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Biomedical subjects

M Slattery

Publications and source records attributed to M Slattery.

30 records · Page 2Linked to original sources
PubMed1986

The occupational risks of alcoholism.

The occupations of 6,596 psychiatric admissions with alcoholism were analyzed and their admission rates compared with occupational death rates due to cirrhosis of the liver. Two thirds of occupations with high admission rates had correspondingly high cirrhosis death rates but a dozen occupations had low admission rates and high liver cirrhosis death rates, suggesting a degree of heavy drinking which is not treated. Low-risk occupations are identified and their characteristics discussed.

Adolescent↗
PubMed1978

Clinical application of human-placental-lactogen values in late pregnancy.

Human-placental-lactogen (H.P.L.) levels were measured in the blood of 1000 women in the third trimester of pregnancy to see how measurement of H.P.L. could help in the management of an obstetric population in Britain. It was found that in the 93% of the population with a mean H.P.L. level of 4.3 mg/l or above, only 1.1% would have a poor pregnancy and 4.8% a compromised pregnancy. Of the 7% with levels below 4.3 mg/l, 57% woul have a normal outcome and 43% a poor or indifferent outcome. The false-positive rate was considerable, but the results of the study indicate nevertheless that H.P.L. levels are useful in predicting the outcome of pregnancy and that their measurement should be included as part of routine screening in the third trimester.

Birth Weight↗
PubMed1977

Twice weekly prophylactic therapy in haemophilia A.

Factor VIII-containing materials were administered to four severely affected haemophiliacs twice weekly in doses calculated to raise the factor VIII level to either 15% or 30% of average normal. The pooled results from those patients with statistically similar baseline bleeding frequencies showed a significant reduction in bleeding frequency on both doses in the first 48 hours. The 30% dose produced a more significant reduction than the 15% dose in the first 24 hours, but there was no significant difference between the two doses in the second 24 hours. It appears that to reduce the bleeding frequency of severely affected haemophiliacs by 60% would require a two-and-a-half-fold increase in therapeutic materials. A 90% reduction would need nine times the amount of material currently in use.

Child↗
PubMed1976

Prophylaxis in haemophilia: a double-blind controlled trial.

A double-blind controlled trial of prophylactic factor VIII therapy has been carried out on nine severe haemophiliacs at the Lord Mayor Treloar College. Infusions were given once weekly and calculated to give a post-infusion plasma concentration of at least 0.25 I.U./ml of factor VIII. This regime reduced the overall bleeding frequency by 15%. The bleeding frequency in the first 3 days post-infusion was reduced by 66%. A moderate overall reduction in morbidity was also achieved. It is calculated that to reduce the incidence of bleeding in severe haemophiliacs by 15% would require a 73% increased usage of therapeutic materials. More than twice this amount of material is likely to be needed to reduce the bleeding frequency of the same group by 66%.

Adolescent↗