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Biomedical subjects

M Stopiński

Publications and source records attributed to M Stopiński.

5 recordsLinked to original sources

[Nephrotoxicity of aminoglycosides. III. Preventive studies with subcutaneous administration of converting enzyme inhibitor, captopril].

The effect was studied of the converting enzyme inhibitor (captopril) on the gentamicin nephrotoxicity in rats. Captopril 25 mg/kg b.w. and gentamicin 100 mg/kg b.w. were injected subcutaneously in a single daily dose. Three groups of Wistar male rats were studied: 1) treated with gentamicin 3 and 7 days, 2) treated with gentamicin and captopril, 3) treated with captopril. The mean serum creatinine and urea levels and proteinuria in the second group were significantly higher than in the first one. Light and electron microscopy examinations demonstrated increased renal cortex damage in the second group. There were not differences between mean urea and creatinine levels in the third examined group and normal rats. Mechanism of gentamicin nephrotoxicity enhancement in the second group is unknown.

Animals

Dehydrogenase activity in the bottom sediments of three lakes.

Dehydrogenase activity was studied in the sediments of three lakes of the Iława Lakeland (Jeziorak, Mały Jeziorak and Jasne) with reference to the type of lake, the season of the year, the situation of the sediments, pH and temperature. The highest activity was found in the sediments of the eutrophic lake Jeziorak sampled during the summer from places in the vicinity of a village. The lowest activity was exhibited by sediments sampled in the autumn in the lakes Jasne and Mały Jeziorak. No correlation was found between dehydrogenase activity and the number of bacteria in the sediments. The highest dehydrogenase activity was found at 20 degrees and pH 7.0 and 8.0--8.25.

Bacteria

Studies on metabolic activity of planktonic bacteria isolated from three lakes.

Studies were carried out on metabolic activity of 480 bacterial isolates on 9 substrates. All bacterial isolates studied except one utilized the casamino acids. Also with casamino acids the highest oxygen uptake values were obtained. Among the carbohydrates, glucose was most frequently utilized by the planktonic bacteria. Bacteria isolated from water of the various lakes differed in their metabolic activity as well as in the capability of utilizing the individual substrates. The capability of attacking by the bacteria the substrates applied depended largely upon the time of their isolation.

Amino Acids

[Ultrasonic examination of the parathyroid glands, bone x-ray and calcium deposits of the eye in diagnosis of secondary hyperparathyroidism in light of 12 observed cases].

Twelve patients with chronic renal failure treated with repeated dialysis underwent subtotal parathyroidectomy. Histologic examination revealed hyperplasia parathyroidal adenoma in all patients. Diagnostic correlation between bone X-ray, ultrasound of parathyroid glands, calcium deposits in cornea and conjunctiva, and histological findings has been analysed. Radiological abnormalities have been noted in 8 patients (66%), parathyroid glands hyperplasia in 9 (75%), and corneal and conjunctival calcium deposits in 10 (83%) patients. These data confirm the value of techniques under study for the diagnosis of the secondary hyperparathyroidism in patients with chronic renal failure.

Adult