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M Stek

Publications and source records attributed to M Stek.

28 records · Page 2Linked to original sources
PubMed1981

Attrition of schistosomes in an irradiation-attenuated cercarial immunization model of Schistosoma mansoni.

The attrition of Schistosoma mansoni challenge worms was studied in irradiation-attenuated cercaria-immunized mice as a function of site and time. The peak recovery of schistosomula from the lungs of immunized mice was delayed 2 days in comparison with non-immunized controls. The difference between the peak recoveries of control and immunized mice accounted for about half of the final attrition observed at the 7-week adult worm stge. Hepatic-mesenteric vein worm recoveries obtained 10 to 42 days after challenge were reduced in most cases at least as much as the 49-day counts. Somewhat higher reductions were observed at 14 to 28 days than at 49 days, confirming the evidence of delayed migration obtained at the lung phase. These findings, coupled with histologic observations, indicate that at least half of the worm elimination attributable to immunization occurs 8 or more days after the challenge infection.

Animals↗
PubMed1980

Malaria chemoprophylaxis.

Travelers to areas where malaria is endemic must be apprised of the risks they will face and the methods they should employ to prevent infection. Patients should be screened for glucose-6-phosphate dehydrogenase deficiency, and a chemoprophylactic drug should be prescribed. Chloroquine should be given to tourists traveling to areas where chloroquine resistance has not been reported. For travelers to chloroquine-resistant areas, sulfadoxine with pyrimethaime or some other synergistic drug combination should be prescribed.

Anopheles↗
PubMedDate not supplied

Erythroadsorption and enzyme-linked immunoassays (EAIA and ELISA) for specific circulating antibodies and antigens in schistosomiasis.

We developed a method of immunologic titration by erythroadsorption in order to assay anti-Schistosoma mansoni soluble cercarial antigen IgM antibodies and anti-S. mansoni soluble worm and egg antigen IgG antibodies. This method was compared to the ELISA technique. Results obtained using the two techniques were similar, although the erythroadsorption technique was less sensitive for identifying IgM during the acute phase of the disease. Both assay systems revealed a correlation between the level of circulating soluble antigens contained in the eggs and the number of eggs found in the stools of this particular group of patients.

Animals↗