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Biomedical subjects

M Sowa

Publications and source records attributed to M Sowa.

At least 145 records · Page 8Linked to original sources
PubMed1989

Cancer of remnant stomach following gastric surgery for benign conditions.

Eighteen patients received gastrectomy for primary cancer of the gastric remnant were studied clinico-histopathologically. Gastric ulcer had been the most common condition requiring previous gastric surgery, and Billroth II resection had been the most often employed procedure. The cancer of the gastric remnant was in an advanced stage in all patients. Tumors were detected in the sutured or anastomosed region (especially the latter) of the remnant stomach in a great majority of the patients studied. In spite of combined resection of the adjacent organs, such as spleen, pancreas and colon in most patients, curative resection could be done in only a half of them and the prognosis was poor in general. These observations seem to stress the importance of following up gastrectomized patients periodically and precautiously by endoscopic examination with multiple biopsy, because early detection of cancer of remnant stomach may lead to improvements in therapeutic results.

Aged↗
PubMed1989

[An analysis of DNA histogram and the expression of carbohydrate antigens regarding the degree of malignancy in gastric cancer].

We investigated both DNA histogram and the expression of carbohydrate antigens concerning to 168 patients with gastric cancer. Gastric cancer with type II DNA ploidy pattern showed a high incidence of vascular invasion and liver metastasis in the DNA analysis. Furthermore, ten patients with Stage II died of recurrence of gastric cancer within 2 years, of these nine patients showed type II or III DNA ploidy pattern. Then, gastric cancer with type II or III DNA ploidy pattern showed a high incidence of the expression of carbohydrate antigens, where they tended to distribute to cytoplasm and stroma. In conclusion, an analysis of nuclear DNA content appeared useful to predict prognosis in gastric cancer, in which type II DNA ploidy pattern showed the highest degree of malignancy, and both the expression of carbohydrate antigens and their localization possibly fill the role of parameter of the degree of malignancy.

Antigens, Tumor-Associated, Carbohydrate↗
PubMed1989

An immunohistological study of gastric cancer--with special reference to the expression of carbohydrate antigens and nuclear DNA ploidy patterns.

The expression of carbohydrate antigens specific to Span-1, CA 19.9, and SLEX in cancer tissues and nuclear DNA ploidy patterns were studied from tissue specimens of lesions excised from 137 patients with gastric cancer. The frequency of detection of each antigen was augmented with advanced invasion depth and progress in regional lymph node metastasis. In the cases which were positive for all three kinds of antigens, lymph node metastasis and lymphatic or venous invasion were detected with significantly higher frequencies than in the negative cases. The DNA histograms showed a DNA ploidy pattern of Type Ia or Ib in the cases negative for these antigens and a non-diploid or aneuploid pattern of Type II or III in many of the positive cases. These findings suggest that an immunohistological study of gastric cancer using monoclonal antibodies, combined with a nuclear DNA ploidy analysis, might be useful for understanding malignancy of the tumour.

Adenocarcinoma↗
PubMed1988

An analysis of the DNA ploidy patterns of gastric cancer.

This article deals with DNA measurements by fluorometry of nuclei in 33 freshly obtained specimens and in 109 fixed specimens of gastric cancer in Japanese patients. Histograms of the DNA measurements can be classified into four types (Ia, Ib, II, III). The nuclear DNA patterns had definite, if not significant, correlations with clinical and histologic parameters. For example, 88.2% of the cases classified as Type III were advanced stage disease, whereas early stage cases were predominant in Type Ia. Type II and III were frequently found in hepatic, peritoneal, and lymph node metastasis. The rate of occurrence of polyploid cells was significantly higher in the group with hepatic or lymph node metastasis than in the other group without metastasis. The results of this study show that fluorometric measurement of nuclear DNA is considered one method of determining the biological activity of gastric cancer cells.

Adenocarcinoma↗
PubMed1988

[A case of plasmacytoma (IgD lambda) of the breast associated with multiple myeloma].

A case of secondary plasmacytoma (Ig. D. lambda) of the breast, associated with multiple myeloma, is reported, involving a 60-year-old woman in whom multiple tumors of the right breast appeared during the course of her treatment for multiple myeloma. These breast tumors were firm, non-tender, clear-margined, smooth-surfaced, and showed good mobility. An ultrasonogram revealed that the tumors had the shape of a clear-margined anechoic mass like a cyst. A histological diagnosis of a biopsied specimen determined plasmacytoma (Ig. D, lambda) and the patient was treated with chemotherapy which caused the tumors to greatly reduce.

Breast↗
PubMed1987

A comparative study of experimental and human pancreatic carcinoma with special reference to histochemical findings.

This study was undertaken in order to histochemically investigate the mucoid substances (acid mucopolysaccharide and sialic acid) in experimental and human pancreatic carcinoma. The degree of alcian blue staining in the ductal and interstitial portions of the pancreas increased, especially in hamster tubular adenocarcinoma which had been induced by N-nitrobis (2-hydroxypropyl) amine. The pancreatic carcinoma of the rats, induced by di-methyl benz (alpha) anthracene, was usually poorly differentiated carcinoma, in which alcian blue and toluidine blue staining was high in the interstitial portion when compared with that of the hamster pancreatic carcinoma, which was usually well differentiated. The rates of enzyme digestion of acid mucopolysaccharide and sialic acid showed more prominently in the rat pancreatic carcinoma than in the hamster pancreatic carcinoma. Mucoid substances in the ductal portion of human pancreatic carcinoma revealed properties similar to those of hamster pancreatic carcinoma whereas those in the interstitial portion were similar to those of rat pancreatic carcinoma. These results suggested that mucoid substances, especially acid mucopolysaccharide, both in experimental and human pancreatic carcinomas, may play an important role in tumor growth.

Adenocarcinoma↗
PubMed1987

[A case of a carcinoid of the duodenum (somatostatin-, serotonin- and ACTH-producing) with carcinoma of the stomach].

A case of a duodenal carcinoid which was producing somatostatin, serotonin and ACTH in a 65-year-old man is reported. The patient was found to have a submucosal protruded mass of the duodenal bulb and a tumor mass-like IIa + IIc in the antral portion of the stomach. Subtotal gastrectomy was performed and the histological diagnosis of the tumors were found to be a classical carcinoid of the duodenum and a well-differentiated tubular adenocarcinoma of the stomach. The carcinoid cells of the duodenum had numerous cyto-plasmic granules which were positive by Grimelius staining and negative by Hellerström-Hellmann staining, and 200-300 nm in size, electronmicroscopically. These cells were shown to contain somatostatin, serotonin or ACTH-positive cells by means of monoclonal immunohistochemistry, however, results were negative for gastrin, insulin, glucagon, calcitonin, VIP or PP.

Adenocarcinoma↗
PubMed1986

Effects of sulpiride-induced hyperprolactinemia on human ovarian follicles during the late follicular phase.

The effect of hyperprolactinemia during the midfollicular through the late follicular phase of the menstrual cycle on follicular development and follicular fluid hormone concentrations was studied. Fourteen women underwent laparotomy in the late follicular phase for gynecologic reasons; 6 were treated with sulpiride daily from the midfollicular to the late follicular phase (sulpiride group) and 8 received no treatment (control group). Daily administration of sulpiride (150 mg orally) significantly elevated serum prolactin (PRL) levels in all six women. In the small follicles (less than or equal to 8 mm in diameter), follicular fluid 17 beta-estradiol (E2) concentration was significantly lower (P less than 0.01), and testosterone (T) concentration was higher (P less than 0.05) in the sulpiride group. In the large follicles (greater than or equal to 9 mm in diameter), however, follicular fluid E2 and T concentrations showed no significant differences between the sulpiride and control groups. In the sulpiride group, the mean diameters of the follicles were significantly smaller than in the control group (P less than 0.01). These observations suggest that PRL exerts a suppressive effect on the smaller but not the larger follicles during the late follicular phase.

Adult↗
PubMed1985

Relationship between human oocyte maturation and different follicular sizes.

The relationship between the follicular size in the human ovary and oocytes capable of resuming meiosis in vitro was examined in each phase of the menstrual cycle. Intact healthy oocytes with corona cells obtained from small (3-4 mm diameter), medium (5-8 mm diameter) and large (9-15 mm diameter) antral follicles were cultured at 37 degrees C for 43 h. At the end of the culture period the denuded oocytes were examined morphologically to determine whether the resumption of meiosis had occurred. In the follicular phase, the percentage of oocytes resuming meiosis (polar body extruded: PB) in the large-follicle group was significantly higher than that in the small-follicle group (P less than 0.05). The incidence of oocyte maturation including only nuclear maturity seemed to increase as follicles increase in size. However, in the luteal phase the incidence was fairly constant, irrespective of the follicular size. These results suggest that the capacity of human oocyte maturation is closely correlated with follicular maturation.

Adult↗
PubMed1985

[A case of primary lymphoma of the stomach, diffuse lymphoplasmacytic type, with massive hematemesis].

A case of primary lymphoma of the stomach with massive hematemesis and melena who underwent emergency gastrectomy is reported. The patient was a 72-year-old woman. The tumor was 3.5 X 3.0 cm in size and occupied the posterior wall of the upper part of the gastric body. The surface of the tumor was covered with hematoma, and was there was a lack of gastric mucosa. Histological diagnosis of the tumor was primary gastric lymphoma, diffuse lymphoplasmacytic B-cell type, and monoclonal kappa-light chain was demonstrated by the immunohistochemical method. The bleeding source of the tumor tissues was a ruptured artery invading the tumor tissue in the submucosal layer of the stomach.

Aged↗
PubMed1985

Electron microscopic studies of human pancreatic adenocarcinoma.

Tissue samples from 12 patients with pancreatic carcinoma were studied by light and electron microscopy. Ten were diagnosed as adenocarcinoma by light microscopy. However, three different electron microscopic findings were observed among these ten adenocarcinomas. One showed that the tumour cells had large nuclei with poorly developed intracellular organelles. Many mucinous granules, well developed cellular projections and intracellular microcysts were observed. In the second findings were different in that these cells had no granules. The intracellular organelles were developed poorly and abundant microvilli and cellular projections were observed. These observations suggest that the tumour cells may arise from pancreatic ductular cells. The third specimen showed a completely different appearance. There were pleomorphic nuclei with enlarged nucleoli and the cytoplasm contained swollen mitochondria, a well developed rough endoplasmic reticulum and varying numbers of zymogen-like granules. Occasionally, the zymogen-like granules were absent. These characteristics resemble the de-differentiation of acinar cells which has been repeated in experimental pancreatic carcinoma. These results suggest that careful examination of human pancreatic carcinoma may show more cells of acinar origin.

Adenocarcinoma↗
PubMed1984

[Ultrastructural observations of human pancreatic duct cell carcinoma].

The great majority of human pancreatic duct cell carcinoma are thought to be of ductal origin and acinar cell carcinoma has been reported to be very rare. This paper reports electron microscopic observations of human pancreatic duct call carcinoma. The results were as follows. In the cases which were diagnosed as well or moderate differentiated adenocarcinoma of the pancreas by light microscope, three different types of tumor cells were observed by electron microscope. Two of them had characters of ductal cells. The origin of these tumor cells were considered to be originated from the relative large and small pancreatic ducts. Third type was a little different from cell types mentioned above. Some of these cells had swollen mitochondria and well developed rough endoplasmic reticulum with a various distribution of zymogen granules. Microvilli and cellular projects were scant. These findings were considered to be the dedifferentiation of the acinar cells and this type belonged to be acinar cell carcinoma.

Aged↗
PubMed1983

Relationship among the status of the human oocyte, the 17 beta-estradiol concentration in the antral fluid and the follicular size.

We studied the relationship among the status of the human oocytes, the E2 concentration in the antral fluid and the follicular size in the different phases of the menstrual cycle, in order to determine the microenvironment of the follicles with healthy or degenerative oocytes in the human ovary. In the follicular phase of the menstrual cycle, follicles which contained a healthy but not degenerative oocyte had a significantly higher level of 17 beta-estradiol (E2). In the late follicular phase, the larger follicles (greater than or equal to 13 mm, in diameter) had only health oocytes. It seems that the follicle containing a degenerative oocyte does not develop physiologically until maturation of the preovulatory follicle. In the luteal phase, there were no relationships among the status of the oocyte, E2 concentration in the antral fluid and the follicular size. However, the E2 levels of the antral follicles with healthy oocytes in an ovary with corpus luteum were significantly lower than those in the contralateral ovary. The results suggest that the corpus luteum may exert an influence on the adjacent follicles.

Adult↗