Biomedical subjects

M Stosović

Publications and source records attributed to M Stosović.

7 recordsLinked to original sources

PubMed1996

[Radiographic changes in the sella turcica in female patients on chronic hemodialysis].

The bone disease in chronic renal failure patients with secondary hyperparathyroidism is usually termed renal osteodystrophy. Radiographic methods have been applied in renal bone disease mainly to discover lesions on long bones, hands and fee. During the evaluation of hormonal disturbances of hemodialysed chronic renal failure female patients, roentgenograms of sella turcica were taken. Findings that were detected were most probably the consequences of renal osteodystrophy. Osteoporosis of clinoid processes posteriores and dorsum sellae and intrasellar calcifications were confirmed in 25 percent of investigated patients. Lateral view of the sellae turcica demonstrated a "double floor".These pathological findings in sella turcica region could be of practical importance because of well known anatomophysiological position of this sceletal structure.

Adult↗

PubMed1996

[Hemostatic system parameters in patients with chronic renal insufficiency and arteriovenous fistula thrombosis].

Functional disturbances among different tissues and organic systems are associated with chronic renal failure. The most common problems following the disturbances in complex hemostatic changes in uremic patients are prolonged bleeding time ant the increased thrombosis tendency. As the patients vascular access is critical to the treatment of the chronic haemodialysis patient, we performed an investigation of causes of repeated vascular access thrombosis with purpose of detecting any consistent abnormality of the haemostatic system. Research has been conducted on a group of 29 patients (14 males and 15 females), age 21 to 61 (x = 45), on regular haemodialysis from 1 to 6 years (x = 2.2); 23 of them having one episode of thrombosis of vascular access, and 6 having two episodes. Partial thromboplastin time was among the normal ranges in all investigated subjects, three of them had low prothrombine time and thrombine time was prolonged in two cases. The high fibrinogen value was found in 19 patients. Mean value of platelet count was normal, though seven patients had thrombocytopenia. Absence of coagulum retraction was found in three patients. Assessment of blood coagulation in this study could not explain the development of repeated thrombotic events affecting arterio-vein fistula in chronic renal failure patients receiving haemodialysis. That points out the necessity to analyze functional status of natural coagulation inhibitors, fibrinolytic system and platelet function.

Adult↗

PubMed1996

[Monitoring the nutritional status in patients on hemodialysis].

In order to monitor changes of the nutritive status of hemodialyzed patients, antropometric and laboratory parameters of the population of hemodialyzed patients in 1988 vs. 1994 have been compared. Antropometric parameters were measured by the same investigator. The results show absence of significant difference between antropometric parameters (body weight after hemodialysis, body mass index, triceps fold, circumference of upper arm and percentage of fat) in the patients hemodialyzed in 1988. The laboratory parameters (albumin and transferrin), however, show significant increase in the 1994 group. In the group of patients subjected to hemodialysis in 1988 as well, albumin was significantly elevated. Nevertheless, no differences in laboratory parameters in healthy populations of 1988 and 1994 were noted (controls). It was concluded that no significant changes in the nutritive status were present among either the population or the same patients, while elevation of laboratory parameters necessitate further investigation.

Anthropometry↗

PubMed1996

[Analysis of data on hemodialyzed patients for the development of a data base].

Needs for state-of-the-art records on haemodialyzed patients implies abandoning of conventional paper work and development of a computer data base on haemodialyzed patients. Thus, data on haemodialyzed patients were analyzed. Since haemodialysis is a specific mode of treatment and differs from out-patient and in-patient management, the records also differ from conventional files and histories. The analysis has shown that the data can be groupedinto two sets: dialysis list and history of a haemodialyzed patient. The list contains the data at the onset of dialysis, and the end of the process, and in hourly intervals. The history contains mainly relatively permanent data (personal data and basal medical parameters), annual (records and primary data) and monthly (dialysis records, history and current condition, laboratory analyses and therapy). Most of the data are systematic, i.e. periodic and necessitate tabular presentation. It has been concluded that due to the tabular presentation and predominance of systematic information, the data base will be superior to conventional records.

Humans↗

PubMed1994

Treatment of secondary hyperparathyroidism with intermittent oral high doses of 1-alpha-OHD3 plus pharmacological dose of 24,25(OH)2D3.

The present study examined the effect of intermittent oral high doses of 1-alpha-OHD3 in combination with a pharmacological dose of 24,25(OH)2D3 on parathyroid hormone (PTH) secretion. Twenty hemodialysis (HD) patients (10 males, aged 26-72 years, on regular hemodialysis for 7-128 months) with secondary hyperparathyroidism resistant to long-term low-dose 1-alpha-OHD3 therapy were studied for 24 weeks. At the outset of the study they were randomly divided into two groups: group 1 received high-dose 1-alpha-OHD3 plus 24,25(OH)2D3 (2 x 5 micrograms/day) and group 2 was on monotherapy with 1-alpha-OHD3. 1-alpha-OHD3 was given three times a week in the evening before each HD in gradually increased doses from 1 to 4 micrograms adjusted to keep serum calcium levels below 2.6 mmol/L. During the therapy mean serum calcium and ionized calcium levels increased but remained in the normal ranges without differences between the two groups. However, the frequency of hypercalcemia episodes was different in the two groups. In the first 12 weeks the number of hypercalcemia episodes was significantly lower in group 1 than in group 2 (6 vs. 12; p < .05), allowing the use of significantly higher 1-alpha-OHD3 doses in group 1. In the second 12 weeks of the study the 1-alpha-OHD3 dose in group 1 had to be reduced due to more frequent appearance of hypercalcemia. So, the 1-alpha-OHD3 doses became similar in the two groups during the second 12 weeks of the study.(ABSTRACT TRUNCATED AT 250 WORDS)

24,25-Dihydroxyvitamin D 3↗

PubMedDate not supplied

[Quantitative approach to dialysis adequacy (part two)].

A quantitative assessment of dialysis and prescription of dialysis as therapy in every single patient have always been a continuous problem. Numerous efforts have been made to date to determine the kind of therapy for patients on hemodialysis on the basis of simple objective indices instead of clinical and laboratory parameters. Some of these indices have been widely accepted nowadays. Although the main clinical and laboratory parameters have still been currently applied in the assessment of peritoneal dialysis adequacy, serious quantitative approaches are made even in these cases regarding the more accurate therapy. The first part of the article deals with the development of quantitative approach to dialysis adequacy in certain models; the second part concerns dialysis prescription based on Gotch's and Sargent's modification of the American National Cooperative Dialysis Study (NCDS) as well as on Direct dialysis quantification (DDQ) and peritoneal dialysis adequacy.

Humans↗

PubMedDate not supplied

[Tables of composition of prepared foods for patients on hemodialysis].

Numerous mutually contradictory conditions in diets for haemodialysis patients require knowledge about the composition of prepared food for each individual patient. The aim of this study was to make appropriate tables of prepared food on the basis of the analysis of patients nutrition. A list of the food way of its preparation was formed after dietary interviews. The most frequent food was prepared in the usual way and its composition was computed with food tables. The tables of prepared food composition facilitate the prescription of dietary daily meals, and make the therapy easier.

Diet↗