients with arterial hypertension.

An analysis of cardiac arrhythmias in relation to left ventricular morphology and function was performed in 68 hypertensive patients 60 to 83 years of age. The study comprised Holter monitoring and echocardiography. Our results suggest that in elderly patients with primary arterial hypertension a correlation exists between left ventricular mass and the incidence of ventricular arrhythmias but not between left ventricular mass and supraventricular arrhythmias.

Aged↗

PubMed1989

[Enalapril in the treatment of primary arterial hypertension].

Enalapril (20 mg daily) was used in the treatment of primary arterial hypertension in 28 patients with the WHO class I and II and diastolic blood pressure ranging from 105 to 120 mm Hg. Hypotensive effect after an initial dose of enalapril occurred in 12 patients (42.8%) in whom a decrease in blood pressure at 1 hr exceeded 10% of the basal value (from means = 169.9/109.1 to 146.7/97.9 mmHg). At 6 weeks positive hypotensive effect was found in 46% of patients. A combination of enalapril with hydrochlorothiazide (25 mg daily) in patients without normalization of the blood pressure level increased the number of the favourably treated to 64%. Of 12 patients with positive effects after the first dose of enalapril only seven patients profited from chronic enalapril monotherapy. In chronic treatment enalapril seemed to be well tolerated and side effects were only sporadic.

Adult↗

PubMed1989

[Nifedipine level in the blood and its immediate hypotensive effect after its sublingual administration to aged patients].

In 28 aged patients (means = 73.1 years) with arterial hypertension nifedipine has been administered sublingually in a single dose of 20 mg and the hypotensive effect of that drug under the control of its concentration in the blood serum was evaluated. The nifedipine concentration was determined by the use of gas chromatography with electron capture detector. The mean drug concentration increased from 38.1 ng/ml to 82.3 ng/l during the 2nd hour of observation. After 3 hours the lowering of the nifedipine concentration and the decrease of its hypotensive effect was observed. After 15 min from the drug application the systolic pressure lowered by the average 22.1 mmHg whereas the diastolic pressure was 7.0 mmHg lower. The most significant pressure decrease (mean of systolic pressure 52.7 mmHg) 7.03 kPa and that of diastolic pressure 23.2 mmHg (3.1 kPa) occurred after 2 and 1.5 hours. The decrease of pressures after nifedipine correlated with the start-point value of systolic pressure. The frequency of the heart action in the whole group did not altered significantly, however, in individual cases both the acceleration of that action (34 per min) or acceleration (42 systoles per min) was noted. Slight typical side-effects were noted in 5 treated patients. A single-dose sublingual 20 mg nifedipine (Cordafen--Polfa) administration enabled in all the subjects the obtaining of therapeutic drug level in the blood and in the aged patients with hypertension may be regarded as efficacious antihypertensive treatment.

Administration, Sublingual↗

PubMed1988