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Biomedical subjects

M T Barrellier

Publications and source records attributed to M T Barrellier.

25 records · Page 2Linked to original sources

The Kurloff cell. Its differentiation in the blood and lymphatic system.

Kurloff cells belong to the group of macrophages as far as ultrastructure, adhesiveness and identification with Kupffer cells (in the case of the liver) are concerned. A characteristic group of features makes it easy to recognize them: PAS reaction, cyanol-blue staining, presence of myelin figures in electron microscopy and attachment to glass-slides. Kurloff cells are thymic and blood cells. They are observed in small numbers in the circulating blood and, in large quantities, in spleen (red pulp), liver (hepatic sinusoids) and lung (septal capillaries). They are absent from lymphatic nodules and from diffuse lymphatic tissues. Morphological and experimental studies indicate that, in spite of some equivocal similarities, Kurloff cells are distinguishable by many criteria from erythrophagocytic cells and from protein-secreting blood cells.

Animals↗

[Lymphedema: is there a treatment?].

More than hundred medical treatments for lymphedema have been described. This very high number shows the evidence of difficulties: lymphatics are very small vessels, under low pression and velocity respondent to spontaneous quiet lymphatic contractions. The treatments can be listed in 3 groups: 1) physiotherapeutic methods, increasing lymphatic flow: cold, field stimulation, manual lymph drainage, intermittent compression, heat; 2) drugs: venous agents (flavone, benzo-pyrone), and intraarterial lymphocytes injection, promoting lymphatic flow or increasing normal proteolysis by macrophages in order to remove trapped proteins from interstitial fluid; 3) surgical procedures subdivided in 2 groups: excisional techniques and bridging drainage techniques; radical or partial excision removes involved subcutaneous tissue, recently by the way of liposuction; Efforts to drain lymphedema by subcutaneous implants, pedical flaps, myocutaneous flaps, omental transposition and intestinal flaps are historical. Microsurgical lymphatic anastomosis to vein (nodo-venous then lymphovenous), and to lymphatic themselves are now performed: lymphatic collectors or venous autografts are interpositioned to by-pass lymphatic blockade with end-to end anastomosis. The free transplantation of a lymphatic flap with its own vascularisation from healthy inguinal nodes to axillary blockade is the last described procedure. Lymphatic anastomosis are not needed. Actually, physiotherapy is always first indicated. Benzo-pyrones are additive drugs. Excisional procedures concern monstruous lymphedema. Microsurgical bridging procedures can be attempted only for secondary lymphedemas. They could be of benefit if physiotherapy and elastic bandages, stockings or sleeves, could then be avoided. Studies assessing independently the efficiency of each procedure are needed.

Anastomosis, Surgical↗

[Venous ultrasonography of the lower limbs in the diagnosis of thrombosis. Examination methodology and presentation of results].

Two criticisms are levelled against venous ultrasonography: its operator-dependent nature and the absence of any overall imaging document which can serve as a reference and be read by all. A very precise investigation technique is suggested to deal with the first criticism. This describes the investigation in detail, level by level from the inferior vena cava to the lower third of the leg and indicates the optimal position of patient and operator, in particular concerning the leg. A method of imaging presentation is proposed to deal with the second criticism. The site and extent of venous thromboses are shown on a precise anatomical diagram including muscle veins. This diagram reproduced by reduction on a four-fold card is given to the patient to be used during subsequent follow-up. It can be used as a reference document in case of suspected extension or recurrence. Ultrasonography has several advantages over phlebography: a better reliability rate, better sensitivity for lesions in muscles and where there are twin veins, possibilities of differential diagnosis of DVT and of the discovery of concomitant pathology. It should now always be performed as the investigation of primary intention.

Evaluation Studies as Topic↗

[Buerger's disease. Clinical and therapeutic review. Apropos of a case].

In reference to a typical case of Buerger's disease, the clinical, arteriographic, histological signs as well as diagnostic criteria are restated. The pathogenesis is still unknown; a genetic predisposition and an auto-immune process could be involved. The treatment, presently symptomatic, cannot arrest the evolution which is often mutilating, when the patient continues to smoke. An early diagnosis is possible in the presence of superficial phlebitis or Raynaud's phenomenon.

Adult↗

[Evaluation of the results of a sclerosing treatment. Concordance between 2 examiners].

With the aim of determining criteria by which results of a sclerosant treatment could be assessed in a multicentric study, 35 sapheno-femoral junctions (26 long saphenous veins and 9 short saphenous veins) treated by sclerotherapy beforehand, were controlled separately and confidentially by two examiners, first clinically, then using the Doppler. The concordance rates were analysed for each of the tests carried out: fascial palpation, clinical and ultrasound percussive permeability, clinical and ultrasound search for reflux, measurement of length of reflux. The results confirm the superiority of the Doppler technique, both in the diagnosis of ostial permeability and reflux (concordance superior at 90% as opposed to 68 to 80% for the clinical tests), and in the quantification of the reflux (strong positive correlation, r = 0.83, between the values given by the two examiners). The doppler technique provides an excellent concordance of differentiated clinical sensibility between the examiners. The permeability, by Doppler, and the length of the audible reflux are proposed as criteria for assessment of the result of a sclerosant treatment, during the follow-up.

Adult↗

[Superficial venous thromboses of the legs].

The study concerned 106 superficial venous thrombosis (SVT) diagnosed thanks to an echo-Doppler, between october 1989 and february 1993 in 42 men and 63 women aged 59 +/- 18 years and 64 +/- 18 years respectively. In nearly half cases, clinical sign was a suspicion of a deep venous thrombosis (DVT) (34 cases) or a pulmonary embolism (PE) (14 cases). A supposed precipitating factor was found in 65 cases out of 105: a cancer already known in 11 cases. The SVT was located in the left lower limb in 56 cases, in the right lower limb in 41 cases and a bilateral one in 9 cases. The long saphenous vein was affected in 60 cases, the short saphenous vein in 22 cases, both saphenous veins in 6 cases and a non-collateral saphenous vein in 17 cases. In 38 cases, a DVT added to a SVT, either separately in 19 cases, 9 of which in controlateral or by proximity extension from an arch in 7 cases or from a more distal perforating vein in 8 cases. In total, complications, either DVT or SVT, appeared in 46 cases out of 105. The age of > or = 60 has been associated with the presence of complications. In 3 cases, a cancer was discovered in the month following the SVT. These results question the benignancy of SVT. They match those of two series of SVT diagnosed thanks to echo-Doppler and recently reported. They urge to explore systematically both venous networks, superficial and deep and to achieve an etiologic balance either for SVT or unexplained DVT.

Adult↗