Biomedical subjects

M Szogyi

Publications and source records attributed to M Szogyi.

2 recordsLinked to original sources

PubMed2003

Molecular interactions between DPPC and morphine derivatives: a DSC and EPR study.

The interaction between different morphine derivatives (morphine, codeine, N-methyl-morphine, N-methyl-codeine) and alpha-L-dipalmitoyl phosphatidylcholine (DPPC) liposomes was studied with differential scanning calorimetry (DSC) and electron paramagnetic resonance (EPR) spectroscopy. Small unilamellar DPPC-liposomes with the given morphine-derivative were prepared by sonication. The size distribution of liposomes was checked by dynamic light scattering (DLS). The amount of entrapped morphine was determined spectrophotometrically. Our results indicate that the morphine and its derivatives principally interact with the lipid head groups, and this interaction leads to a decrease in the mobility of the polar head groups, especially in case of codeine and N-methyl-codeine.

1,2-Dipalmitoylphosphatidylcholine↗

PubMed1991

Hydrophobic interaction between tryptophan and some synthetic nucleosides.

The interaction of 29 synthetic nucleosides with tryptophan was studied by charge-transfer reversed-phase thin-layer chromatography and the relative strength of interaction was calculated. In the majority of cases Trp significantly decreased the lipophilicity of the nucleosides. This effect may be due to the interaction between the more hydrophilic Trp and the more lipophilic nucleosides, resulting in charge-transfer complexes of moderate lipophilicity. Stepwise regression analysis proved that the length of the alkyl substituent of nucleosides significantly influences the strength of interaction. Our findings supports the hypothesis that the nucleosides turn toward Trp with their alkyl substituent and the binding is of hydrophobic character.

Chromatography, Thin Layer↗