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Biomedical subjects

M Sugamata

Publications and source records attributed to M Sugamata.

28 records · Page 2Linked to original sources

Dependence on the birth season of the antibody level against West Nile virus in the Pakistani population.

Variation of antibody level against West Nile (WN) virus depending on the season of birth was followed among 151 paired serum samples of healthy Pakistani persons in Karachi, collected twice in July and October, 1985. The persons born during the months between February and June had lower positive antibody rate and lower responsiveness in haemagglutination inhibition and neutralizing tests against WN virus than those born during the other months. This phenomenon implies that the ability to produce antibodies against WN virus among Pakistani persons may depend on their birth season.

Adolescent↗

Dependence on the birth season of the level of haemagglutination inhibition antibodies against Japanese encephalitis virus in the Japanese population.

According to the frequency of haemagglutination inhibition (HI) antibodies against Japanese encephalitis (JE) virus the Japanese population born during the years of JE epidemic falls into 2 groups. The population born during the epidemic season of JE (from July to October) showed a lower rate of HI antibody positivity to JE virus than those born during the non-epidemic season (from November to June). This phenomenon was not related to the birth place of investigated subjects and was not related to JE vaccination.

Antibodies, Viral↗

Evidence for the possible function of the fluorescent granular perithelial cells in brain as scavengers of high-molecular-weight waste products.

The fluorescent granular perithelium (FGP) of rats and humans under experimental and pathological conditions was examined with the electron microscope. The FGP incorporated high molecular-weight protein (ferritin) and carbon particles administered intraventricularly. In a case of spontaneous cerebral hemorrhage, the FGP was found to contain lipoidal products and minute fragmented cell debris. The FGP in a patient with lipidosis contained pale inclusion bodies. In aged individuals, the inclusion bodies formed irregular larger aggregates.

Aging↗

Japanese encephalitis virus infection in fetal mice at different stages of pregnancy I. Stillbirth.

The relationship between the stage of pregnancy at the time of Japanese encephalitis (JE) virus inoculation and the frequency of stillbirth was investigated in mice. Pregnant mice inoculated at nine to sixteen days before parturition demonstrated a higher frequency of stillbirth (38%, 12/32) than mice similarly inoculated at one to eight (20%, 6/30) or at seventeen to twenty (14%, 2/14) days respectively before parturition. Stillbirth frequency in the control group was 1.4% (1/72). Five out of thirteen stillborn of mothers inoculated at nine to sixteen days before parturition were positive in virus isolation tests, and three others showed congenital malformations, anencephaly, encephalocele and underdevelopment below the waist.

Animals↗

Japanese encephalitis virus infection in fetal mice at different stages of pregnancy. II. Resistance to Japanese encephalitis virus infection.

The relationship between the stage of pregnancy of mice at the time of Japanese encephalitis (JE) virus inoculation and the resistance of JE virus infection of their offsprings was investigated. It was found that there was a stronger resistance to JE virus infection in offsprings born of mothers inoculated with JE virus at nine to sixteen days before parturition than in offsprings of mothers inoculated at one to eight days or at seventeen to twenty days before parturition. Resistance of the offsprings to JE virus infection lasted up to the age of 180 days after birth.

Animals↗

The relative toxicity of metal salts to immune hemolysis in a mixture of antibody-secreting spleen cells, sheep red blood cells and complement.

The relative toxicity of metal salts was examined using a mixture of antibody-secreting spleen cells, sheep red blood cells and complement. The amount of immune hemolysis in the mixture was reduced by mercuric chloride, methylmercuric chloride and nickel chloride at concentrations of 14 microM or more, by sodium selenite and zinc chloride at 140 microM or more, and by sodium selenate, cadmium chloride, cadmium acetate, chromic chloride and beryllium chloride at 1400 microM. On the other hand, the amount of immune hemolysis was increased by both cadmium chloride anc cadmium acetate at concentrations of 14 and 140 microM. Mercuric chloride, methylmercuric chloride and nickel chloride were assumed to inhibit the antibody secretion of antibody-forming spleen cells.

Animals↗