Biomedical subjects

M Soldán

Publications and source records attributed to M Soldán.

3 recordsLinked to original sources

PubMed1999

Hydroxyapatite-collagen-hyaluronic acid composite.

The new composite biomaterial made from hydroxyapatite and collagen conjugated with hyaluronic acid has been studied. The structure evaluation of the composite showed more dense arrangement due to the formation of collagen hyaluronic acid conjugate, and particles of inorganic component are closely anchored in the structure. Mechanical properties and model swelling of this composite are compared with properties of hydroxyapatite-collagen composite of similar material without hyaluronic acid. Higher cohesivity of the new biomaterial can give new possibilities for application as bone implant material. The test of contact cytotoxicity showed a very good biocompatibility of the biomaterial.

Biocompatible Materials↗

PubMed1996

Properties of collagen and hyaluronic acid composite materials and their modification by chemical crosslinking.

This article describes properties of composites of collagen-hyaluronic acid shaped to layered materials. According to the results, interactions of these two polymers are very strong. The properties can be influenced by chemical crosslinking using glyoxal and starch dialdehyde. The different behavior during enzymatic degradation by collagenase and in swelling experiments is discussed in relation to material composition. The valuable properties of the composites observed in this study show the possibility of their use as biomaterials.

Achilles Tendon↗

PubMed1994

Depolymerization reactions of hyaluronic acid in solution.

Samples of microbial sodium hyaluronate were degraded by heating, ultrasonication ultraviolet (UV) and gamma-ray irradiation and enzymatic treatment. The weight-average molecular weight, Mw, of hyaluronate in 0.15 M NaCl and 0.06 M Na2HPO4 was determined by gel filtration with UV detection. The Mw of the degraded samples varied from 8 x 10(4) to 1.38 x 10(6). Depolymerization processes can be described by linear relationship (1/Mw)2 = f(t) in the case of ultrasonic treatment and by non-linear relationships in the cases of heating and UV irradiation at 257 nm. Gamma-ray irradiation and enzymatic treatment caused chemical degradation and depolymerization to oligosaccharides, respectively.

Animals↗