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Biomedical subjects

M T Antonini

Publications and source records attributed to M T Antonini.

6 recordsLinked to original sources
PubMed1987

[The value of respiratory function tests in the surveillance of asthmatic children].

The purpose of pulmonary function testing in children with asthma is to search for obstructive airway disease. We examined the charts of 169 asthmatic children during intervals between acute exacerbations. The severity of asthma was determined according to VIALATTE classification, with the Tiffeneau ration FEV1/VC (1) and the MMFR/VC ratio serving as obstructive indices. According to these data, children were classified into three groups: normal children (normal FEV1/VC and MMFR/VC), children with probable obstruction of the distal airways (normal FEV1/VC and decreased MMFR/VC), and children with both proximal and distal airway obstruction (decreased FEV1/VC and MMFR/VC). Since suggested normal values vary in the literature, we compared FEV1 and MMFR to determine as accurately as possible the number of children with obstructive disease. The relationship between the degree of clinical involvement and pulmonary function testing results was studied. Clinically, asymptomatic children with suspected normal respiratory function had evidence of obstructive disease in two out of three cases, and would benefit from drug therapy.

Adolescent↗
PubMed1976

[Stability and variation of the maximal ventilation and maximal expiratory volume ratios].

The level of stability of the ratio (alpha coefficient) of maximal ventilation (MBC) over maximal expiratory volume per second (FEV1) was continued statistically for its practical value in estimating the respiratory functional incapacity. Three observations were made: --the mean value of the alpha coefficient=MBC/FEV1 is independent of the sex, age, size or weight in the normal subject; alpha was slightly higher than that found from theoretical values of MBC (CECA) and FEV1 (BALDWIN and COURNAND); --the alpha coefficient varied with the vital capacity (VC) and with FEV1; --there was a particularly simple relation between alpha and VC: alpha decreased from 38 to 30 when VC increased from 1 to 6 litres.

Age Factors↗
PubMedDate not supplied

[Blood lactate in the steeplechase horse: triangular and rectangular series of steps during short duration races].

Five steeplechase race horses were observed during incremental and constant-load exercises with the aim of separating effects of work rate and time on blood lactate. Each independent exercise (an incremental and three constant load tests) was a sequence of three two-minute runs, separated by two one-minute rest intervals for jugular blood sampling. The following observations were made: 1. During constant load exercises, in the five horses, blood lactate stabilized below 4 mmol.l-1: lactatemia critical velocity (LVC) = 3.33 +/- 0.16 mmol.l-1. Nevertheless, VCL, critical lactate velocity inducing LVC, was not statistically different from VS4, velocity inducing a 4 mmol.l-1 blood lactate during incremental tests. Remaining reticent on the meaning of "lactate threshold" often attributed to VS4, an incremental exercise thus seemed pertinent for routine long-term surveys of endurance. 2. If delta L is the blood lactate increase within a single short run, delta L increases linearly with running velocity for an incremental test, allowing the calculation of a "null" velocity, the highest velocity for which there is no significant lactate increase. For independent runs, delta L increased exponentially with velocity, with noticeable differences between horses. This individual short-term functional adaptation variability could be considered in assessment and follow-up of race horse fitness.

Animals↗
PubMedDate not supplied

Comparison between late onset and childhood asthma.

BACKGROUND: The onset of asthma frequently occurs after the age of 50 yr and the severity and causes of this late onset disease are poorly known. METHODS: 25 chronic asthmatics (65.7 +/- 6.5 yr) whose asthma started after the age of 50 yr were compared with 23 chronic asthmatic children (11.6 +/- 2.8 yr) and 24 COPD patients (61.6 +/- 3.4 yr). Both asthmatic groups had a similar apparent duration of asthma. None of the asthmatics was a smoker. All COPD were smokers. The severity of asthma was defined according to the Aas score. FVC, FEV1, MMEFR, Raw were tested and reversibility of bronchial obstruction was determined on Raw after salbutamol inhalation. Allergy was assessed by skin prick tests, RAST and total serum IgE (PRIST). RESULTS: Patients with childhood asthma had: 1) a significantly lower clinical severity of asthma; 2) a significantly less severe bronchial obstruction, and 3) a significantly greater reversibility than old age asthmatics. There was no significant difference between pulmonary function tests pre- and post-bronchodilators between COPD and old-age asthmatics. All asthmatic children and 40% of older patients were allergic. CONCLUSIONS: The occurrence of asthma in old age patients leads to a more severe course of the disease and allergy appears to play a role in many old age patients.

Adolescent↗