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Biomedical subjects

M Swerdlow

Publications and source records attributed to M Swerdlow.

At least 19 recordsLinked to original sources
PubMed1992

"Chronicity," "nervios" and community care: a case study of Puerto Rican psychiatric patients in New York City.

The role of ethnicity, community structure, and folk concepts of mental illness in facilitating the adaptation of long term psychiatric patients to community living has received little attention. This article examines the cultural concepts of mental illness and the community involvement of 30 Puerto Rican psychiatric patients participating in a New York City treatment program. It is shown that many of the attributes usually associated with chronic mental illness do not apply to this population. It is argued that the folk concept of nervios helps to foster the integration of these patients in a wide range of community networks. The impact of gentrification on these patients' community integration is also discussed.

Adaptation, Psychological↗
PubMed1988

Subacute osteoporotic compression fracture: misleading magnetic resonance appearance.

Three patients with benign subacute osteoporotic vertebral compression fractures are presented. T1 weighted magnetic resonance (MR) images (SE 500/30) showed decreased vertebral signal. Because the results of the MR examination were thought to indicate malignant disease, extensive medical workups, including one biopsy, were pursued in all three patients. Routine (SE 500/30) spin-echo pulse sequences cannot definitively distinguish between benign and malignant vertebral compression fractures.

Aged↗
PubMed1981

Anticonvulsant drugs used in the treatment of lancinating pain. A comparison.

The value of anticonvulsant drugs in the treatment of some cases of lancinating pain is now established. The results in 170 consecutive cases in an ongoing series are reported with special reference to the efficacy of four anticonvulsants--carbamazepine, clonazepam, phenytoin and valproate. The findings are discussed.

Adolescent↗
PubMed1981

A light and electron microscopic study of liver and lung tumors induced by a single low dose of diethylnitrosamine (DEN) in C57BLXC3H F1 mice.

The effect of a single intragastric dose of DEN was studied in 15-day-old male C57BLXC3H F1 mice. Group 1 was given 0.315, group 2, 0.625 micrograms/g, and group 3 served as a vehicle control. Animals were sacrificed at regular intervals up to 75 weeks. Liver and lung tissue were examined by light and electron microscopy. Mice of group 1 and 2 developed liver lesions ranging from hyperplastic nodules to hepatocellular adenomas and carcinomas. The incidence of these lesions varied with the length of observation period. Electron-dense crystalline inclusions of alpha 1 antitrypsin were found in the dilated cisternae of the rough endoplasmic reticulum of the hyperplastic and adenomatous nodules. The incidence of lung adenomas was significantly higher in group 3 than groups 1 and 2; ultrastructurally these tumors contained both Clara cells and type II pneumocytes. The results indicate that DEN is effective even in a low single dose in inducing liver and lung tumors in mice.

Animals↗
PubMed1980

Alpha-1-antitrypsin in intracellular inclusions of diethylnitrosamine induced hepatomas of C57BLxC3H F1 mice.

Six large hepatic nodules obtained 46 to 74 weeks after a single dose of diethylnitrosamine (0.625 or 1.25 micrograms/gm) in infant C57BLxC3H F1 male mice were studied to elucidate the nature of intracytoplasmic inclusions in the hepatic cells of these nodules. By light microscopy, the nodules constituted a spectrum of lesions ranging from some which were well differentiated adenomas to others which were frank carcinomas. Round or oval eosinophilic intracytoplasmic inclusions were consistently seen in the well differentiated adenomatous lesions. Some of these inclusions were PAS positive and resisted diastase digestion while others were either negative or only weakly PAS positive. By electron microscopy, they were most commonly crystalline, contained a reticulated electron dense material and were located in the distended rough endoplasmic reticulum. On immunofluorescence the inclusions showed marked specific reactivity with antisera against human alpha-1-antitrypsin. The presence of alpha-1-antitrypsin in these inclusions was further supported by the resistance of these inclusions to digestion by trypsin or papain but not by the pepsin or pronase.

Animals↗
PubMed1980

The treatment of "shooting" pain.

Anticonvulsant drugs were given to 70 patients suffering from lancinating pains of various clinical aetiologies. Serum drug estimations were used to ensure that an effective dose level was achieved. In about 66% of the cases, treatment produced some diminution in the intensity and/or frequency of the "flashes" of pain. The neurophysiological and pharmacological rationales are briefly explained. It is concluded that this use of anticonvulsant agents merits further study.

Adolescent↗
PubMed1980

[Pain relief therapy for cancer pain (author's transl)].

A brief account is first given of the incidence and characteristics of cancer pain. The management of such pain should involve treatment of the malignant condition, psychological support, pharmacological supplementation and interruption of the pain pathways. The paper proceeds to detail the various methods by which this last objective can be achieved. The most widely applicable method is intrathecal injection of a neurolytic agent-phenol, chlorocresol or alcohol. This will provide 2-4 months relief in about 60 per cent patients. More prolonged and extensive relief can be done by cordotomy; the percutaneous procedure has the advantages of involving no general anaesthesia and only brief hospitalisation. For patients with hormone dependent tumours and those with widespread pain, relief can be obtained by destruction of the pituitary gland with absolute alcohol. The injection is carried out through a needle inserted into the gland via the nose and sphenoid sinus; one or two repeat injections may be necessary. When pain is partly due to involvement of autonomic nerves, it is necessary to carry out appropriate autonomic neurolysis, e.g. coeliac plexus block for visceral pain. Finally, the paper deals with non-invasive pain relief techniques, especially dorsal column and central nerve stimulation.

Humans↗
PubMed1978

The role of the anaesthetist in chronic pain management.

The role of the anaesthetist in the continuing care of patients suffering from chronic pain has been discussed. Many of the techniques, both invasive and non-invasive, which are currently available for the treatment of chronic pain have been reviewed.

Anesthesiology↗
PubMed1978

Intrathecal neurolysis.

The present status of intrathecal neurolysis with phenol, alcohol, chlorocresol and saline in the management of chronic pain has been discussed and the results of treatment reviewed. The particular use of these techniques in the therapy of pain due to malignant conditions has been stressed.

Ethanol↗
PubMed1978

The value of clinics for the relief of chronic pain.

This paper is another of the papers presented at a conference on Pain organised under the auspices of the London Medical Group. Mark Swerdlow deals with the work of pain relief clinics and explores their value. He gives the background as to what these clinics are, describes who is treated, how they are staffed and finally offers his opinion as to their effectiveness.

Health Facilities↗
PubMed1977

[The role of the anesthetist in the treatment of chronic pain conditions (author's transl)].

There are many causes of chronic pain. A clinic for the treatment of chronic pain conditions must therefore be based on the team work of various special disciplines. The anesthetist who is interested in this field may be a very useful member of such a therapeutic team. Chemical blockade of nerves, transcutaneous stimulation of nerves, chordotomy, all belong to his special field. The results of treatment also depend, however, on the personality of the patient and the nature of the disease.

Anesthesiology↗