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Biomedical subjects

M Steinbach

Publications and source records attributed to M Steinbach.

At least 19 recordsLinked to original sources
PubMed2001

Torsades de pointes caused by Mibefradil.

We report a case of symptomatic Torsades de pointes due to QTc prolongation by Mibefradil, which potentially explains unexpected deaths related to this drug. Multiple episodes of Torsades de pointes were documented in a 76-year-old woman with significant QTc prolongation of 0.53 s. After discontinuation of Mibefradil QTc intervals normalized and no further ventricular tachyarrythmias were observed. We conclude that Mibefradil can cause QTc prolongation and life threatening ventricular dysrhythmias.

Aged↗
PubMed1995

[Primary seminoma. A rare mediastinal tumor].

This is a report on three patients with primary mediastinal seminoma. Two patients had no symptoms, and one had had thoracic pain for the last few years. The preoperative diagnosis was thymoma in all cases, and in one patient the radiologist had suspected a seminoma. We removed the tumor after performing median sternotomy (n = 2) and anterolateral left thoracotomy (n = 1). The presence of a primary gonadal seminoma was excluded with a urological and ultrasound examination. All patients are still alive following adjuvant chemotherapy (n = 2; 120 and 8 months) and radiotherapy (n = 1; 84 months). Chemotherapy consisted of four cycles of cisplatin, etoposide and ifosfamide or combination therapy with cisplatin, bleomycin and velbe.

Adult↗
PubMed1995

On the role of extraretinal signals for saccade generation.

We investigated the accuracy of sequential saccadic eye movements, executed without visual feed-back. We found evidence that the final error of one saccade is corrected during the next, which supports the existence of extraretinal inputs to the saccadic generator. The corrections, however, were incomplete, which suggests that extraretinal signals are only partially effective.

Eye Movements↗
PubMed1994

Hemifield relative motion bias in adults monocularly enucleated at an early age.

A psychophysical study of relative motion discrimination for six subjects monocularly enucleated within 24 months of birth showed no significant difference in their thresholds for detecting relative velocity when compared with age matched control subjects. The study however highlighted a bias for the control group, age matched normals, which is consistent with a hemifield anisotropy for motion in normal observers reported by Smith and Hammond [(1986) Perception, 15, 111-117]. The bias however was found to be reversed for enucleates. This difference and individual differences reported in the Smith and Hammond study are discussed in terms of possible developmental changes which emerge when stereopsis is absent or weak.

Adult↗
PubMed1994

[Ergospirometric studies of normal probands for an unsteady-state increment test program].

One-hundred-sixteen healthy subjects (60 female and 56 male) with normal height (L) and weight (w) were selected to provide an even distribution of age (A, 20-70 years). All underwent an unsteady state cycle ergometer test with work increments of 20 watts each minute to exhaustion. A commercially available exercise testing system (EOS SPRINT, Jäger Corp., FRG) with gas analysis from a mixing chamber was used to study oxygen uptake (VO2), carbon dioxide output (VCO2), heart rate (HR), tidal volume (VT), breathing frequency (BR) and arterial oxygen tension (PO2) with special regard to the ventilatory anaerobic threshold (VAT) and maximum power output. For all parameters multiple regression equations were determined. Furthermore, heart rate reserve (HR-reserve), breathing reserve (VE-reserve), O2-pulse (VO2/HR), the dead space/tidal volume ratio (VD/VT) and the alveolar-arterial PO2-difference (AaDO2) were calculated. Day-to-day reproducibility was proven in 21 subjects. VO2max in females was 1584 +/- 300 ml/min (VO2max = -17 A + 10 L + 10 G + 58, r = 0.75, p < 0.0001), VO2AT 957 +/- 159 ml/min (VO2AT = 0.35 VO2max + 0.40 l/min, r = 0.77, p < 0.0001). The ratio VO2AT/VO2max was 50 +/- 7%. In male, VO2max was 2452 +/- 529 ml/min (VO2max = -23 A + 23 L + 9.5 G - 1395, r = 0.78, p < 0.0001), VO2AT 1209 +/- 213 ml/min (VO2AT = 0.29 VO2max + 0.51 l/min, r = 0.71, p < 0.0001), and VO2AT/VO2max 62 +/- 9%.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1977

[Dumping syndrome after selective vagotomy and pyloroplasty].

We have analysed the late complications (3--6 years after the operation) in 48 patients we treated by selective vagotomy and pyloroplasty because of duodenal ulcer. Authors have encountered six patients with so severe postoperative dumping syndrome that revison surgery has been performed. By reoperation there was no evidence of peptic disease but gastroduodenitis. After additional antrectomy dumping symptoms disappeared in all but one patient and radiologically the rate of test meal emptying of the stomach was reduced.

Dumping Syndrome↗
PubMed1975

Familial clustering of degenerative cardiovascular diseases.

In two geographical areas; the Gurghiu Valley, in a mountain region, and the village of Jurilovca on the shores of the Razelm lagoon, investigations were performed in 390 subjects of both sexes over 20 years of age, first degree relatives of healthy index subjects (males aged 40 to 60 years) and 298 subjects of both sexes over the of 20, first degree relatives of index-subjects with coronary heart disease and/or hypertension. The prevalence of these diseases was found to be 40% higher in the families of diseased subjects. The authors assume the participation of a genetic factor in the etiology of these two degenerative cardiovascular diseases.

Adult↗
PubMed1975

Coronary heart disease and risk factors in some special type collectivities.

Transversal epidemiologic investigations carried out in different populations from several regions of Romania : Gurghiu Valley (lumberjacks from a mountain region), Danube Delta and Razelm lagoon complex (fishermen), and Bucharest have shown that, in spite of the high caloric value of food and even of a high intake of saturated fats, mean serum cholesterol is lower in the rural areas than in Bucharest, probably owing to the strenuous physical work. However, except myocardial infarction, more frequent in the urban than in the rural regions, the other forms of coronary heart disease have a relatively higher frequency in villages, particularly atrial fibrillation and ECG signs of ischemia. These findings might be explained by a greater prevalence of hypertension in these populations. It is concluded that the risk factors, which act synergically, depend on the complex structure of the "ecologic niche".

Adult↗