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Biomedical subjects

M Svjetlicić

Publications and source records attributed to M Svjetlicić.

7 recordsLinked to original sources
PubMed1997

Persistence of humoral immunity to rabies 1100 days after immunization and effect of a single booster dose of rabies vaccine.

Forty-four vaccinees immunized with rabies vaccine and human rabies immunoglobulin according to the abbreviated intramuscular regimen (the 2-1-1 schedule) were followed-up after 1100 days and had their blood samples taken. The persistence of rabies neutralizing antibody was proven in the sera of all vaccinees. 56% of whom demonstrated titres > or = 0.5 IU ml-1. At the same day the vaccinees were given a single booster dose of vaccine whose effect was measured 2 weeks later. With the RFFI test on day 1114, sera revealed an extraordinarily high booster response in all 44 vaccinees. The study proved the anamnestic response after a full course of rabies vaccination to be a very stable one, and the capability of a single booster dose of vaccine to evoke high-titred rabies antibody response. Of the four vaccines used in the study, under comparable conditions HDCV proved superior to PCECV PDEV and PVRV on all 3 days of serology-35, 1100 and 1114, though this difference was statistically attested only on days 35 and 1114.

Adult↗
PubMed1993

Preventive medicine in Croatia through time and space.

The Croatian preventive medicine was well-known in the world through history. It was famous from the time of the quarantine in Dubrovnik, through sanitary cordon and contribution in obligatory first immunization against smallpox. Croatia presented Andrija Stampar as the leader in preventive medicine from the World War I till the sixties. We owe him all kinds of public health work both in organization and education as well as the initiating the World Health Organization. Knowledge and capabilities of Croatian preventive medicine workers were demonstrated the most clearly during the Croatian homeland war in 1991/91 when the infectious diseases as permanent war companions did not have effect on the state of health of the people in Croatia.

Communicable Disease Control↗
PubMed1988

Interaction of rabies vaccine with human rabies immunoglobulin and reliability of a 2-1-1 schedule application for postexposure treatment.

Five commercially available rabies vaccines (HDCV, FBKC vaccine, PCEC vaccine, PVRV and PDEV) applied alone or combined with human rabies immunoglobulin (HRIG) were administered, by random allocation, to 161 volunteer vaccinees, using the abbreviated 2-1-1 postexposure immunization schedule. Protective levels of rabies antibody were demonstrated in all vaccinees by day 14, and in all but one vaccinee from day 21 to day 90. Partial inhibition of the antibody response due to HRIG was observed for three vaccines (PCEC vaccine, PVRV and PDEV). In terms of economy, reliability and rapid antibody induction, the 2-1-1 schedule proves superior to the presently recommended regimen for postexposure rabies prophylaxis.

Adult↗
PubMed1986

An evaluation of second generation tissue culture rabies vaccines for use in man: a four-vaccine comparative immunogenicity study using a pre-exposure vaccination schedule and an abbreviated 2-1-1 postexposure schedule.

In a double-blind comparative trial the immunogenicity of three new tissue culture rabies vaccines was evaluated, using a commercial human diploid cell vaccine (HDCV) lot as the reference. Two different vaccination regimens, a pre-exposure schedule, and an abbreviated 2-1-1 postexposure schedule (two doses of the vaccine applied bilaterally on day 0, with subsequent single doses given on days 7 and 21) were employed. In both, two of the new vaccines, purified chick embryo cell vaccine and purified Vero rabies vaccine, induced an antibody response equivalent to that of HDCV, while the geometric mean titres for the fetal bovine kidney cell vaccine were somewhat lower. The 2-1-1 regimen, a candidate regimen for economical rabies postexposure treatment, evoked a rapid and high titre antibody response with all four vaccines, peaking on day 14.

Adult↗