Glycogen accumulation in axons of canine sympathetic ganglion.
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Biomedical subjects
Publications and source records attributed to M Sugimura.
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In our recent studies on aging phenomena in animals, polyglucosan bodies (PGB) were found within the smooth muscle in the digestive tract of aged dogs without neurologic signs. PGB were basophilic, round, or oval bodies which appeared to have a homogeneous or concentric shape. Their histochemical properties were characterized by the presence of glucose polymers (polyglucosan). Electron microscopy revealed that PGB were composed mainly of irregularly clustered, short branching filaments measuring about 90 A in width. PGB were histochemically and ultrastructurally identical to the previously reported Lafora-like bodies in the CNS of aged dogs. PGB were found in all aged dogs and were disseminated throughout the digestive tract, especially in the cecum.
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The migration of macrophages in chick bone marrow was studied by histoplanimetry after an intravenous injection of colloidal carbon or iron-dextran. In the initial stages after the injection, carbon-laden macrophages were found only in the sinus, where erythrocytopoiesis took place. The carbon-laden macrophages then passed through the sinus wall and gradually migrated from the sinus to the extravascular area (i.e., the granulocytopoietic region) peaking at 1 to 3 days after injection. After 7 days, almost all the carbon-laden macrophages accumulated to form "macrophage islets" mainly around the lymphatic nodules in the extravascular area. In the cases injected with iron-dextran, the movement of iron-laden macrophages was similar to that of the carbon-laden ones. The similarity suggests that the direction and time of migration of macrophages are independent of ingested materials.
A case of cementifying fibroma growing into the right maxillary sinus is reported. Clinical and histopathological findings are presented. The differentiation from central fibro-osseous lesions in jaw bones is discussed.
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The duck spleen was examined histoplanimetrically after neonatal surgical thymectomy, cyclophosphamide treatment, and/or X-ray irradiation. The development of the periarterial lymphoid tissues, which consisted mainly of small lymphocytes, was inhibited in the spleen of the Tx and Tx-X ducks. The peri-ellipsoidal lymphoid tissues, consisting of pyroninophilic medium or large sized lymphocytes, was greatly depleted in the Bx and/or CY ducks. The germinal centres also showed probable bursa dependency. On the other hand, the development of the perivenous lymphoid tissue was not inhibited after Tx and Bx. A number of plasma cells was distributed in the red pulp of the Bx and/or CY duck spleen.
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