Biomedical subjects

M Suero

Publications and source records attributed to M Suero.

5 recordsLinked to original sources

PubMed2006

Facial skin fluorescence as a marker of the skin's response to chronic environmental insults and its dependence on age.

BACKGROUND: Throughout life facial skin is exposed to a variety of adverse environmental conditions and is constantly required to repair itself. The rate of epidermal cell proliferation is indicative of the skin's repair rate and can be monitored noninvasively in vivo using skin intrinsic fluorescence markers. OBJECTIVES: The goal of the present study was to assess the effects of ageing, geographical region, ethnic origin and season on the ability of facial skin to repair itself in the presence of chronic environmental insults using in vivo fluorescence spectroscopy. METHODS: Skin fluorescence emission was measured on the cheeks of 522 individuals in winter and repeated in summer in five different geographical locations in the Asia-Pacific region. Fluorescence emission was also measured from 80 caucasians of fair complexion in the United States (New Jersey area) on the face and on a relatively protected area (upper inner arm). The age range of the participants was 14-75 years. RESULTS: We found that epidermal proliferation rates decrease monotonically with age, while the fluorescence of collagen and elastin cross-links increases with age indicating accumulation of advanced glycation end-products. These trends were independent of geographical region, ethnic origin and season of measurement. Epidermal proliferation rates of facial skin were higher than those of unexposed sites; they may be 10 times higher in younger (second decade) than in older (seventh decade) individuals, and they decrease with age at rates 10 times faster compared with those of unexposed sites. CONCLUSIONS: This is the first time that epidermal proliferation and its dependence on ageing have been measured noninvasively on the human face. The higher tryptophan fluorescence values on the face vs. the protected site are indicative of accelerated rates of epidermal proliferation in the presence of chronic environmental insults. The repair potential of facial skin, i.e. its ability to maintain high proliferation rates, is maximal in younger populations and gradually decreases with age.

Adolescent↗

PubMed2001

Study status consistency and duplicate-read protection in a distributed architecture.

UNLABELLED: This presentation will discuss the benefits and pitfalls of implementing a study status and duplicate-read protection mechanism within a distributed picture archiving and communication system (PACS) architecture. There are many advantages to a distributed PACS network in which image studies are proactively pushed to reading stations before they are required by a radiologist. The absence of a central server, which serves on demand, makes managing study status and protecting against duplicate reads challenging. The system to manage study status and read access must be efficient, robust, and easy to administer. A system is presented that accomplishes these goals while maintaining the advantages of a distributed architecture. METHODS: The basic workflow of the system is that image studies acquired at a modality device are automatically sent to an archive server. Using a set of advanced routing rules, the archive automatically routes studies to diagnostic workstations where studies are candidates for diagnostic read. The workstations display a list of all local studies available for reading. A monitor application running on the workstations coordinates access to studies for diagnostic read. Once the status of a study has been changed, the workstations on the networks and the archive are notified, which causes the study to be automatically removed from any list on a workstation where it might be a read candidate. RESULTS: Implementation of this system provides a balanced workflow throughout the system while minimizing the need for costly high-speed network hardware. Additionally studies are read as soon as they are available by the next available radiologist. This workflow is enabled without the need for specific interaction by any of the radiologists on the network. By having the images available at the workstation in an organized worklist, this methodology increases the efficiency of the radiologist. CONCLUSION: The implementation of this system enables a radiology department, or even a specialty group within a department, to gain the benefit of a distributed system as well as the benefits provided by a central-server architecture. This can be done very cost effectively with minimal configuration overhead and hardware requirements.

Computer Systems↗

PubMed2001

A model of the formation of illusory conjunctions in the time domain.

The authors present a model to account for the miscombination of features when stimuli are presented using the rapid serial visual presentation (RSVP) technique (illusory conjunctions in the time domain). It explains the distributions of responses through a mixture of trial outcomes. In some trials, attention is successfully focused on the target, whereas in others, the responses are based on partial information. Two experiments are presented that manipulated the mean processing time of the target-defining dimension and of the to-be-reported dimension, respectively. As predicted, the average origin of the responses is delayed when lengthening the target-defining dimension, whereas it is earlier when lengthening the to-be-reported dimension; in the first case the number of correct responses is dramatically reduced, whereas in the second it does not change. The results, a review of other research, and simulations carried out with a formal version of the model are all in close accordance with the predictions.

Humans↗

PubMed2001

Characterization of publication rotogravure press emission rates and compositions.

Emission compositions and rates were determined during production for a publication rotogravure press room at a large rotogravure printing company. The press room housed a single 4-color, 8-print-stand press, with an 84" paper web. Average press speed was 1800 feet per minute. Data were collected over a 2-day period and included measurements of ventilation, room area concentrations, duct exhaust compositions, amount and composition of inks used, and worker exposures. These data were used with mass balance models that were appropriate for the workspace. Toluene comprised more than 90 percent of the inks and solvents and accounted for more than 90 percent of the press emissions. Average toluene emissions during press operation and press off conditions were 222 kg/hr and 8-38 kg/hr, respectively. The uncontrolled toluene emission on the basis of printed paper throughput was 3 g/m2. Of the total toluene released, 90 percent was captured by the local exhaust ventilation. The measured control efficiency was much lower than the average efficiency of 97 percent for the month of the test reported by the plant. A mass balance model evaluation demonstrated that only the lower efficiency was consistent with measured room concentrations. Using the measured emission rates and actual monthly press on and press off conditions, the difference in efficiency for the plant (10 rotogravure presses) extrapolates to the additional release to the workspace and ambient environment of over 700 tons/yr of toluene.

Air Pollution, Indoor↗

PubMed1991

Motion of complex patterns is computed from the perceived motions of their components.

A plaid pattern made by adding two gratings of the same spatial frequency, one moving 45 deg above the horizontal, and the other moving 45 deg below the horizontal, appears to move horizontally when the speeds of the two components are equal. If the apparent speed of the upward-moving component is reduced by a motion after-effect (MAE), the plaid appears to move obliquely downwards, unless the actual speed of the downward-moving component is reduced to match the (reduced) apparent speed of the upward moving component. This is consistent with the hypothesis that the visual system computes the motion of a plaid pattern in two stages, first estimating the motions of the components, and then combining them according to the intersection of constraints. An alternative explanation: that the vertical component of the plaid's motion is caused by an MAE in a horizontally oriented distortion product generated by non-linear transduction or transmission of the plaid, is ruled out by the finding that the adapting stimulus causes only a very weak vertical MAE.

Adaptation, Ocular↗