Elemental composition of human aorta in Marfan syndrome.
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Biomedical subjects
Publications and source records attributed to M Sych.
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The results of the investigations on the effect of highly concentrated normobaric oxygen on rabbit lung are reported. Detailed pathomorphological analysis demonstrated that rapidly developing extensive changes of the structural elements of the capillaries and other vessels were the prevalent lesions. These changes are connected, in the light of earlier experiments carried out under identical conditions, with the observed disturbances in the metabolism of pulmonary lipids and suggest pathogenetic correlations between prostaglandins and pulmonary surfactant.
In five volunteers the sensitivity of the respiratory centre to carbon dioxide after naloxone and nalorphine injections was studied using "double blind" method and increments of doses. Alterations in the respiratory centre sensitivity were reflected by changes in respiratory minute volume, which was measured before and after drug injections, as well as after carbon dioxide stimulation. Comparison of results and their statistical verification showed that nalorphine alone causes respiratory depression and carbon dioxide stimulation is, beside the weak initial action, almost ineffective. Naloxone causes very small, if at all, respiratory depression and the respiratory centre answers efficiently to carbon dioxide stimulation.
The authors worked out and applied a new device of positive pressure valve encased in the rebreathing circuit and one-way Ruben's valve, as well as a modification of Rees's system making it possible to conduct excess gases containing anaesthetics outside the operating theatre. These devices and modifications are completely reliable owing to their simplicity and their construction is cheap. They effectively reduce the degree of atmospheric pollution in the operating theatre with anaesthetics used in inhalation anaesthesia. They may be applied to every type of apparatus used for general anaesthesia.