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M Sulc

Publications and source records attributed to M Sulc.

32 records · Page 2Linked to original sources
PubMed1986

[Gerstmann-Sträussler-Scheinker disease].

In three of six observations of familial dementia in adult age neuropathological examination revealed Gerstmann-Sträussler-Scheinker's disease characterized from the morphological aspect by amyloid plaques and a spongious state of the gray matter of the brain. As to the latter characterization the disease is close to Jacob-Creutzfeld's disease. The presence of amyloid plaques signalizes extreme production of protein material which cumulates. It is obviously different from amyloid of senile plaques in Alzheimer's disease and corresponds probably to infectious protein material-prions.

Adult↗
PubMed1984

The metabolic fate of [14C]oxaprotiline.HCl in man. I. Disposition and preliminary pharmacokinetics.

Absorption, biotransformation and elimination of [14C]oxaprotiline.HCl have been studied after oral administration of 50 mg doses to two human subjects. Absorption was complete, and peak blood concn. of total 14C were 590 and 297 ng equiv./ml after 3-6 h in the two subjects. After 11 days, 84 and 90% dose was excreted in urine, and a total of 98% was excreted. Peak blood concn. of unchanged oxaprotiline were 16 and 19 ng/ml before, and 167 and 207 ng/ml after enzymic hydrolysis. The blood half-life in the two subjects was 23 and 29 h. The blood concn. of the desmethyl metabolite was low (2 ng equiv./ml), but also increased after hydrolysis (11-19 ng equiv./ml). Oxaprotiline was bound (83%) in vitro to serum proteins. Sixty per cent was bound to serum albumin and 20% to alpha 1-acid glycoprotein. In urine only 1% of total 14C was present as unchanged oxaprotiline, and 0.2% as the desmethyl metabolite. After enzymic hydrolysis these increased to 48 and 6%, respectively, and after acid hydrolysis to 85 and 10%.

Administration, Oral↗