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Biomedical subjects

M Strauch

Publications and source records attributed to M Strauch.

At least 19 recordsLinked to original sources
PubMed1992

Washing erythrocytes to remove interferents in measurements of zinc protoporphyrin by front-face hematofluorometry.

Zinc protoporphyrin (ZPP) is determined by hematofluorometry of whole blood to detect iron deficiency in blood donors. In hospitalized patients, ZPP did not correlate with established markers of iron status. We performed 4500 ZPP measurements with the Aviv front-face hematofluorometer in samples from 475 patients and measured ferritin, transferrin saturation, hemoglobin, and erythrocyte indices. We found that the fluorometric determination is affected by substances dissolved in plasma but that this interference can be eliminated by using washed erythrocytes. In validation tests the within-day variation was < 3.5%; the day-to-day variation was < 6.8%. In 130 healthy persons without iron deficiency, ZPP was < or = 40 mumol/mol heme, which we consider a normal value. Mean ZPP in 46 iron-deficient patients was 256 (SD 105) mumol/mol heme (correlation with ferritin: -0.73; with hemoglobin: -0.85; P < 0.001). When washed erythrocytes are used, the hematofluorometric determination of ZPP is sensitive and specific for detecting iron deficiency in otherwise healthy individuals and hospitalized patients.

Blood Donors↗
PubMed1977

[Complications and lethality after kidney grafts (author's transl)].

Similarly good survival rates were obtained in 113 patients with kidneys transplanted from deceased persons as with patients on home dialysis. The retrospective study showed that fatal complications were not predominantly caused by septic diseases running fateful courses under immunosuppression, but by risk factors which were not recognized soon enough or were incorrectly treated. In our opinion, with careful preparation and supervision of these patients, even in the still unsatisfactory state of immunosuppressive therapy, the possibility exists of carrying out renal grafting without increased risk of mortality compared with dialysis treatment.

Adolescent↗
PubMed1977

Clotting in dialyzers due to low pH of dialysis fluid.

During November and December 1975 frequent clotting occurred in the extracorporeal circuits of different dialyzers used in our unit. After installation of new automatically regenerating ion exchange resin columns,, the pH of deionized water ranged from 4.2 to 8.4 during 24 hr periods. Dialysate pH ranged between 5.3 and 8.2, and the patient's whole blood pHs ranged from 7.15 to 7.4 at the dialyzer inlet and from 6.2 (!) to 7.4 at the outlet. A strong correlation was seen between the acidity of the water and the frequency of clotting, and it was considered possible that the clotting was due to structural changes within the heparin molecules induced by the low pH. Following the introduction of an automatic titration device into our dialyzate preparation system, clotting with consecutive blood loss and subjective clinical symptoms have disappeared.

Humans↗
PubMed1975

[Gastric mucosal dysplasias: what is their clinical significance (author's transl)].

Using criteria of proliferation kinetics, karyometry, histology and histochemistry, the attempt at a definition of normal and dysplastic surface epithelium of the gastric mucosa is made. Instead of using such terms as surface carcinoma, intra-epithelial carcinoma and carcinoma-in-situ, the term dysplasia III of the surface epithelium is suggested, because serial biopsies of gastric mucosa over periods ranging from one month to two years have demonstrated reversibility or persistence of such changes without transition into early carcinoma. Results of such studies in 8 262 patients demonstrate that even proliferation-kinetic, karyometric and histochemical methods do not make it possible to judge from single tests the prospective potency of certain changes of the gastric surface mucosa as "precancerous" or even "intra-epithelial carcinoma".

Carcinoma in Situ↗