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Biomedical subjects

M Small

Publications and source records attributed to M Small.

193 records · Page 11Linked to original sources
PubMedDate not supplied

Indications for fetal echocardiography.

Congenital heart disease is one of the most common congenital malformations diagnosed in liveborns. As more women undergo prenatal diagnosis, the need for screening fetal echocadiography increases. The fetal, maternal, and familial indications for fetal echocadiography are outlined in order to improve the identification of women in greatest need for this screening modality.

Echocardiography↗
PubMedDate not supplied

DNA repair in thymocytes of mice undergoing thymic involution.

DNA repair in mouse thymocytes before the onset of thymic involution was compared to that at successive stages during involution of the thymus. Repair of DNA in these cells after in vitro X-irradiation was evaluated by sedimentation of nucleoids in a sucrose gradient, as a measure of DNA supercoiling. DNA repair continued to function in the thymocytes even at ages when there was a dramatic reduction in the number of cells in the thymus.

Aging↗
PubMedDate not supplied

Visual evoked potentials in a patient with prosopagnosia.

Visual evoked potentials (VEPs) were recorded from a 53-year-old man with prosopagnosia during presentation of slides of known and unknown faces and under two control conditions. ANOVA comparisons with a normal male group showed no differences in P100 amplitude, P300 amplitude or P300 latency. There were no significant evoked potential differences between the patient and controls specifically related to the face conditions. There was, however, a significant delay in the latency of P100 from both hemispheres during all types of stimuli. This prolonged latency was asymmetrical, showing a right sided emphasis with the control conditions: pattern reversal and slides of geometric designs. This finding, of a dissociation in the interhemispheric delay, provides physiological evidence of stimulus-specific organisation at an early, sensory level. The fact that the P100 component showed a marked delay, yet P300 fell within normal limits for amplitude and latency, suggests that this patient's problem lies at a perceptual level.

Agnosia↗
PubMedDate not supplied

Macrosomia in pregnancy complicated by insulin-dependent diabetes mellitus.

We assessed the factors influencing the birth weight of infants born to 83 women with insulin-dependent diabetes mellitus (IDDM) over a 5-yr period. Maternal glycosylated hemoglobin (HbA1) concentrations at delivery correlated with the percentile birth-weight ratios (r = .43, P less than .001) and indicated that approximately 18% of variance in the birth weight could be ascribed to glycemic control in the third trimester. Fetal macrosomia occurred in 22 (27%) pregnancies. When 20 of these pregnancies were compared closely with 20 nonmacrosomic pregnancies in diabetic women, the mothers of macrosomic infants were found to be more obese, have a history of previous macrosomic birth, and have higher concentrations of serum human placental lactogen and urinary estriols in the third trimester. Macrosomic pregnancy was further distinguished by accelerated fetal growth (judged by serial ultrasonography) from the 32nd wk of gestation and by biochemical (but asymptomatic) hypoglycemia in the neonate. In our study, no serious neonatal morbidity could be attributed to macrosomic pregnancy. Good glycemic control was attained in both groups, and no significant differences between the groups in overall glycemic control throughout pregnancy were noted. Thus, despite good glycemic control, macrosomia remains comparatively common in modern pregnancy complicated by IDDM, and factors other than maternal hyperglycemia must contribute to its etiology.

Adolescent↗
PubMedDate not supplied

Saying goodbye in the intensive care unit: helping caregivers grieve.

The need for critical care caregivers to complete their own grief work when a patient dies deserves special attention. Positive coping with grief and loss can be encouraged through formal programs and individual and group memorial services.

Adaptation, Psychological↗
PubMedDate not supplied

Laryngeal tuberculosis: an unsuspected danger.

It is always important to treat conditions which may be cancerous with respect and, where there is suspicion, to take biopsies for histological examination. A hoarse voice may, in addition, be a sign of tuberculosis of the larynx, and the clinical appearance can be similar to a carcinoma. Preoperative chest x-ray (not always performed) and an awareness by the histologist of such a possibility are important now that this condition is increasing in frequency in parallel with conditions where immunological status is compromised.

Biopsy↗