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Biomedical subjects

M Steinhardt

Publications and source records attributed to M Steinhardt.

At least 37 records · Page 2Linked to original sources
PubMed1993

[Clinico-chemical blood values in newborn calves. 1. Effects of some internal and external conditions].

In a large dairy cattle herd blood samples taken by venipuncture in newborn calves within 0 to 12 hours after delivery were analysed for hematocrit and fifteen other variables. The time of birth and the time of blood sampling and of first colostrum supply were recorded as well as body weight, sex and breed of the animals. Blood sampling in dairy cows was performed in the course of a herd health programme. The effects of the above-mentioned factors on the blood values of calves were investigated. Comparing the blood values of the pregnant cows with those of their newborn calves led to the result that in calves the measures were higher than (Hkt, Thyroxine), equal to (urea, P, Ca, Zn, Mg, K, Na, TIBC) or below (total protein, albumin, gammaglobulin, cholesterol, coeruloplasmin, Fe, Cu) those of their dams. There was great scattering of the concentrations of Zn, Cu, Mg, Fe, TIBC, total protein, albumin and in hematocrit. Uptake of colostrum caused the concentration of Mg, total protein and gammaglobulin to increase and those of albumin and hematocrit to decrease, leaving the levels of P and blood urea unchanged.

Age Factors↗
PubMed1993

[Clinicochemical blood values in newborn calves. 2. Repeated studies in the same animals].

Blood samples taken by venipuncture in calves within 12 hours after delivery and again in the same animals within 5 to 23 days of postnatal life were analyzed for hematocrit and fifteen other biochemical values. The changes of blood values between these two sampling points in each individual calf were investigated by regression analysis. Remarkable individual reactions and effects of the constitution of the animal immediately after delivery on the level and on the changes of the biochemical values could be observed as well as great deviations of some blood values of twin calves too. The scattering of some blood values and their changes in the first days of postnatal life are discussed regarding the maturity of the calves as well as the possible incidence of deficiency states or the setting of a new level for these physiological values.

Animals↗
PubMed1993

[Observations on the maturity of stillborn calves].

Organ weight and trace element analyses were performed on 75 stillborn calves from the same dairy cow herd. The elements Fe, Mn, Zn and Cu were measured in the livers of 66 of the calves. The calves ranged in age from 259 to 299 days of gestation, and in weight from 18 to 58 kg. Based on the quotients of organ and other body parts, stage of growth of the humerus and age, the animals were grouped as either preterm (P), term but light (TL), and term with appropriate weight (TA) calves. In P group calves the heart, lungs, liver, kidneys, thymus, spleen and thyroid glands were relatively heavy. In the TL group calves the brain, heart, lungs and thyroid glands were relatively heavy whereas the spleen and thymus were comparatively light. The liver Fe and Zn values were lower in this group than in the other 2 groups.

Animals↗
PubMed1993

[Trace elements in the liver and myocardium of stillborn dairy calves].

Trace element analyses were performed on the livers of 52 and the heart muscle of 19 stillborn dairy calves. All calves originated from one herd and ranged in age from 260 days of gestation up to one day old. In the liver the trace element concentrations (mg/kg fresh weight) were as follows: Fe: 181.3 +/- 173.5; Zn: 74.6 +/- 37.7; Cu: 98.1 +/- 42.6; Mn: 1.4 +/- 0.36 and in the heart: Fe: 54.1 +/- 10.6; Zn: 16.3 +/- 3.8; Cu: 2.5 +/- 0.99; Mn: 0.42 +/- 0.07. Calves from heifers had lower Cu values. The relationship between trace element concentration and content and liver and heart weight is discussed, as are aspects of bioavailability and storage mechanisms as well as clinical signs of trace metal deficiencies.

Animals↗
PubMed1993

[Trace element supply of newborn calves. Effect of the mother and of the genetic makeup, sex and degree of maturity of the newborn].

Stillborn calves of a large dairy cattle herd were used for investigations of trace element (Fe, Zn, Cu, Mn) content of the liver and heart muscle. Trace element content varied markedly in the liver and in the heart muscle too but in the heart muscle with a smaller degree. Calves from heifers had a greater trace element content in the liver and heart muscle than those from cows. Premature calves had small amounts of Mn and Cu in their livers and small but term calves had less Fe and Zn in their livers. Single calves from cows had a greater amount of trace elements in the liver and heart muscle than twin calves.

Animals↗
PubMed1992

[Birth injuries in calves and perinatal calf losses in a large dairy herd].

Post-mortem examinations were carried out on 65 calves which were stillborn or died within 24 hours of birth. All calves came from a large dairy unit with about one thousand cattle of the Schwarzbuntes Milchrind breed. To evaluate the perinatal losses, the farm records of parturitions from 1985-1990 were used. The calves had gross damage of the CNS, the musculature, subcutaneous tissue and internal organs such as lung and intestines. It may be assumed that a lesser degree of similar damage would also be present in the surviving calves. The level of perinatal losses is determined particularly by deaths following prolonged parturition due to foetal oversize in heifers and young cows, but also by the birth of immature calves of low weight after pregnancy of normal or decreased duration and by twin pregnancies with high total calf mass and relative immaturity of the calves.

Animals↗
PubMed1992

[Birth weight and measurements of various body parts of stillborn calves of a large dairy cattle herd].

Stillborn calves (80 animals) originating from one dairy herd were used for studies on allometric measures in newborn calves. In the first approach some factors were neglected and only the effect of the calves' sex was considered. Differences in mean birthweight between male and female calves were reflected in organ and other body constituent weights too, but with different relations between them. Enlarged thyroid glands could be observed in both sexes but more often in female calves meaning that there is no correlation between thyroid size and body weight. Strong correlations of bones, muscles and outer body measures and looser ones of internal organs (thymus, liver, lung, kidneys, spleen) and endocrine glands (adrenal glands) with body weight were found especially in male calves. In some calves the sometimes enlarged liver looked like a fatty liver with its pale yellowish appearance and crumbly consistency.

Animals↗
PubMed1990

Health locus of control predicts free-living, but not supervised, physical activity: a test of exercise-specific control and outcome-expectancy hypotheses.

We statistically controlled fitness (1.5-mile run), outcome-expectancy values, and perceived barriers for physical activity and then compared internal health locus of control (IHLOC) with internal exercise locus of control (IEXLOC) for predicting the physical activity of college students (N = 84). Prospective observations of self-reported free-living physical activity (seven-day recall) and supervised running (time x distance) were made at 2-, 5-, and 9-week intervals. IHLOC predicted seven-day recall at Week 2 (beta = .19) and Week 5 (beta = .36) (increase in adjusted R2 ranged from .05 to .12, p less than .05). Consistent with theory, the prediction was not reproducible when generalized outcome-expectancy value rather than outcome-expectancy value for health was assessed. IHLOC was unrelated to supervised running. IEXLOC was unrelated to activity in all analyses, even though exercise-specific measures of outcome-expectancy values (beta s = .20) and perceived barriers (beta s = .27-.32) predicted both seven-day recall and supervised running (p less than .05). IHLOC also discriminated (p less than .05) high active and low active subjects when criterion groups were formed from population norms on seven-day recall (greater than or less than 280 kcal.kg-1.week-1). Results indicate that tests of decision theories that include locus of control measures specific to health or exercise must adjust for fitness, perceived barriers to physical activity, and behaviorally relevant outcome-expectancy values of physical activity when studying college students. The construct validity of exercise locus of control remains uncertain for college students.

Adult↗
PubMed1989

[The Research Institute for Molecular Pathology (I.M.P.)--a new approach for cancer development].

The aim of basic research at the I.M.P. is a more comprehensive understanding of cancer development that should lead to less aggressive and more efficient therapies in future. Molecular biological methods provide a valuable tool to describe the genetic defects and malfunctions of the cancer cell, an understanding of which is essential for the establishment of causal cancer treatment. Several working groups are studying aspects of cellular growth and its regulation from different points of view. One group is investigating yeast genetics, because there the network of genetic interactions can be followed up most easily. In mouse genetics the question of how the so-called proto-oncogenes act during embryonic development is being looked at. Model systems indicate how oncogenes reprogram the cells, and how growth signals enter the nucleus to induce new cascades of gene activity. By characterizing transcriptional and post-transcriptional factors it might well be possible to forge an approach towards the growth signals in the cytoplasm. During these investigations the results will be continuously scrutinized for useful therapeutic concepts.

Academies and Institutes↗
PubMed1989

[Gas exchange in swine before, during and after motor activity of different intensity and length].

4 female and 2 male untrained fattening pigs, weighing 43.9 +/- 1.6 kg at the beginning of the experiment underwent continuous measurement of VO2, VCO2, and rectal temperature, prior to, during, and after running on a horizontal exercise belt set to speeds of 0.7, 1.3, and 2.5 m.s-1. The highest values of VO2 and VCO2 (ml-min-1/kg-1) and rectal temperature (degrees C) were usually measured few minutes after running. They were 18.84 +/- 3.65 and 20.4 +/- 4.53 as well as 41.2 +/- 0.4, 28.41 +/- 4.07 and 33.26 +/- 5.92 or 41.3 +/- 0.5, 26.21 +/- 7.7 and 32.32 +/- 7.14 as well as 40.5 +/- 0.7, depending on the above belt speeds. Exercise belt speeds of 1.3 to 1.8 m.s-1 were found to be suitable for testing aerobic metabolic capacity of untrained young pigs.

Animals↗
PubMed1989

[Gas exchange in boars of different development stages during motor activity].

Continuous measurements were performed on 16 untrained boars for VO2, VCO2, and rectal temperature, prior to, during, and after running exercises on an horizontal exercise belt, with speeds set to 1.3 m.s-1 corresponding to something between 23 and 43 kg of body weight b.wt. or 0.7 and 1.3 m.s-1 corresponding to 76 to 86 kg of b.wt. The highest values of VO2 and VCO2 (ml.min-1/kg-1 b.wt.) and of rectal temperature (degrees C) were 36.78 +/- 3.57, 40.23 +/- 6.17, and 41.9 +/- 0.6 in younger animals or 21.49 +/- 2.46, 22.53 +/- 3.12, 40.8 +/- 0.5, 29.3 +/- 5.15, 30.6 +/- 4.77, and 40.7 +/- 0.45 for somewhat older animals for belt speeds of 0.7 and 1.3 m.s-1. Exercise belt speeds of 0.7 to 1.3 m.s-1 were found to be suitable for testing aerobic metabolic capacity of untrained young boars.

Animals↗
PubMed1989

[Gas metabolism and body temperature during submaximal, maximal and supramaximal physical activity of swine].

VO2, VCO2, gas exchange ratio (R = VO2/VCO2), and rectal body temperature were continuously measured on 6 young fattening pigs and 16 boars during repeated runs (0.7, 1.3, and 2.5 m/s-1) on a horizontally moving belt. Close correlations, almost linear, were found to exist between VO2, VCO2, and rectal temperature in situations in which VO2 moved close to its individual maximum as a result of preselected challenge intensity. None of these 3 parameters was increased further and in keeping with turnover, if higher challenge intensities were chosen.

Animals↗
PubMed1989

[The oxygen uptake capacity of swine].

Comprehensive studies into domestic pigs and wild boars together with literature data provided a basis for an assessment of aerobic metabolic capacity (VO2max) of swine. The values quoted, from 20 to 94 ml/min-1/kg, had been due to several factors of methodological approach, growth, training, and nutrition as well as to pathophysiological aspects. For full capacity utilisation of VO2max, untrained pigs can be challenged at belt velocities between 0.8 and 1.8 m/s-1 and trained animals at 5 m/s-1.

Animals↗
PubMed1988

Reliability and concurrent validity for a 7-d re-call of physical activity in college students.

We conducted four studies to examine the reliability and validity of a 7-d re-call for estimating free-living physical activity in college students. High and reproducible correlations (r's = 0.82 to 0.87) between the re-call and a concurrent 7-d diary were observed, and re-call effectively classified subjects into highly active (greater than or equal to 280 kcal.kg-1.wk-1) and inactive (less than 245 kcal.kg-1.wk-1) groups. Significant correlations between re-call and a psychometric predictor of physical activity (self-motivation) were also robust across samples and consistent with those seen when direct measures of activity have been used. Increases in time and distance records for supervised running were accompanied by increases in total and vigorous re-call, but not in moderate re-call, supporting the re-call's sensitivity to measured changes in group activity levels. Re-call was not, however, highly correlated with supervised running, and this is consistent with its use as a measure of free-living activity. Re-call was also not spuriously contaminated by response distortion or attitudinal variables, and intra-class reliability for repeated assessments of total (PI = 0.89) and vigorous (PI = 0.90) re-call was high across 7 wk. Finally, re-call provided a better estimate of a 7-d diary than did practical bio-behavioral estimates of habitual activity (12-min run and skinfold thickness), and re-call was highly correlated with a concurrent physical activity questionnaire (r's = 0.83 to 0.94) and VO2max (ml.kg-1.min-1) (r = 0.61). Our results are consistent with previous studies on community-based adult populations; they support that the 7-d re-call is reliable and valid for college students when compared with concurrent bio-behavioral and self-report estimates of physical activity.

Adolescent↗
PubMed1988

Lipoma and liposarcoma of the parotid gland: high-resolution preoperative imaging diagnosis.

Over the past 7 years, nine fatty tumors within the parotid gland have been managed (eight lipomas, one liposarcoma). High-resolution computed tomography examination was carried out in all cases; with correct preoperative diagnosis recorded each time. The computed tomography imaging characteristics of lipoma, liposarcoma, and the differential diagnosis from other fat density lesions, such as a fatty infiltration, appear quite specific. The liposarcoma and six of the lipomas were resected at formal parotidectomy with facial nerve preservation. Two patients with small intraglandular lipomas have elected to undergo long-term clinical and imaging observation. Our experience indicates that high-resolution, soft-tissue imaging with computed tomography and magnetic resonance imaging permits consistent preoperative fatty tumor diagnosis. This imaging input facilitates rational treatment decision-making.

Absorptiometry, Photon↗