On the use of vecuronium 0.01 mg/kg to prevent suxamethonium-induced myalgia.
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Biomedical subjects
Publications and source records attributed to M Sosis.
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To assess the possibility of indirect damage by CO2 laser reflection from specialized or modified tracheal tubes, four different tracheal tubes were studied. They were (1) a Rusch red rubber tracheal tube wrapped with 3M No. 425 aluminum foil tape, (2) a Rusch red rubber tracheal tube wrapped with Venture copper foil tape, (3) a polyvinylchloride tracheal tube wrapped with Laser-Guard protective coating, and (4) a Mallinckrodt Laser-Flex tracheal tube. The tracheal tubes were straightened and centered within cardboard cylinders and the laser set to 40 W was aimed to reflect from the tracheal tubes onto the cardboard. The times to combustion perforating the cardboard cylinders because of laser reflection were 1.41 +/- 0.54 (mean +/- SD), 1.73 +/- 0.93, 3.70 +/- 2.18, and 9.26 +/- 3.40 s for tracheal tubes 1, 2, 3, and 4, respectively. The differences between the times to combustion with tracheal tubes 3 and 1, 3 and 2, 4 and 1, 4 and 2, and finally, 4 and 3 were statistically significant. We conclude that the Laser-Guard-wrapped polyvinylchloride tracheal tube and the Mallinckrodt Laser-Flex tracheal tube were less reflective of incident CO2 laser radiation than the copper or aluminum-foil-wrapped red rubber tracheal tubes.
Metallic tapes have been shown to protect combustible endotracheal tubes from the CO2 laser; however, no adequate means of protecting such tubes from the Nd-YAG laser has yet been found. In this investigation, five different metallic tapes were evaluated as protection for red rubber endotracheal tubes from an Nd-YAG laser set to 50 W. Radio Shack no. 44-1155 and 3M no. 1430 were quickly perforated by the laser. Laser contact with the adhesive side of 3M no. 433 resulted in combustion. The nonadhesive side of the Venture copper tape was not affected by the laser; however, when its adhesive side was struck, a fire occurred. 3M no. 425 tape provided the best protection: no effect was seen when the laser was aimed at its nonadhesive side for 1 min, with only smoking of the tape evident when its adhesive side was tested. Finally, 3M no. 425 and Venture copper foil tapes were shown to be resistant to an Nd-YAG laser set to 110 watts in an atmosphere of 98% O2.
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Twenty ASA physical status Class III patients undergoing cadaver renal transplantation were studied. After 90 per cent T1 recovery, as determined by train-of-four measurement, from 1.0 mg.kg-1 succinylcholine to facilitate tracheal intubation, nine patients received atracurium 0.25 mg.kg-1 (Group I) and 11 patients received vecuronium 0.05 mg.kg-1 (Group II) intravenously. The following measurements were made: time to maximum block onset (first dose Max), injection to start of recovery (start REC1), injection to 25 per cent T1 twitch recovery (REC 251), injection to 75 per cent T1 (REC 75(1], injection to 90 per cent T1 (REC 90(1] and time from 25-75 per cent recovery T1 (REC 25-75(1]. Maximum blockade (Max block 1) was also measured. At 90 per cent T1 recovery, if time permitted, an identical dose of the appropriate relaxant was administered. Time from second dose to onset of maximum block (second dose Max) and 90 per cent recovery after second dose (REC 90(2] were then measured. At the conclusion of surgery, neuromuscular blockade was reversed with neostigmine 2.5 mg and glycopyrrolate 0.5 mg. One way ANOVA was performed to determine significance between the groups and a p less than 0.05 was considered significant. A paired t test was also performed between REC 90(1) and REC 90(2) for atracurium and vecuronium respectively. A p less than 0.05 was again considered significant. Measurement of first dose Max, start REC1, REC25(1), REC 75(1), REC 90(1), REC 25-75(1) and Max block 1 revealed no difference between the patients receiving an initial dose of atracurium and those receiving vecuronium.(ABSTRACT TRUNCATED AT 250 WORDS)
Thirty ASA physical status I or II outpatients scheduled to undergo short procedures (less than 1 hr in duration) requiring tracheal intubation received either 1.0 mg/kg succinylcholine or 0.20 mg/kg (2.5 x ED95) or 0.25 mg/kg (3 x ED95) mivacurium. A N2O/O2/narcotic anesthetic technique was utilized and the ulnar nerve was stimulated with subcutaneous electrodes placed at the wrist. Tracheal intubation was attempted in all patients either 2 min after mivacurium or 1 min after succinylcholine. Intubation conditions were not different between the succinylcholine and mivacurium groups or between the two mivacurium groups. The onset and duration of neuromuscular blockade were shorter with succinylcholine than with mivacurium. Suppression of the T1 response to 90% of baseline occurred in 0.9 min with 1.0 mg/kg succinylcholine and at 2.2 and 1.5 min respectively, with 0.20 mg/kg and 0.25 mg/kg mivacurium. Initial recovery of the T1 response occurred at 6.4 min after 1.0 mg/kg succinylcholine and 12.7 and 13.6 min respectively after 0.20 mg/kg and 0.25 mg/kg mivacurium. Subsequent to initial recovery from the intubating dose of relaxant, infusions of mivacurium or succinylcholine were administered to maintain approximately 95% block. The mean infusion rates were 6.6 micrograms.kg-1.min-1 mivacurium and 41.2 micrograms.kg-1.min-1 for succinylcholine. Spontaneous recovery from neuromuscular blockade occurred more quickly after succinylcholine than after mivacurium: the time from cessation of infusion to recovery of T1 to 95% of baseline was 6.5 min in patients given succinylcholine and 16.7 min in patients given mivacurium. When reversal was in order, residual mivacurium-induced blockade was readily antagonized by 0.045 mg/kg neostigmine.(ABSTRACT TRUNCATED AT 250 WORDS)
A comparison was made of the incidence of postoperative myalgia (POM) and fasciculations when atracurium (ATR) or d-Tubocurarine (DTC) was given prior to succinylcholine (SDC) for facilitation of tracheal intubation. The subjects were 44 ASA physical status I or II outpatient females undergoing laparoscopy. They were assigned to one of three groups: Group 1 received 0.025 mg/kg ATR; Group 2 received 0.05 mg/kg DTC, and Group 3 received saline (NS). Thiopental was administered one minute and 45 seconds after pretreatment. Three minutes after pretreatment, SDC 1.5 mg/kg was given, and fasciculations were recorded on a scale of 0-3. The patients were questioned one and three days postoperatively about POM and their responses recorded using a scale of 0-3. Fasciculations occurred in 79% of patients given saline, in 46% of those receiving ATR and in 12% of those given DTC. Eighty-five percent of ATR patients were free of POM on postoperative day one. The corresponding figures for DTC and NS were 59% and 43%, respectively. The difference between ATR and NS achieved statistical significance, leading to the conclusion that DTC is a better defasciculant than ATR. DTC was, however, not significantly better than NS in the prevention of POM. Findings suggest that ATR may be the drug of choice for the prevention of POM.
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