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M Stawarz

Publications and source records attributed to M Stawarz.

9 recordsLinked to original sources
PubMed1983

Occurrence of HLA antigens in patients with ankylosing spondylitis and in their families.

The HLA typing (A and B loci) was performed in 55 individuals with ankylosing spondylitis (a.s.) in 74 relatives of their families and in 394 normals. HLA B-27 antigen was found in 80% of tested patients with a.s. The relative risk for B-27 being 30.1 and for A2 -- 1.65. In patients with a.s. lacking B-27 antigen the course of the disease did not differ from that in B-27 positive subjects. Uveitis has been revealed in 36.4% of B-27 patients and only in 9.9% of those negative for B-27. The results obtained in families display four different patterns as concerns genetics and morbidity: 1) in all 3 generations the presence of B-27 was accompanied by a.s., 2) in none of tested family members (diseases or healty) the B-27 antigen was confirmed, 3) there was correlation between B-27 and the disease symptoms, 4) the incidence of a.s. was associated with B-27 homozygotism. The results favour the idea that B-27 antigen is a disease determining factor, however, there is probably another allelic gene (nes) cooperating with B-27 locus. The B-27 homozygotism increases markedly the risk for a.s. The course of the diseases seems to be determined by environmental factors.

Female↗
PubMed1982

Genetic polymorphism of FUC (EC 3.2.1.51.) in Polish population.

In a sample of the Polish population numbering 271 persons three FUC phenotypes were encountered by cellulose acetate gel isoelectric focusing (CAGIF). The frequencies of FUC1 and FUC2 genes were 0.653 and 0.347, respectively. The FUC system has proven to be of high value for paternity testing.

Gene Frequency↗
PubMed1982

Psoriasis vulgaris and pustulosis palmaris et plantaris and the HLA system.

The frequency of locus A and B antigens in 39 patients with pustulosis palmo-plantaris and in 16 patients with psoriasis vulgaris was determined in comparison with a control group of 394 healthy subjects. The data obtained in the psoriasis vulgaris group confirmed the literature data (increased frequency of B 13 and B 17 antigens). In the pustulosis palmo-plantaris group only the patients with the histopathologically confirmed psoriasis pustulosa showed a statistically significant increase of B 12 antigen which has not been reported so far.

HLA Antigens↗
PubMed1981

Salivary secretion of blood group substances in multiple sclerosis patients.

Inspired by the widely discussed problem of a possible genetic background of multiple sclerosis we have undertaken a trial of determining the relationship between the hereditary trait conveyed by a single gene, i.e. the salivary secretion or nonsecretion of blood group substances, and the occurrence of this disease. The investigations have shown that in the population of western Poland the nonsecretors of blood group substances into their saliva have a statistically significant chance of developing multiple sclerosis than secretors of these substances.

ABO Blood-Group System↗
PubMed1979

Anti-tumor antibodies in lung cancer patients. Immunofluorescence study using various indicator cells.

By means of indirect immunofluorescence a number of primary lung cancer patient sera and control sera were tested for anti-tumor antibody activity on living tumor cells as a substrate. Antibodies against surface antigens were the most frequently detected in autologous system (in 65%) on cells derived from fresh surgical material of lung cancer. They were also found in 50% of cases using tumor cells from primary short-term culture. When established cell line of lung cancer was used (E-14) in allogeneic system, the antibodies were detected in only 22% of examined lung cancer sera. Absorption of positive sera with homogenates of normal tissues did not abolish their specific activity. Positive reactions were confined to squamous cell type of bronchogenic carcinoma.

Antibodies, Neoplasm↗
PubMed1975

HL-A matching in thrombocyte and leukocyte transfusions.

A panel of 150 Rh+ and Rh-- donors was tested by the NIH-microcytotoxicity test against 90 antisera determing 21 HL-A antigens. For platelet and leukocyte transfusions, donors compatible in ABO and Rh groups as well as in HL-A antigens, were used. In some cases the donor and recipient were compatible in three HL-A antigens, in other cases the degree of compatibility was less satisfactory. Platelet and leukocyte concentrates were prepared by double thrombo- and leukocyte-pheresis. Before transfusions the cross cytotoxicity test with donor's lymphocytes was performed. No transfusion accidents occurred; in some patients a beneficial effect was noticed.

ABO Blood-Group System↗
PubMedDate not supplied

[Diagnostic evaluation of HLA sera obtained as a result of cooperation between the Institute of Hematology and blood donation stations].

The aim of the cooperation between the Laboratory of Leucocyte and Platelet Immunology, Institute of Haematology and Blood Donation Stations was typing of anti-HLA sera from the blood of pregnant women. During 18 months of this cooperation 477 sera were studied. In 255 sera (53.1%) lymphocytotoxic antibodies were demonstrated and their specificity was determined. The types anti-HLA sera will be used for determination of HLA antigens in blood donors donating blood in the Stations. The results of these determinations, technical problems and conclusions drawn from this cooperation are discussed. Continuation of this cooperation will contribute to further limitation of the import of anti-HLA sera.

Antilymphocyte Serum↗