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Biomedical subjects

M Stamenković

Publications and source records attributed to M Stamenković.

10 recordsLinked to original sources
PubMed1998

Glaucoma simplex congenitum in the Veli Brgud village, the Opatija County, Republic of Croatia--a genealogical nine-generation study.

On the Ucka hill-side, in the Veli Brgud village, Opatija County, Istrian peninsula, Republic of Croatia, there is a great number of patients with glaucoma simplex congenitum (open angle glaucoma) among a total of 550 Croatian inhabitants. Of these, 536 (97.5%) were ophthalmologically examined and glaucoma simplex congenitum was diagnosed in 74 persons, some of them already blind. The proportion of the affected was 13.8%. The cases were largely from the Afrić family (nicknamed "Sor"). The pedigree of the Afrić-"Sor" family has 1215 members through nine generations, descendants of Matheus Afrić (1762) and Marija Bratović (1765). In the total of 536 examined, 291 (54%) belong to this pedigree, whereas 67 (90%) out of 74 affected persons were of the same pedigree. The rest of 7 (9.46%) affected patients did not descend from this pedigree, however, three of them (4.05%) were also from the Afrić-"Sor" family, but we could not find a connection with that pedigree due to inadeguate marital data before 1760. In the Veli Brgud village, there also were 4 (5.41%) patients of non-Afrić families with no other affected members. From the total of 330 marriages, 73 (22%) were consanguineous. According to our results, the mode of inheritance of glaucoma simplex in the Afrić-"Sor" pedigree was of a dominant pattern.

Consanguinity↗
PubMed1993

IgG, IgM and IgA umbilical blood concentrations in normal singleton vaginal deliveries with stinking amniotic fluid or intrapartal maternal febrility > or = 38 degrees C or duration of delivery > 12 hours.

Total of 321 preterm/term newborns delivered in normal singleton vaginal deliveries was studied. Babies were divided into two groups. The first one includes 62 newborns with single, isolated clinical sign: stinking amniotic fluid or intrapartal maternal febrility > or = 38 degrees C or duration of delivery > 12 hours. The second one (control group) contained 259 newborns with no such a sign. In both groups the umbilical cord blood IgG, IgM and IgA concentration (g/L) were quantified by a radial immunodiffusion method. The obtained values were classified into the groups according to 500-grams-birth-weight-ranges. The differences of the mean IgG, IgM and IgA concentrations between the each 500-grams-birth-weight-range subgroup separately in both control and experimental group so as between the same subgroup of the control and experimental group were tested by the means of the Student's t-test. Obtained results did not express the significant differences in the mean IgG, IgM and IgA umbilical cord blood concentrations between the experimental and control group of the newborns.

Birth Weight↗
PubMed1991

Beta 2-microglobulinuria in a population exposed to Balkan endemic nephropathy: inferences from repeated cross-sectional studies.

Baseline data from a study run in 1974, which comprised beta 2-microglobulinuria (beta 2mu) measurements at monthly intervals from 416 members in 112 households from the BEN affected village of Petka, were compared with the results of two subsequent, cross sectional studies. In June 1988, retesting involved 320 available persons from the same households. Another collection of 284 urine specimens took place in October 1989. Prevalence of tubular proteinuria was the same in 1988 and 1989 as it was in 1974, indicating that the level of exposure to nephrotoxic agent did not change over time. Over 94% of the individuals who were always beta 2mu negative in 1974 remained negative in 1988. By contrast, over two thirds (68.7%) of those who were positive two or more times 14 years ago, tested positive upon re-examination in 1988. Particular interest arises from the data on those initially repeatedly positive persons in whom the overt disease did not occur over time; moreover, some appeared to be unaffected in 1988 and 1989 according to our set of laboratory criteria. The results suggest occasional slow progression and even possible reversibility of tubular lesions in individuals living in the BEN affected environment.

Adult↗
PubMed1987

Shunt thrombosis prevention in hemodialysis patients--a double-blind, randomized study: pentoxifylline vs placebo.

Previous studies demonstrated a high incidence of local thrombosis in patients in whom external arteriovenous shunts were used for vascular access. This procedure provides, therefore, a useful model for the evaluation of potential antithrombotic agents. The effect of the hemorheologically and hemostasiologically active drug Pentoxifylline on the incidence of thrombosis of arteriovenous shunts (Ramires shunt) was investigated in a long-term, double-blind, placebo-controlled study in 51 patients on chronic hemodialysis. The two treatment groups were comparable in age, sex, concomitant medication, and dialysis program (three times per week for four hours). Drugs known to affect platelet function or coagulation were excluded, with the exception of heparin, during the dialysis procedure. All shunts were placed in the forearm and inserted into the distal part of the radial artery and basilic antebrachial vein. Simultaneously, for medical reasons, in all patients an arteriovenous fistula was performed (proximal part of radial artery and cephalic antebrachial vein). Shunt thrombosis was assumed when the flow in the shunt discontinued under visual and auscultatory control. Thrombi were documented by physical removal from the arterial part of the shunt by use of gentle suction or by complete shunt thrombosis (both arterial and venous part of the shunt). Thereafter, the patients' trial period terminated. The total number of thrombi during the observation period was 44 in the pentoxifylline group (26 patients), compared with 82 in the placebo group (25 patients). The mean number of thrombi per patient was 1.69 +/- 1.29 in the pentoxifylline group, significantly lower than that in the placebo group (3.28 +/- 1.99/p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

[Effect of aging on visual evoked potentials].

Experimental and clinical studies, aiming to establish the influence of aging on latence, amplitude and types of waves of visual evoked potentials (VEP) are numerous. It was concluded that P-100 latence prolonged with aging, particularly after the age of 55, while P-100 amplitude had been gradually decreased during the life. During the aging, senile changes in the eye and optic nerve (for example, senile miosis, degenerative retinal changes, geniculostraital defect) can be reflected to the changes in VEP (P-100). Aim of our study was to establish if the aging influences the alteration in latence and wave amplitude in VEP, as well as to standardize normal values of VEP in different ages. VEP was registered in 135 subjects classified into 3 groups. Group I comprised 49 subjects, aged 17-30 (average age 20.92 years), group II comprised 34 subjects aged 31-54 years (average 42.55 years). Group III--over 55 years (average age 69 years) comprised 52 subjects. There were 55 females and 80 males. Results have shown that the mean value of amplitude for both eyes in the first two groups of younger subjects was 9.03 microV and 8.91 microV, respectively, while in the group of older subjects, it was slightly decreased--8.54 microV. P-100 latence prolonged insignificantly until the age of 55, and afterwards in every 5 years it increased for 1.5 ms. Amplitude was insignificantly lower latence in VEP was insignificantly prolonged until the age of 55, and afterwards, the increase was significant. Amplitude was decreased insignificantly, gradually during the life.

Adolescent↗
PubMedDate not supplied

[Vitreoretinal surgery in war injuries of the eye].

Results of vitreoretinal surgeries of 647 severe penetrating injuries of the eye, sustained during the war operations in the territory of former Yugoslavia, in the period from 01.07.1991. to 31.12.1998. were analyzed in the paper. A total of 558 pars plana vitrectomies, 459 intrabulbar foreign bodies' extractions and 360 surgeries of traumatic retinal detachments (89 in the conventional way) were performed at the Clinic of Ophthalmology--Department for Vitreoretinal Surgery of the Military Medical Academy. Certain innovations in the surgical treatment of the severely injured eye with the damage of posterior eye segment, as well as the lens, were presented. In those cases, (simultaneously with pars plana vitrectomy, and extraction of retained intrabulbar foreign body), the primary intraocular lens (IOL) implantation was also performed, particularly posterior chamber IOL implantation following lensectomy, as well as phacoemulsification.

Eye Foreign Bodies↗
PubMedDate not supplied

[Acute renal failure following necrosis of a myoma in the puerperium].

The case is presented of a 36-year-old secundipara with the uterine myoma and a mild form of EPH gestosis. She became icteric and anuric on the sixth day after a spontaneous vaginal delivery and an apparently uneventful early puerperium. Blood coagulation tests were characteristic of disseminated intravascular coagulation (DIC). Since it is postulated that the appearance of DIC could be connected with the probable necrosis of a preexisting uterine myoma, abdominal hysterectomy was performed on the 8th puerperal day. Because of a persisting acute renal failure with highly elevated BUN levels and creatinine, the patient was subjected to haemodialysis every day during the next 73 days. After 3 months of this treatment she was discharged from hospital with a reduced but satisfactory renal function. The pathogenesis of DIC and acute renal failure following necrosis of the uterine myoma is discussed.

Acute Kidney Injury↗