Biomedical subjects
Publications and source records attributed to M Spacek.
The 63-membered total of patients is referred to with clinical signs of transient ischaemic attacks (TIAs) in carotid supplied area in account to the risky factors, results of selective auxiliary testing methods as well as the disease prognosis providing harmful occurrence of cerebral palsy completed.
Results obtained from EEG examination and Doppler sonography in a group of 155 patients were studied and special attention was paid to ischemic cerebral lesions in stenotic processes in carotid arteries. Pair correlations of individual factors were statistically analyzed using a computer, i. e., results obtained from EEG, Doppler sonography, patients' age and final diagnosis. High statistical mutual dependence of both the methods was found which may be explained by the functional approach pursued in both the procedures. The contribution of both the methods to rapid and considerate diagnosis of vascular cerebral lesions is emphasized here.
Significance of EEG findings for prognosis of further development in paroxysm is evaluated in this work in adult epileptic patients suffering from seizures which appeared in their childhood. The assessment is based on EEG made during the active phase of the disease and in the time when fits were compensated. Seizureless condition after discontinued medication was observed only in a group of patients with secondary type of epilepsy. We suppose these patients should remain under control since two thirds of them showed diffuse nonspecific changes, which means 50% risk of recurrence of seizures after discontinuation of drug therapy. When medication continued, 55% of patients remained without any fits, of this number in 21.6% seizures recurred on the average within seven years after experimental discontinuation of drug therapy in spite of frequently normal EEG findings. The fact that the group of compensated patients without medication did not include those with primarily generalized seizures can be explained by their good conditions observed even in their childhood and for this reason most of them were not treated in the Anti-Paroxysmal Centre.
Statistical significance of different factors in laterality of lesions in the carotid bed was studied on a group of 170 patients indicated to ultrasound examination. These were factors contained in the patients' history, i.e. ischemic heart disease, arterial hypertension, diabetes mellitus, age and sex of patients as well as results obtained from auxiliary examinations--Doppler sonography, KAG, EEG and CT of the brain. A marked statistical predominance of lesions in the left-side carotid bed was found, which was, however, true only for men, especially those after a completed stroke. The left-sided bed is, moreover, involved earlier, higher incidence of ischemic heart disease was also observed in left-sided lesions as well as more severe findings obtained from Doppler sonography, angiography, EEG and CT of the brain.
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