[Compliance with treatment in schizophrenia and mood disorders].
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Antidepressive Agents↗
Biomedical subjects
M Sorvaniemi
Publications and source records attributed to M Sorvaniemi.
Improved diagnostic assessment of major depression in psychiatric outpatient care in Finland.
The accuracy of diagnosis of major depression by psychiatrists, psychiatric residents, and other physicians in outpatient psychiatric care settings in Finland was examined. A total of 232 patients who visited four mental health centers in the hospital district of Satakunta during three years (1989, 1992, and 1995) were retrospectively given a diagnosis of first-episode major depression by researchers, based on chart reviews. These diagnoses were compared with those made by the evaluating clinicians. Accurate diagnosis was associated with the specialty of the physician and the location of the mental health center. Recognition of major depression significantly improved over the time period, which could be attributed to educational efforts, increasing familiarity with DSM-III-R criteria, and use of new antidepressants.
Adult↗
Recognition and management of major depression in psychiatric outpatient care: a questionnaire survey.
We studied the ability of psychiatric practitioners to recognize and treat major depression in standard clinical practice in Finland. A questionnaire with 18 items (including, e.g. physicians characteristics, two case reports and diagnostic and treatment proposals for both of them) was sent to 255 physicians in communal psychiatric outpatient care, 216 physicians responded (85%). Results suggest that diagnostic accuracy was good. Treatment proposals showed high sensitivity and lower specificity when the use of antidepressive medication was examined. This may reflect increased education concerning the illness and the effect of the new antidepressants, which are probably considered easier to initiate, or may be partly due to systematic error. Physicians characteristics determined neither diagnostic nor treatment decisions.
Adult↗
Microspectrofluorometric quantitation of autofluorescent lipopigment in the human sympathetic ganglia.
The age-related changes in lipopigment autofluorescence were studied by microspectrofluorometry in three different types of human neurons: the sympathetic neurons of the stellate and superior mesenteric ganglion and pyramidal neurons of the frontal cortex. The age-related increase in lipopigment autofluorescence was more rapid in stellate ganglion but similar linear increases were found also in superior mesenteric ganglion and frontal cortex. There was an age-related shift in the autofluorescence from yellow to orange in the ganglia. This may be due to the accumulation of neuromelanin in noradrenergic neurons. Lipopigments were identified in sympathetic neurons at the age of 4 months and all neurons carried pigment granules after the age of 64 years. It is concluded that lipopigment autofluorescence is a useful marker for cellular ageing in both the peripheral and the central nervous system.
Ganglia, Sympathetic↗