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Biomedical subjects

M Swiontoniowski

Publications and source records attributed to M Swiontoniowski.

5 recordsLinked to original sources

Stroke in young adults. A continuing diagnostic challenge.

Cerebrovascular disease in persons between 15 and 45 years of age is on the rise and represents a diagnostic challenge. With a thorough investigation, the cause of cerebral ischemic infarction or nontraumatic intracerebral hemorrhage can be identified in most cases and appropriate treatment can be administered. Subarachnoid hemorrhage is usually caused by ruptured saccular aneurysm, but misdiagnosis continues to be a problem. Angiography performed early in the course of illness is a safe diagnostic procedure in young adults with any type of cerebrovascular disease. Overall prognosis for young adults with cerebrovascular disease varies with the underlying disorder but is generally good.

Adolescent

Stroke recurrence within 2 years after ischemic infarction.

We prospectively studied stroke recurrence in 1,273 patients with ischemic stroke who were entered into the Stroke Data Bank. Median follow-up was 13 months. The 2-year cumulative recurrence rate among these patients was 14.1%. Age, sex, race, history of hypertension, atrial fibrillation, or transient ischemic attacks, and stroke location were not associated with a higher risk of stroke recurrence. Patients with an elevated blood pressure, an abnormal initial computed tomogram, or a history of diabetes mellitus were at a higher risk of stroke recurrence. In contrast, patients with an infarct of unknown cause were at a lower risk of stroke recurrence than patients with a defined stroke mechanism, such as lacune, embolism, or atherosclerosis. A multivariate model suggests that patients at the lowest risk for stroke recurrence have a low diastolic blood pressure, no history of stroke, no history of diabetes mellitus, and an infarct of unknown cause.

Cerebral Infarction

Transient global amnesia.

Transient global amnesia is often attributed to a seizure, vascular cause, or migraine, but the outcome is usually benign. The presence of migraine and important risk factors for stroke necessitates close patient monitoring. Anti-platelet therapy should be considered.

Amnesia

Cerebellar infarction--clinical and cranial computerized tomography correlations.

We analyzed the clinical and cranial computerized tomographic (CT) features of 10 patients with cerebellar infarction. Among patients with recent cerebellar infarction, the initial CT often failed to demonstrate any recognizable abnormality. Because early neurological deterioration may arise despite normal CT studies, a high level of clinical awareness is critical for appropriate intervention.

Adult