PubMed Health⌕ Search

Biomedical subjects

M T Kovalchik

Publications and source records attributed to M T Kovalchik.

9 recordsLinked to original sources
PubMed1982

Prescribing medication in long-term dialysis units.

Little information is available regarding the current patterns of medication use in long-term dialysis centers. Therefore, we surveyed the medication records of 1,023 patients undergoing long-term dialysis therapy in 27 dialysis centers. The mean number of medications prescribed per patient was 7.7 +/- 0.54, increasing patient age, increasing duration of dialysis, in-center dialysis, and the presence of underlying diabetic and hypertensive nephropathy were associated with increased frequency of medication use. The use of multiple pharmacologic agents was associated with a high frequency of drug duplication (12%), potential dosage error (9%), potential significant drug interaction (15%), and use of contraindicated drugs (2.5%). A lack of individualization of the use of several pharmacologic agents was apparent. An extreme degree of center variability in drug use was also apparent. Periodic review of medication use should be undertaken in the long-term dialysis setting.

Adult↗
PubMed1978

The kidney in progressive systemic sclerosis: a prospective study.

Nine normotensive progressive systemic sclerosis patients with normal renal function underwent renal biopsy. Four specimens had prominent vascular abnormalities, two mild vascular abnormalities, and three were normal. Vascular deposits of C3 were present in all specimens. Plasma renin activity was elevated in three of four patients with prominent vascular abnormalities, one of two patients with mild vascular lesions, and none of two patients with normal biopsies. Plasma renin activity elevation in response to cold pressor testing in the four patients with prominent vascular lesions was 5.6 ng/ml.h compared to 0.55 ng/ml.h in those with mild or no lesions and 0.26 ng/ml.h in six control subjects. These data indicate that renal vascular lesions may be present in normotensive patients. Elevation or a substantial rise in plasma renin activity (1.8 ng/ml.h or greater) in response to cold pressor testing suggests preclinical renal involvement.

Adult↗
PubMed1972

Neisseria gonorrhoeae: colonial morphology of rectal isolates.

Four principal colony types of gonococci have been previously described, and it has been shown that primary isolates from the urethra and cervix are primarily of colony types 1 and 2. In the present work, gonococcal isolates from the rectum were also shown to be predominantly colony types 1 and 2. Visualization and typing of gonococcal colonies in primary rectal isolates were facilitated by the use of medium containing vancomycin, colistin, nystatin, and, in some cases, trimethoprim lactate. Control experiments showed that these agents sometimes caused minor alterations in colonial morphology; but with knowledge of these alterations satisfactory colonial typing could be made.

Colistin↗